Abstract: There are provided herein a system and a computer implemented method for preventing, mitigating or treating partial/complete loss of effect of one or more drugs or medical devices administered to or used by a subject in need thereof due to adaptation, tolerance, and/or tachyphylaxis, and/or for preventing, mitigating or treating non-responsiveness to one or more drugs, maximizing therapeutic effect of one or more drugs, or for improving target or non-target organ/organs response to therapy, the system/method include (processing circuit configured to): receiving a plurality of physiological or pathological parameters of the subject; applying a machine learning algorithm on the plurality of physiological or pathological parameters; and determining a subject-specific administration regimen of a drug or a medical treatment, wherein the administration regimen comprises drug administration parameters, cell/tissue/organ stimulation parameters, adjuvant parameters or any combination thereof; wherein the administratio

Abstract: A method of classifying the severity of a coronaviral infection of a subject is disclosed. The method comprises measuring the TRAIL and/or IP10 protein level in a body liquid sample of the subject, wherein the level is indicative of the severity of the coronaviral infection. Managing treatments for coronaviral infections are also disclosed as well as measuring contagiousness of infections.

Abstract: The present disclosure provides systems regimens, devices and methods for improving organ function by challenged-exercise, training, and/or education and/or nutritional regimens, or devices intended for improving organ performance, and for prevention and treatment of loss of an effect to exercise regimens in healthy and chronic subjects, or lack of full responsiveness to exercise, training, nutritional or education regimens in subjects who wish to improve the function of their organs, or with chronic diseases. There are provided herein devices, systems, and methods for real time or delayed altering of the parameters of training regimens and/or time of administration and/or combining different exercise, training, nutrition or education regimens, for improving the long term effect of the regimen.

Abstract: There are provided herein a system and a computer implemented method for preventing, mitigating or treating partial/complete loss of effect of one or more drugs or medical devices administered to or used by a subject in need thereof due to adaptation, tolerance, and/or tachyphylaxis, and/or for preventing, mitigating or treating non-responsiveness to one or more drugs, maximizing therapeutic effect of one or more drugs, or for improving target or non-target organ/organs response to therapy, the system/method include (processing circuit configured to): receiving a plurality of physiological or pathological parameters of the subject; applying a machine learning algorithm on the plurality of physiological or pathological parameters; and determining a subject-specific administration regimen of a drug or a medical treatment, wherein the administration regimen comprises drug administration parameters, cell/tissue/organ stimulation parameters, adjuvant parameters or any combination thereof; wherein the administratio