Patents by Inventor Taichiro Komeno

Taichiro Komeno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclization to form cephem ring and azetidinone intermediates therefor
    Patent number: 4440683
    Abstract: An intermediate represented by following formula for synthesizing 3-hydroxy-3-cephem compounds. ##STR1## wherein A and B each is a hydrogen or amine substituent; R is a hydrogen or thiol substituent; Nal is a halogen; X is a hydroxy or carboxy protecting group; the broken line between A and R shows that when R and B are hydrogens, and A is a carboxylic acyl, the substituents can be combined to form an azetidimethiazoline bicyclic ring; and the enamine derivatives thereof.
    Type: Grant
    Filed: January 11, 1982
    Date of Patent: April 3, 1984
    Assignee: Shionogi & Co., Ltd.
    Inventors: Teruji Tsuji, Yoshio Hahashima, Mitsuru Yoshioka, Masayuki Narisada, Hiroshi Tanida, Taichiro Komeno, Wataru Nagata
  • Cyclization process to form cephem ring
    Patent number: 4346218
    Abstract: An intermediate represented by following formula for synthesizing 3-hydroxy-3-cephem compounds ##STR1## wherein A and B each is a hydrogen or amino substituent; R is a hydrogen or thiol substituent; Hal is a halogen; X is a hydroxy or carboxy protecting group; the broken line between A and R shows that when R and B are hydrogens, and A is a carboxylic acyl, the substituents can be combined to form an azetidinothiazoline bicyclic ring; and the enamine derivatives thereof.
    Type: Grant
    Filed: February 27, 1980
    Date of Patent: August 24, 1982
    Assignee: Shionogi & Co., Ltd.
    Inventors: Teruji Tsuji, Yoshio Hamashima, Mitsuru Yoshioka, Masayuki Narisada, Hiroshi Tanida, Taichiro Komeno, Wataru Nagata
  • Cyclization to form cephem ring and intermediates therefor
    Patent number: 4332722
    Abstract: An intermediate represented by the following formula, for synthesizing --3-hydroxy-3-cephem compounds. ##STR1## wherein A and B each is a hydrogen or amino substituent; R is a hydrogen or thiol substituent; Hal is a halogen; X is a hydroxy or carboxy protecting group; the broken line between A and R shows that when R and B are hydrogens, and A is a carboxylic acyl, the substituents can be combined to form an azetidinothiazoline bicyclic ring; and the enamine derivatives thereof.
    Type: Grant
    Filed: February 27, 1980
    Date of Patent: June 1, 1982
    Assignee: Shionogi & Co., Ltd.
    Inventors: Teruji Tsuji, Yoshio Hamashima, Mitsuru Yoshioka, Masayuki Narisada, Hiroshi Tanida, Taichiro Komeno, Wataru Nagata
  • Cyclization to form cephem ring and intermediates therefor
    Patent number: 4160085
    Abstract: Intermediates represented by the following formulas are useful for synthesizing 3-hydroxy-3-cephem compounds ##STR1## wherein A and B each is a hydrogen or amino substituent; R is a hydrogen or thiol substituent; Hal is a halogen; X is a hydroxy or carboxy protecting group; the broken line between A and R shows that when R and B are hydrogens, and A is a carboxylic acyl, the substituents can be combined to form an azetidinothiazoline bicyclic ring; and the enamine derivatives thereof.
    Type: Grant
    Filed: December 1, 1977
    Date of Patent: July 3, 1979
    Assignee: Shionogi & Co., Ltd.
    Inventors: Teruji Tsuji, Yoshio Hamashima, Mitsuru Yoshioka, Masayuki Narisada, Hiroshi Tanida, Taichiro Komeno, Wataru Nagata
  • Method for the hydrolysis of azetidinothiazoline compounds
    Patent number: 4130557
    Abstract: A process for preparing compounds having the formula: ##STR1## WHEREIN R is phenoxymethyl or benzyl; R.sub.2 is 1-methoxyethylidene, 1-hydroxyethylidene, or 1,1-dimethoxyethylidene; andR.sub.3 is trichloroethyl, diphenylmethyl, p-nitrobenzyl, trityl, phenyl, naphthyl, or trimethylstannyl;Which comprises treating a compound of the following formula: ##STR2## where R, R.sub.2 and R.sub.3 are as defined above, WITH AgClO.sub.4, AgBF.sub.4, AgIO.sub.4, AgPF.sub.6, CF.sub.3 COOAg, CH.sub.3 SO.sub.3 Ag, CF.sub.3 SO.sub.3 Ag, CH.sub.3 COOAg, or AgNO.sub.3 in aqueous dioxane, aqueous tetrahydrofuran or mixtures thereof.
    Type: Grant
    Filed: January 29, 1976
    Date of Patent: December 19, 1978
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yoshio Hamashima, Teruji Tsuji, Mitsuru Yoshioka, Masayuki Narisada, Taichiro Komeno, Hiroshi Tanida, Wataru Nagata
  • Certain 7-oxo-4-thio-2,6-diazabicyclo-3,2,0-hept-2-ene compounds
    Patent number: 4079181
    Abstract: An intermediate represented by following formula for synthesizing 3-hydroxy-3-cephem compounds. ##STR1## wherein A and B each is a hydrogen or amino substituent; R is a hydrogen or thiol substituent; Hal is a halogen; X is a hydroxy or carboxy protecting group; the broken line between A and R shows that when R and B are hydrogens, and A is a carboxylic acyl, the substituents can be combined to form an azetidinothiazoline bicyclic ring; and the enamine derivatives thereof.
    Type: Grant
    Filed: February 17, 1976
    Date of Patent: March 14, 1978
    Assignee: Shionogi & Co., Ltd.
    Inventors: Teruji Tsuji, Yoshio Hamashima, Mitsuru Yoshioka, Masayuki Narisada, Hiroshi Tanida, Taichiro Komeno, Wataru Nagata
  • Method for cyclization to give cephem ring
    Patent number: 4066641
    Abstract: A compound represented by ##STR1## is treated with a base to give an antibacterial cephem compound represented by ##STR2## (wherein A is amino or substituted amino;Cob is carboxy or protected carboxy;Rs is substituted thio;Y is an electron-attracting group selected from acyloxy, halogen, cyano, nitro, and nitroso; andThe dotted line shows .DELTA..sup.2 or .DELTA..sup.3).
    Type: Grant
    Filed: July 21, 1976
    Date of Patent: January 3, 1978
    Inventors: Yoshio Hamashima, Mitsuru Yoshioka, Hiroshi Tanida, Teruji Tsuji, Masayuki Narisada, Taichiro Komeno, Wataru Nagata