Patents by Inventor Tai Hirakura

Tai Hirakura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CANCER VACCINE FORMULATION
    Publication number: 20220160849
    Abstract: The present invention provides a vaccine formulation for use in the prevention and/or treatment of a cancer, comprising a complex of a hyaluronic acid derivative having an introduced hydrophobic group, and an antigen.
    Type: Application
    Filed: January 29, 2020
    Publication date: May 26, 2022
    Inventors: Hiroshi SHIKU, Kazunari AKIYOSHI, Tai HIRAKURA, Tsuyoshi SHIMOBOJI, Takashi NAKAI, Sayan CHUANOI, Hideyuki TOGAWA
  • Derivative of hyaluronic acid modified with amino-carboxylic acid
    Patent number: 9243077
    Abstract: The present invention provides a hyaluronic acid derivative comprising disaccharide units of Formula (I), and a hyaluronic acid derivative/drug conjugate wherein one or more drugs are conjugated to the hyaluronic acid derivative.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: January 26, 2016
    Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Tomoko Yasugi, Yoshihiro Tampo, Kenji Yasugi, Tai Hirakura, Tsuyoshi Shimoboji
  • Hybrid gel comprising chemically crosslinked hyaluronic acid derivative and pharmaceutical composition comprising the same
    Patent number: 8987230
    Abstract: The present invention provides a composition comprising a hyaluronic acid derivative having a crosslinking group(s) and a hydrophilic polysaccharide derivative having a hydrophobic group(s), wherein the hyaluronic acid derivative having a crosslinking group(s) is prepared by crosslinkage formation reaction in hyaluronic acid or a derivative thereof having a crosslinkable group(s) in the presence of the hydrophilic polysaccharide derivative wherein the hydrophilic polysaccharide derivative may have a crosslinkable group(s).
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: March 24, 2015
    Assignees: National University Corporation Tokyo Medical and Dental University, Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kazunari Akiyoshi, Nobuyuki Morimoto, Tai Hirakura, Tsuyoshi Shimoboji
  • Hyaluronic acid derivative and pharmaceutical composition thereof
    Patent number: 8759322
    Abstract: The present invention provides a hydrophobic group-introduced hyaluronic acid derivative comprising at least one repeating unit represented by the formula (I): wherein R1, R2, R3, R4, Z, n, Ra, Y, and X1 are as defined in the specification.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: June 24, 2014
    Assignees: National University Corporation Tokyo Medical and Dental University, Chugau Seiyaku Kabushiki Kaisha
    Inventors: Kazunari Akiyoshi, Takashi Nakai, Tai Hirakura, Tsuyoshi Shimoboji
  • DERIVATIVE OF HYALURONIC ACID MODIFIED WITH AMINO-CARBOXYLIC ACID
    Publication number: 20130338352
    Abstract: The present invention provides a hyaluronic acid derivative comprising disaccharide units of Formula (I), and a hyaluronic acid derivative/drug conjugate wherein one or more drugs are conjugated to the hyaluronic acid derivative.
    Type: Application
    Filed: March 2, 2012
    Publication date: December 19, 2013
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Tomoko Yasugi, Yoshihiro Tampo, Kenji Yasugi, Tai Hirakura, Tsuyoshi Shimoboji
  • HYALURONIC ACID DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF
    Publication number: 20110212901
    Abstract: The present invention provides a hydrophobic group-introduced hyaluronic acid derivative comprising at least one repeating unit represented by the formula (I): wherein R1, R2, R3, R4, Z, n, Ra, Y, and X1 are as defined in the specification.
    Type: Application
    Filed: November 5, 2009
    Publication date: September 1, 2011
    Applicants: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNVERSITY, CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Kazunari Akiyoshi, Takashi Nakai, Tai Hirakura, Tsuyoshi Shimoboji
  • HYBRID GEL COMPRISING CHEMICALLY CROSSLINKED HYALURONIC ACID DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
    Publication number: 20100204102
    Abstract: The present invention provides a composition comprising a hyaluronic acid derivative having a crosslinking group(s) and a hydrophilic polysaccharide derivative having a hydrophobic group(s), wherein the hyaluronic acid derivative having a crosslinking group(s) is prepared by crosslinkage formation reaction in hyaluronic acid or a derivative thereof having a crosslinkable group(s) in the presence of the hydrophilic polysaccharide derivative wherein the hydrophilic polysaccharide derivative may have a crosslinkable group(s).
    Type: Application
    Filed: April 30, 2008
    Publication date: August 12, 2010
    Inventors: Kazunari Akiyoshi, Nobuyuki Morimoto, Tai Hirakura, Tsuyoshi Shimoboji
  • Hyaluronic acid modification products and drug carriers using them
    Patent number: 7767806
    Abstract: A hyaluronic acid modification product includes a polymer bonded to hyaluronic acid, the polymer being polylactic acid, polyglycolic acid or lactic acid-glycolic acid copolymer, providing a drug carrier which efficiently encapsulates low molecular weight drugs and provides sustained-release over a long term, control of blood residence, is well dispersible in an aqueous solution, and has excellent biocompatibility.
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: August 3, 2010
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tai Hirakura, Teruo Nakamura, Tsuyoshi Shimoboji
  • AGGREGABLE GLP-1 ANALOGUE AND SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION
    Publication number: 20090286724
    Abstract: The present invention provides a GLP-1 analogue having a high association-aggregability or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition to be used for preventing or treating diabetes, hyperglycemia, a diabetic complication caused by diabetes or hyperglycemia, or obesity, using the same.
    Type: Application
    Filed: October 26, 2006
    Publication date: November 19, 2009
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Hiroko Konishi, Tomoyuki Igawa, Tsuyoshi Shimoboji, Tai Hirakura
  • Hyaluronic acid modification products and drug carrier therefrom
    Publication number: 20070031503
    Abstract: There is provided a drug carrier which has solved the problems of conventional drug carriers, which can encapsulate a low molecular drug efficiently, which can control a sustained release period for a long term, which can control blood residence, which has high dispersibility in an aqueous solution, and which is not problematical in safety. A drug carrier, which comprises injectable fine particles minimal in agglomeration between the particles, and which has excellent biocompatibility, is also provided.
    Type: Application
    Filed: September 8, 2004
    Publication date: February 8, 2007
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Tai Hirakura, Teruo Nakamura