Patents by Inventor Tafadzwa MLAMBO

Tafadzwa MLAMBO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Micro RNA expression constructs and uses thereof
    Patent number: 11649455
    Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: May 16, 2023
    Assignees: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICH
    Inventors: Karl-Heinz Krause, Francis Rousset, Patrick Salmon, Marco Alessandrini, Roberto Speck, Simon Bredl, Tafadzwa Mlambo, Renier Myburgh
  • Micro RNA expression constructs and uses thereof
    Patent number: 11613747
    Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: March 28, 2023
    Assignees: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICH
    Inventors: Karl-Heinz Krause, Francis Rousset, Patrick Salmon, Marco Alessandrini, Roberto Speck, Simon Bredl, Tafadzwa Mlambo, Renier Myburgh
  • Construct for epigenetic modification and its use in the silencing of genes
    Patent number: 11072782
    Abstract: Herein described is a construct for epigenomic modification of genes composed of: (a) a Krüppel-associated box zinc finger protein or homologous, (b) a DNA region capable of binding to the target gene or homologous, (c) a human DNA methyltransferase DNMT3A or homologous and (d) a murine DNA methyltransferase Dnmt3L or homologous, wherein components a), b), c) and d) are linked to each other either directly or via at least one linker. The construct is a designer epigenome modifier that can be used to silence genes coding for a protein in leukocytes that avoids the internalization of HI viruses in immune cells.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: July 27, 2021
    Assignee: Albert-Ludwigs-Universitaet Freiburg
    Inventors: Toni Cathomen, Claudio Mussolino, Tatjana I. Cornu, Tafadzwa Mlambo, Sandra Nitsch, Jamal Alzubi, Marianna Romito
  • MICRO RNA EXPRESSION CONSTRUCTS AND USES THEREOF
    Publication number: 20210095278
    Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.
    Type: Application
    Filed: April 1, 2019
    Publication date: April 1, 2021
    Applicants: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICH
    Inventors: Karl-Heinz KRAUSE, Francis ROUSSET, Patrick SALMON, Marco ALESSANDRINI, Roberto SPECK, Simon BREDL, Tafadzwa MLAMBO, Renier MYBURGH
  • CONSTRUCT FOR EPIGENETIC MODIFICATION AND ITS USE IN THE SILENCING OF GENES
    Publication number: 20190024090
    Abstract: The present invention concerns a construct for epigenomic modification of genes comprising the following components: a) a Krüppel-associated box zinc finger protein or homologous, b) a DNA region capable of binding to the target gene or homologous, c) a human DNA methyltransferase DNMT3A or homologous and d) a murine DNA methyltransferase Dnmt3L or homologous whereby components a), b), c) and d) are linked to each other either directly or via at least one linker. The construct is a designer epigenome modifier which can be used to silence genes coding for a protein in leukocytes which avoids the internalization of HI viruses in immune cells.
    Type: Application
    Filed: April 11, 2018
    Publication date: January 24, 2019
    Applicant: Albert-Ludwigs-Universitaet Freiburg
    Inventors: Toni CATHOMEN, Claudio MUSSOLINO, Tatjana I. CORNU, Tafadzwa MLAMBO, Sandra NITSCH, Jamal ALZUBI, Marianna ROMITO
  • CONSTRUCT FOR EPIGENETIC MODIFICATION AND ITS USE IN THE SILENCING OF GENES
    Publication number: 20190024072
    Abstract: The present invention concerns a construct for epigenomic modification of genes that includes the following components: a) a Krüppel-associated box zinc finger protein or homologous, b) a DNA region capable of binding to the target gene or homologous, c) a human DNA methyltransferase DNMT3A or homologous and d) a murine DNA methyltransferase Dnmt3L or homologous whereby components a), b), c) and d) are linked to each other either directly or via at least one linker. The construct is a designer epigenome modifier which can be used to silence genes coding for a protein in leukocytes which avoids the internalization of HI viruses in immune cells.
    Type: Application
    Filed: July 24, 2017
    Publication date: January 24, 2019
    Applicant: Albert-Ludwigs-Universitaet Freiburg
    Inventors: Toni CATHOMEN, Claudio MUSSOLINO, Tatjana I. CORNU, Tafadzwa MLAMBO, Sandra NITSCH, Jamal ALZUBI, Marianna ROMITO