Abstract: The present invention provides: a modified FcRn-binding domain having an enhanced affinity for the Fc Receptor neonatal (FcRn) at neutral pH; an antigen-binding molecule comprising said FcRn-binding domain, which has low immunogenicity, high stability and form only a few aggregates; a modified antigen-binding molecule having an increased FcRn-binding activity at neutral or acidic pH without an increased binding activity at neutral pH for a pre-existing anti-drug antibody; use of the antigen-binding molecules for improving antigen-binding molecule-mediated antigen uptake into cells; use of the antigen-binding molecules for reducing the plasma concentration of a specific antigen; use of the modified FcRn-binding domain for increasing the total number of antigens to which a single antigen-binding molecule can bind before its degradation; use of the modified FcRn-binding domain for improving pharmacokinetics of an antigen-binding molecule; methods for decreasing the binding activity for a pre-existing anti-drug a

Abstract: Disclosed is a solution for quickly specifying an optical condition of a wafer to be inspected, and in particular, accelerating optical condition setting after obtaining a customer wafer.

Abstract: The present invention addresses the problem of quickly specifying an optical condition of a wafer to be inspected, and in particular, accelerating optical condition setting after obtaining a customer wafer.

Abstract: A design support device of the present invention is a design support device that is connected to a network to which both an input/output device where input/output regarding designing is performed and a design data accumulation device for storing design data regarding the designing are connected, the design support device including a network monitoring unit that monitors the network, detecting input/output data that is input/output between the network and the input/output device and outputting a monitoring log, and a design process list creation unit that extracts design processes based on a relationship between information regarding the input data and information regarding the output data included in the monitoring log, and creating and outputting a design process list by arranging the extracted design processes in a list.

Abstract: An object is to eliminate, through an inexpensive structure, degradation in withstand voltage performance and degradation in energization performance caused by heating in a vacuum circuit breaker. The vacuum circuit breaker includes a main circuit structure body having an insulation rod, a vacuum valve, a movable side terminal, and the like and an insulating holder for supporting the main circuit structure body. The insulating holder is a frame structure body having opening portions in the top and bottom surfaces and both side surfaces of the section in which the vacuum valve is disposed and the section in which the insulation rod is disposed.

Abstract: An object is to eliminate, through an inexpensive structure, degradation in withstand voltage performance and degradation in energization performance caused by heating in a vacuum circuit breaker. The vacuum circuit breaker includes a main circuit structure body having an insulation rod, a vacuum valve, a movable side terminal, and the like and an insulating holder for supporting the main circuit structure body. The insulating holder is a frame structure body having opening portions in the top and bottom surfaces and both side surfaces of the section in which the vacuum valve is disposed and the section in which the insulation rod is disposed.

Abstract: A design support device of the present invention is a design support device that is connected to a network to which both an input/output device where input/output regarding designing is performed and a design data accumulation device for storing design data regarding the designing are connected, the design support device including a network monitoring unit that monitors the network, detecting input/output data that is input/output between the network and the input/output device and outputting a monitoring log, and a design process list creation unit that extracts design processes based on a relationship between information regarding the input data and information regarding the output data included in the monitoring log, and creating and outputting a design process list by arranging the extracted design processes in a list.

Abstract: In an elevator wire rope 1 structured by twisting a plurality of schenkels 3, each schenkel 3 being formed by twisting a plurality of strands 2, each strand 2 being formed by twisting a plurality of fine steel wires 2a to 2g, the interior of the wire rope being filled with a resin 4, and the surface of the wire rope being covered with a resin 5, wherein the direction in which the fine steel wires 2a to 2g and the strands 2 are twisted and the direction in which the schenkels 3 are twisted are mutually opposite, and the diameter d4 of the inscribed circle of the plurality of twisted schenkels 3 is smaller than the diameter d2 of the schenkel 3.

Abstract: In an elevator wire rope 1 structured by twisting a plurality of schenkels 3, each schenkel 3 being formed by twisting a plurality of strands 2, each strand 2 being formed by twisting a plurality of fine steel wires 2a to 2g, the interior of the wire rope being filled with a resin 4, and the surface of the wire rope being covered with a resin 5, wherein the direction in which the fine steel wires 2a to 2g and the strands 2 are twisted and the direction in which the schenkels 3 are twisted are mutually opposite, and the diameter d4 of the inscribed circle of the plurality of twisted schenkels 3 is smaller than the diameter d2 of the schenkel 3.

Abstract: An elevator is capable of transmitting signals between an elevator control unit and a car control unit without using tail cords. Resin-coated ropes for suspending an elevator car and a counterweight comprise conductive metal wires. Transmitter-receivers use the conductive metal wires of the ropes for contactless signal transmission. The conductive metal wires of the two ropes are connected in rope-anchoring parts to form an electrical closed loop for signal transmission.

Abstract: Provided is a syringe destruction apparatus comprising a syringe needle shearing section and a barrel breaking section, wherein the needle and barrel of a used syringe are broken by movable blades driven by a rotating cam plate to prevent the syringe from being reused, thereby it is possible to prevent a used syringe from being abused in narcotic crimes.