Abstract: An interactive information system includes: a first frame, a first interactive module arranged in the first frame, a second frame, a control module arranged in the second frame and configured to generate a graphic user interface (GUI) and to perform a function of the interactive information system based on the first user input; and a first internal cable connecting the first interactive module bridge board and the control module and configured to transmit the plurality of inter-frame signals between the first frame and the second frame. The first interactive module includes: a first display module for display of the GUI; a first touch input module configured to receive a first user input to the GUI; and a first interactive module bridge board configured to transmit a plurality of inter-frame signals comprising electrical signals of the first display module and the first touch input module.

Abstract: This invention relates to the use of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) in treating patients infected with a retrovirus.

Abstract: The present invention relates to novel methods for reducing toxicity associated with the administration of conventional "D" nucleoside compounds, including anti-HIV nucleosides and related therapeutic agents. Therapeutic methods which rely on conventional "D" nucleosides exhibit unexpectedly reduced toxicity when the methods include the co-administration of effective amounts of "L" nucleoside compounds. The method are particularly useful for the treatment of HIV infections and AIDS related symptoms in humans.

Abstract: The present invention relates to the surprising discovery that certain dideoxynucleoside analogs which contain a dideoxy ribofuranosyl moiety having an L-configuration (as opposed to the naturally occurring D- configuration) exhibit unexpected activity against Hepatitis B virus (HBV). In particular, the compounds according to the present invention show potent inhibition of the replication of the virus in combination with very low toxicity to the host cells (i.e., animal or human tissue). Compounds according to the present invention exhibit primary utility as agents for inhibiting the growth or replication of HBV, HIV and other retroviruses, most preferably HBV.

Abstract: The present invention relates to novel methods for reducing toxicity associated with the administration of conventional "D" nucleoside compounds, including anti-HIV nucleosides and related therapeutic agents. Therapeutic methods which rely on conventional "D" nucleosides exhibit unexpectedly reduced toxicity when the methods include the co-administration of effective amounts of "L" nucleoside compounds. The method are particularly useful for the treatment of HIV infections and AIDS related symptoms in humans.

Abstract: A method of treatment of tumors is provided based upon a compound of the formula ##STR1## wherein one of R.sup.1 is NHR.sup.4 or NR.sup.4 R.sup.5 or R.sup.3 is NHR.sup.4, NR.sub.4 R.sup.5 or OH, and the other is hydrogen;R.sup.2 is hydrogen or C.sub.1-4 lower alkyl;R.sup.4 is hydrogen, hydroxyl or C.sub.1-4 lower alkyl; andR.sup.5 is C.sub.1-4 lower alkyl; ora pharmaceutically acceptable salt or hydrate thereof.In a further aspect there is provided a method for the treatment of a tumor in a mammal which comprises administration of a compound which is 3- or 5-hydroxy-4-methyl-2-formylpyridine thiosemicarbazone to said mammal.

Abstract: The present invention relates to the surprising discovery that certain dideoxynucleoside analogs which contain a dideoxy ribofuranosyl moiety having an L-configuration (as opposed to the naturally occurring D- configuration) exhibit unexpected activity against Hepatitis B virus (HBV). In particular, the compounds according to the present invention show potent inhibition of the replication of the virus in combination with very low toxicity to the host cells (i.e., animal or human tissue). Compounds according to the present invention exhibit primary utility as agents for inhibiting the growth or replication of HBV, HIV and other retroviruses, most preferably HBV.

Abstract: The present invention relates to the surprising discovery that certain dideoxynucleoside analogs which contain a dideoxy ribofuranosyl moiety having an L-configuration (as opposed to the naturally occurring D-configuration) exhibit unexpected activity against Hepatitis B virus (HBV). In particular, the compounds according to the present invention show potent inhibition of the replication of the virus in combination with very low toxicity to the host cells (i.e., animal or human tissue). Compounds according to the present invention exhibit primary utility as agents for inhibiting the growth or replication of HBV, HIV and other retroviruses, most preferably HBV. The compound 1-(2,3-dideoxy-beta-L-ribofuranosyl)-5-fluorocytosine is shown to be a potent anti-HIV agent with low toxicity to host cells.

Abstract: The present invention relates to the surprising discovery that certain dideoxynucleoside analogs which contain a dideoxy ribofuranosyl moiety having an L-configuration (as opposed to the naturally occurring D- configuration) exhibit unexpected activity against Hepatitis B virus (HBV). In particular, the compounds according to the present invention show potent inhibition of the replication of the virus in combination with very low toxicity to the host cells (i.e., animal or human tissue). Compounds according to the present invention exhibit primary utility as agents for inhibiting the growth or replication of HBV, HIV and other retroviruses, most preferably HBV.

Abstract: A method of treatment of tumors is provided based upon a compound of the formula ##STR1##Some aspects of the invention were supported in part by U.S. Public Health Service Grant CA-02817 from the National Cancer Institute and support from the Northeast NMR Facility at Yale University insofar as the use of high resolution NMR spectra is concerned that was made possible by a grant from the Chemical Division of the National Science Foundation (Grant No. CHE-7916210).

Abstract: This invention relates to nucleoside and acyclo analogs containing 5- or 6-substituted 2-pyrazinone-4-N-oxide. These compounds are useful for treating various conditions including viral infections, cancer, fungal infections, bacterial infections, microbial infections and related disease states. This invention also relates to pharmaceutical formulations containing these compounds. In addition, this invention relates to methods of treating the above-described conditions in animals and in particular, humans.

Abstract: This disclosure describes the preparation of 3'-amino-2', 3'-dideoxyctidine and the pharmacologically acceptable salts thereof which are useful in inhibiting the growth of transplanted tumors in mammals.

Abstract: This invention relates to the use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with a retrovirus.

Abstract: The compounds of the formula: ##STR1## wherein R is selected from the group consisting of: (a) a substituent having the formula: ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen and --NO.sub.2,(b) a substituent having the formula: ##STR3## wherein R.sub.4 is hydrogen or an N(R').sub.2 substituent, wherein R' is an alkyl of 1 to 4 carbon atoms and R.sub.5 is CH or N,(c) alkyl of 1 to 18 carbon atoms,(d) halo-substituted alkyl of 1 to 6 carbon atoms,(e) styrenyl,(f) toluenyl, or(g) camphoryl.The compounds have been found to have anti-neoplastic activity for use in inhibiting the growth of tumors.

Abstract: This invention relates to 3'-azido-2',3'-dideoxy-5-halouridine, particularly, 3'-azido-2', 3'-dideoxy-5-bromouridine and 3'-azido-2',3'-dideoxy-5-iodouridine, and its use in treating patients infected with a retrovirus.

Abstract: This disclosure describes the preparation of 3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof which are useful in inhibiting the growth of transplanted tumors in mammals.

Abstract: This disclosure describes the preparation of therapeutically effective compositions of matter containing a nucleoside such as thymidine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) which are useful in inhibiting the growth of transplanted tumors in mammals.

Abstract: Alkyl and haloalkyl nitrosourea analogs of thymidine are useful in the treatment of cancers in mice.

Abstract: The known compound 5'-amino-5'-deoxythymidine and the pharmaceutically acceptable acid addition salts thereof are potent inhibitors of herpes simplex virus and compositions containing one or more of them are therapeutically useful.

Abstract: The compound 5-iodo-5'-amino-2',5'-dideoxycytidine and the pharmaceutically acceptable acid addition salts thereof are potent inhibitors of herpes simplex virus.