Abstract: The present invention relates to quinolone carboxylic acid derivatives having useful antibacterial activities of formula (I): ##STR1## wherein, R.sub.1, R.sub.2, and R.sub.3, which may be the same or different, are each hydrogen or a halogen atom, or a lower alkyl group optionally substituted with an amino or a hydroxy group;R.sub.4 is hydrogen atom, a lower alkyl, benzyl, t-butoxycarbonyl or ethoxycarbonyl group;R.sub.5 is hydrogen, chlorine atom, methyl or an amino group;R.sub.6 is a lower alkyl group, or a cyclopropyl or a phenyl group optionally substituted with a halogen atom; andX is nitrogen atom, or a methyne group optionally substituted with a lower alkyl or a lower alkoxy group or a halogen atom, and pharmaceutically acceptable salts thereof, and processes for preparing these compounds. The present invention also relates to novel intermediates which are useful for preparing the quinolone compounds of the invention.

Abstract: The present invention relates to novel quinolone carboxylic acid derivatives having useful antibacterial activities of formula (I): ##STR1## wherein, R.sub.1, R.sub.2, and R.sub.3, which may be the same or different, are each hydrogen or a halogen atom, or a lower alkyl group optionally substituted with an amino or a hydroxy group;R.sub.4 is hydrogen atom, a lower alkyl, benzyl, t-butoxycarbonyl or ethoxycarbonyl group;R.sub.5 is hydrogen, chlorine atom, methyl or an amino group;R.sub.6 is a lower alkyl group, or a cyclopropyl or a phenyl group optionally substituted with a halogen atom; andX is a methyne group optionally substituted with a lower alkyl or a lower alkoxy group or a halogen atom, and pharmaceutically acceptable salts thereof, and processes for preparing these compounds. The present invention also relates to novel intermediates which are useful for preparing the quinolone compounds of the invention.

Abstract: The present invention relates to novel quinoline derivatives of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, X, Y and Z are defined as in the specification, and pharmaceutically acceptable acid addition salts thereof, and also to processes for preparing these compounds.The present invention also provides an antibacterial composition comprising a compound of formula (I) or its acid addition salt as an active ingredient and pharmaceutically acceptable excipient.The novel quinoline derivatives of the present invention have an excellent antibacterial activity against bacteria or bacteroides.

Abstract: An athletic shoe has two independent, inflatable chambers, one in the sole and one partially forming the shoe upper. The former chamber cushions impacts and displaces solid material from which the sole would otherwise comprise, and the second tightens the fit of the shoe on a wearer's foot. Each chamber has independent inflation and outlet valves. Resilient pilings distribute a wearer's weight over the sole, protecting the first chamber from deformation during activity. A pump is detachably mounted on the shoe tongue. The pump has a ring for attachment to a key ring as an alternative to being secured on the shoe tongue when not in use. A preferred inflation medium is helium.