Abstract: The present disclosure relates to an isolated anti-FcRN antibody, which is an antibody binding to FcRN (stands for neonatal Fc receptor, also called FcRP, FcRB or Brambell receptor) that is a receptor with a high affinity for IgG or a fragment thereof, a method of preparing thereof, a composition for treating autoimmune disease, which comprises the antibody, and a method of treating and diagnosing autoimmunre diseases using the antibody. The FcRn-specific antibody according to the present disclosure binds to FcRn non-competitively with IgG to reduce serum pathogenic auto-antibody levels, and thus can be used for the treatment of autoimmune diseases.

Abstract: Systematic Evolution of Ligand Exponential Enrichment (SELEX) is involved to screen DNA/RNA aptamers that recognize a target molecule (including biomolecules such as nucleic acids, lipids, sugars, proteins, and peptides, hormones, low molecular weight chemical substances, toxic substances, ions, etc.). In general, in order to perform SELEX, a process of fixing a target molecule on a substrate or bead surface is required. In addition, since positive/negative monitoring is not possible in each round of a SELEX process to observe whether an aptamer library is actually well combined with a target substance, whether the SELEX process is proceeded correctly is checked by analyzing aptamers screened through several rounds. In order to remarkably solve these conventional problems and to construct a simpler and easier SELEX technique, the present disclosure provides a new SELEX technique using gold nanoparticles.

Abstract: The present invention relates to a biothiol detecting composition comprising a redox regulation protein, a method for detecting biothiols by using the same, and a biosensor/kit for detecting biothiols. The present invention provides the effect of rapidly measuring free biothiols in body fluids. In addition, relative content ratios and changes of total to free biothiols in body fluids can be detected in real time, which allows biothiols to be available as main indices of diseases through which prediction and warning can be made against various diseases. Further, because various redox stress changes associated with main diseases can be accounted for by variations of biothiols, the present invention can provide important technical, economical, and social values for the investigation of pathogenesis mechanisms and the diagnosis of diseases in the future.

Abstract: The present invention relates to a novel mechanism for regulating GSK3 kinases, including BIN2 and human GSK3-beta, by dephosphorylating GSK3 kinases through the PP1 phosphatase, such as the plant BSU1 phosphatases and human PP1-gamma.