Patents by Inventor Taeyoung Koo

Taeyoung Koo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250002883
    Abstract: The present disclosure relates to a composition for gene editing and a use thereof. According to the present disclosure, an adenine base editor LbABE8e system in which a Cas12a protein variant including one or more mutations and adenine deaminase are fused has altered PAM specificity to achieve a significant genomic single base editing effect on target DNA, and thus expands the range of applicable CRISPR system selection. Accordingly, due to gene editing, it is expected that the adenine base editor LbABE8e system may be widely used in various fields, such as gene therapy, creation of commercial profits with industrial strains with improved productivity, improvement of the quality of public health care through improvement of intestinal microorganisms, and improvement of crops and livestock breeds free from GMO issues.
    Type: Application
    Filed: June 28, 2024
    Publication date: January 2, 2025
    Inventors: Taeyoung Koo, Dae Sik Kim, Eun Young Choi, Hye Yeon Hwang
  • Patent number: 9302014
    Abstract: The present invention discloses cell penetrating peptides (CPP or membrane translocating peptide) and their conjugates with cargo molecules. The peptides are useful as drug delivery systems, particularly as delivery vehicles for nucleotide-based therapeutics, such as polynucleotides, oligonucleotides and peptide nucleic acids. A CPPs of the invention provides a balance between good cell entry efficiency and low toxicity and comprises three contiguous domains: the central one being hydrophobic and the flanking ones consisting of arginine and aminohexanoic acid or beta-alanine residues. The hydrophobic domain contains a sequence selected from YQFLI, YRFLI, IQFLI and IRFLI.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: April 5, 2016
    Assignee: Medical Research Council
    Inventors: Michael John Gait, Andrey Alexandrovich Arzumanov, Amer F. Saleh, Matthew J. A. Wood, Corinne Betts, Taeyoung Koo
  • Publication number: 20140342992
    Abstract: The present invention discloses cell penetrating peptides (CPP or membrane translocating peptide) and their conjugates with cargo molecules. The peptides are useful as drug delivery systems, particularly as delivery vehicles for nucleotide-based theraputics, such as polynucleotides, oligonucleotides and peptide nucleic acids. A CPPs of the invention provides a balance between good cell entry efficency and low toxicity and comprises three contiguous domains: the central one being hydrophobic and the flanking ones consisting of arginine and aminohexanoic acid or beta-alanine residues. The hydrophobic domain contains a sequence selected from YQFLI, YRFLI, IQFLI and IRFLI.
    Type: Application
    Filed: August 29, 2012
    Publication date: November 20, 2014
    Applicant: Medical Research Council
    Inventors: Michael John Gait, Andrey Alexandrovich Arzumanov, Amer F. Saleh, Matthew J.A. Wood, Corinne Betts, Taeyoung Koo