Abstract: Disclosed is a composition for reducing virus infection rates in crustaceans, which can be applied in prevention and/or treatment of viral infection in crustaceans, and therefore improves the survival rate. The composition comprises at least one of the antibodies that can bind specifically to virus, and the antibodies are selected from the group consisting of monoclonal antibody, phage display antibody and antibody produced by a recombinant organism. The monoclonal antibodies can be produced in a large scale from hybridoma cells with a bioreactor or by injecting into the abdominal cavities of mice. Alternatively, two other highly specific antibodies can be produced from phage clones and recombinant organisms. The composition can be used in the forms of therapeutic medicines, nutritious or feeding supplements in addition to feeds. Also, the composition can be used in an aqueous solution to expose the crustaceans to fulfill the needs of treatment and/or prevention of viral infection in crustaceans.