Patents by Inventor Tae-Song Kim

Tae-Song Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240116005
    Abstract: The present invention relates to a method for preparing a 3D biological bilayer membrane structure in a physiological buffer solution and a 3D biological bilayer membrane structure using the same, and more particularly, to a method for preparing a 3D biological bilayer membrane structure that is tightly sealed even under physiological ionic conditions by applying pressure during electroformation to improve a membrane fusion function, and a 3D biological bilayer membrane structure using the same.
    Type: Application
    Filed: September 29, 2023
    Publication date: April 11, 2024
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Tae Song KIM, Dong Hyun KANG, Bong Kyu KIM
  • Patent number: 11944998
    Abstract: A method of fabricating a capacitive micromachined ultrasonic transducer (CMUT) according to one aspect of the present invention may include forming, on a semiconductor substrate, a first region implanted with impurity ions at a first average concentration and a second region implanted with no impurity ions or implanted with the impurity ions at a second average concentration lower than the first average concentration, forming an insulating layer by oxidizing the semiconductor substrate wherein the insulating layer includes a first oxide layer having a first thickness on at least a part of the first region and a second oxide layer having a second thickness smaller than the first thickness on at least a part of the second region, and forming a membrane layer on the insulating layer such that a gap is defined between the second oxide layer and the membrane layer.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: April 2, 2024
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Byung Chul Lee, Dong-Hyun Kang, Jin soo Park, Tae Song Kim
  • Publication number: 20230271179
    Abstract: The present invention relates to a method for manufacturing a three-dimensional structure based on a block copolymer. The method comprises the steps of injecting a block copolymer (BCP) solution into each micro-well formed on the substrate and drying it to form a block copolymer layer, and applying a buffer to the block copolymer layer to hydrate the micro-well in three dimensions Forming the structure, after the three-dimensional structure is formed, injecting and curing a hydrogel solution around the three-dimensional structure may include the step of enhancing stability. In particular, the process of hydration by applying a buffer to the micro-well is performed while an electric field is applied. By controlling the concentration of the block copolymer (BCP) and the amplitude and frequency of the electric field, a three-dimensional artificial cell membrane having a desired size and shape, such as a spherical or ciliary shape and high stability (100% survival for 50 days) is manufactured can do.
    Type: Application
    Filed: November 22, 2022
    Publication date: August 31, 2023
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Tae Song KIM, Dong Hyun KANG
  • Patent number: 11313828
    Abstract: The biosensor includes a substrate, an electrode pattern positioned on the substrate, a passivation layer which is formed with a plurality of holes spaced apart from each other, and a bead positioned at one or more holes among the plurality of holes, and to which an antibody is attached, the electrode pattern includes a first electrode pattern part and a second electrode pattern part spaced apart from the first electrode pattern part, which has a same height as a height of the first electrode pattern part, and forms an electric field with the first electrode pattern part.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: April 26, 2022
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Ji Yoon Kang, Kyeong-Sik Shin, Jae-hoon Ji, Kyoseon Hwang, Tae Song Kim
  • Patent number: 10844503
    Abstract: A method for preparing a tightly sealed 3D lipid structure and a tightly sealed 3D lipid structure prepared thereby is disclosed. The method allows for simpler and more convenient preparation of an artificial biomembrane structure on a substrate using a lipid material, by using a plurality of transparent microwells formed on the substrate, and observation inside the microwells. In addition, a spherical 3D artificial single bilayer structure may be sealed very tightly through a simple method of changing the frequency of an electric field applied vertically to the microwells having a lipid layer formed. Through this, a biomimetic 3D structure having the structural and/or functional characteristics of a cell membrane constituting a cell can be provided more effectively.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: November 24, 2020
    Assignee: Korea Institute of Science and Technology
    Inventors: Tae Song Kim, Dong-Hyun Kang
  • Publication number: 20200298275
    Abstract: A method of fabricating a capacitive micromachined ultrasonic transducer (CMUT) according to one aspect of the present invention may include forming, on a semiconductor substrate, a first region implanted with impurity ions at a first average concentration and a second region implanted with no impurity ions or implanted with the impurity ions at a second average concentration lower than the first average concentration, forming an insulating layer by oxidizing the semiconductor substrate wherein the insulating layer includes a first oxide layer having a first thickness on at least a part of the first region and a second oxide layer having a second thickness smaller than the first thickness on at least a part of the second region, and forming a membrane layer on the insulating layer such that a gap is defined between the second oxide layer and the membrane layer.
    Type: Application
    Filed: March 18, 2020
    Publication date: September 24, 2020
    Inventors: Byung Chul LEE, DONG-HYUN KANG, Jin soo PARK, Tae Song KIM
  • Publication number: 20200087807
    Abstract: A method for preparing a tightly sealed 3D lipid structure and a tightly sealed 3D lipid structure prepared thereby is disclosed. The method allows for simpler and more convenient preparation of an artificial biomembrane structure on a substrate using a lipid material, by using a plurality of transparent microwells formed on the substrate, and observation inside the microwells. In addition, a spherical 3D artificial single bilayer structure may be sealed very tightly through a simple method of changing the frequency of an electric field applied vertically to the microwells having a lipid layer formed. Through this, a biomimetic 3D structure having the structural and/or functional characteristics of a cell membrane constituting a cell can be provided more effectively.
    Type: Application
    Filed: March 29, 2019
    Publication date: March 19, 2020
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Tae Song KIM, Dong-Hyun KANG
  • Patent number: 10585105
    Abstract: The present invention relates to a method for diagnosing a disease using an analysis of oligomer of an abnormal aggregated protein includes: (1) preparing a body fluid sample including at least one of blood, blood plasma, blood serum, saliva, urine, tear, and mucus; (2) making a dilution of the body fluid sample; (3) using a biosensor to measure and detect an aggregated protein in the diluted body fluid sample; (4) analyzing a signal change of the biosensor caused by the dilution of the aggregated protein to determine a slope according to the dilution from the measurements; and (5) analyzing a proportion of the oligomer from the slope according to the dilution to make a diagnosis. The method uses a biosensor to measure the impedance and the protein concentration of blood and detects the slope according to the numerical value of the monomer and the oligomer to diagnose normal or abnormal protein aggregation or the associated diseases with more accuracy.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: March 10, 2020
    Assignee: Korea Institute of Science and Technology
    Inventors: Ji Yoon Kang, Kyeong Sik Shin, Jae Hoon Ji, Tae Song Kim, Young Soo Kim, Sang Yun Kim
  • Publication number: 20190064175
    Abstract: Disclosed area methods for fabricating three-dimensional artificial lipid biomembrane structure arrays with sufficient reaction area and high stability on a substrate in a simpler and easier manner. The methods use constituent lipids of real cell membranes and a plurality of microwells formed on a substrate. The methods can more effectively provide biomimetic three-dimensional lipid membrane structure arrays that possess structural and/or functional properties of cell membranes.
    Type: Application
    Filed: April 17, 2018
    Publication date: February 28, 2019
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Tae Song Kim, Rhokyun Kwak, Won Bae Han
  • Patent number: 10006920
    Abstract: The present disclosure relates to a diagnostic kit capable of accurately diagnosing diseases or disorders related with abnormal aggregation or misfolding of proteins, including disorders or diseases caused by aggregation of ?-amyloid such as Alzheimer's disease as well as disorders or diseases caused by aggregation of other proteins, based on concentration analysis of the aggregated proteins before and after dissociation.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: June 26, 2018
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Young Soo Kim, Dong Jin Kim, Hye Yun Kim, Soo Min Cho, Tae Song Kim, Hyunjin Kim, Sejin Lee, Kyoseon Hwang, Jee Hoon Roh, Jae-Young Koh
  • Publication number: 20180080946
    Abstract: The present invention relates to a method for diagnosing a disease using an analysis of oligomer of an abnormal aggregated protein includes: (1) preparing a body fluid sample including at least one of blood, blood plasma, blood serum, saliva, urine, tear, and mucus; (2) making a dilution of the body fluid sample; (3) using a biosensor to measure and detect an aggregated protein in the diluted body fluid sample; (4) analyzing a signal change of the biosensor caused by the dilution of the aggregated protein to determine a slope according to the dilution from the measurements; and (5) analyzing a proportion of the oligomer from the slope according to the dilution to make a diagnosis. The method uses a biosensor to measure the impedance and the protein concentration of blood and detects the slope according to the numerical value of the monomer and the oligomer to diagnose normal or abnormal protein aggregation or the associated diseases with more accuracy.
    Type: Application
    Filed: May 18, 2016
    Publication date: March 22, 2018
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Ji Yoon KANG, Kyeong Sik SHIN, Jae Hoon JI, Tae Song KIM, Young Soo KIM, Sang Yun KIM
  • Patent number: 9753027
    Abstract: The present disclosure relates to a cantilever sensor, and a biosensor having the same, wherein the cantilever sensor including a slit formed on a flat board and a cantilever formed by the slit, a first electrode formed on the cantilever, and a second electrode formed on the flat board countered to the first electrode about the slit, wherein the electrodes are formed on the cantilever sensor having the slit, whereby sensing can be conducted by an electric method, through which the sensor can be effectively miniaturized.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: September 5, 2017
    Assignee: Korea Institute of Science and Technology
    Inventors: Kyoseon Hwang, Tae Song Kim, Rhokyun Kwak, Won Woo Cho, Myung Sic Chae
  • Publication number: 20170131233
    Abstract: The biosensor includes a substrate, an electrode pattern positioned on the substrate, a passivation layer which is formed with a plurality of holes spaced apart from each other, and a bead positioned at one or more holes among the plurality of holes, and to which an antibody is attached, the electrode pattern includes a first electrode pattern part and a second electrode pattern part spaced apart from the first electrode pattern part, which has a same height as a height of the first electrode pattern part, and forms an electric field with the first electrode pattern part.
    Type: Application
    Filed: January 13, 2016
    Publication date: May 11, 2017
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Ji Yoon Kang, Kyeong-Sik Shin, Jae-hoon Ji, Kyoseon Hwang, Tae Song Kim
  • Publication number: 20160103139
    Abstract: The present disclosure relates to a diagnostic kit capable of accurately diagnosing diseases or disorders related with abnormal aggregation or misfolding of proteins, including disorders or diseases caused by aggregation of ?-amyloid such as Alzheimer's disease as well as disorders or diseases caused by aggregation of other proteins, based on concentration analysis of the aggregated proteins before and after dissociation.
    Type: Application
    Filed: April 25, 2014
    Publication date: April 14, 2016
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Young Soo KIM, Dong Jin KIM, Hye Yun KIM, Soo Min CHO, Tae Song KIM, Hyunjin KIM, Sejin LEE, Kyoseon HWANG, Jee Hoon ROH, Jae-Young KOH
  • Publication number: 20150253313
    Abstract: The present disclosure relates to a cantilever sensor, and a biosensor having the same, wherein the cantilever sensor including a slit formed on a flat board and a cantilever formed by the slit, a first electrode formed on the cantilever, and a second electrode formed on the flat board countered to the first electrode about the slit, wherein the electrodes are formed on the cantilever sensor having the slit, whereby sensing can be conducted by an electric method, through which the sensor can be effectively miniaturized.
    Type: Application
    Filed: December 18, 2014
    Publication date: September 10, 2015
    Inventors: Kyoseon HWANG, Tae Song KIM, Rhokyun KWAK, Won Woo CHO, Myung Sic CHAE
  • Patent number: 9045747
    Abstract: The present invention relates to an apparatus and a method for fabricating a microcapsule, more particularly to an apparatus and a method for fabricating a microcapsule, which enable to encapsulate uniform cell number in a microcapsule through cell distribution, improve cell viability in the microcapsule through fluid exchange, and ensure uniform microcapsule size. The apparatus for fabricating a microcapsule according to the present invention uses a plurality of microchannels which are spatially connected with one another and are designed such that fluid flows through them in a particular direction, and comprises a cell supply unit which supplies a fluid mixture of cells and a cell dropletizing material; and a droplet forming unit in which a dropletization inducing fluid supplied from one of the plurality of microchannels joins with the fluid mixture of the cells and the cell dropletizing material to form a droplet.
    Type: Grant
    Filed: May 21, 2008
    Date of Patent: June 2, 2015
    Assignee: Korea Institute of Science and Technology
    Inventors: Choong Kim, Ji Yoon Kang, Tae Song Kim
  • Patent number: 8559900
    Abstract: A portable device for data communication using a body as a conductor to transmit data to a receiver, the portable device includes a data receiving unit to receive data, a controller unit to control processing of data to be transmitted, a current limiting circuit to limit a current of a signal corresponding to the data to be transmitted to a predetermined value, and transmitting electrodes connected to the current limiting circuit and to contact the body to transmit the signal having the current of predetermined value to the receiver.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: October 15, 2013
    Assignee: Korea Institute of Science and Technology
    Inventors: Tae-Song Kim, Jong-Oh Park, Byung-Kyu Kim, Jin-Seok Kim, Han Cheung, Won-Woo Cho, Nan-Young Yoon, Young-Rok Kim
  • Patent number: 8160672
    Abstract: The present invention provides method and system for data communication in the human body and a sensor therefor. The method and system transmit information through the human body to a receiver located outside the human body using low current and voltage polarity, so that they cause no damage to the human body and achieve low power consumption and better receiving sensitivity. In addition, the sensor contains a CMOS image sensor on which all circuits are integrated without radio transmitter and antenna, so that it achieves a low-priced and small-sized capsule type endoscope.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: April 17, 2012
    Assignee: Korea Institute of Science and Technology
    Inventors: Tae-Song Kim, Jong-Oh Park, Byung-Kyu Kim, Jin-Seok Kim, Han Cheung, Won-Woo Cho, Nan-Young Yoon, Young-Rok Kim
  • Patent number: 8155586
    Abstract: A portable device for data communication using a body as a conductor to transmit data to a receiver, the portable device includes a data receiving unit to receive data, a controller unit to control processing of data to be transmitted, a current limiting circuit to limit a current of a signal corresponding to the data to be transmitted to a predetermined value, and transmitting electrodes connected to the current limiting circuit and to contact the body to transmit the signal having the current of predetermined value to the receiver.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: April 10, 2012
    Assignee: Korea Institute of Science and Technology
    Inventors: Tae-Song Kim, Jong-Oh Park, Byung-Kyu Kim, Jin-Seok Kim, Han Cheung, Won-Woo Cho, Nan-Young Yoon, Young-Rok Kim
  • Publication number: 20110286722
    Abstract: A portable device for data communication using a body as a conductor to transmit data to a receiver, the portable device includes a data receiving unit to receive data, a controller unit to control processing of data to be transmitted, a current limiting circuit to limit a current of a signal corresponding to the data to be transmitted to a predetermined value, and transmitting electrodes connected to the current limiting circuit and to contact the body to transmit the signal having the current of predetermined value to the receiver.
    Type: Application
    Filed: August 1, 2011
    Publication date: November 24, 2011
    Inventors: Tae-Song KIM, Jong-Oh PARK, Byung-Kyu KIM, Jin-Seok KIM, Han CHEUNG, Won-Woo CHO, Nan-Young YOON, Young-Rok KIM