Abstract: The present disclosure provides GIP receptor agonist peptide compounds having an activating action on GIP receptors and use of the GIP receptor agonist peptide as a medicament for the treatment and/or prevention of diabetes, obesity, emesis, or a symptom or condition associated with diabetes, obesity, or emesis. Specifically, a GIP receptor agonist peptide containing a sequence represented by the formula (I) or a salt thereof, and a medicament comprising the same are provided. Formula I: P1-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-A41-P2 (SEQ ID NO: 4), or a salt thereof, wherein each symbol is as defined herein, with the proviso that the GIP receptor agonist peptide does not have an amino acid sequence as provided in SEQ ID NOs: 328-893.

Abstract: The present invention provides an orthodontic appliance having a load applying mechanism. To correct malocclusion, the load applying mechanism may include a projection fixed to the specified tooth in the teeth so as to project from the specified tooth in the teeth.

Abstract: The present invention concerns an orthodontic appliance for accelerating the tooth aligning effect and shortening the treatment period, and has an object to provide an appliance which can bring about higher aligning effect than usual ways by giving vibration to tooth to be aligned to activate bone remodeling of the targeted tooth and the alveolar bone and enhance the shift of the tooth. This appliance includes a vibrating element and a dental mouthpiece having the vibrating element built therein. The provision of the vibrating element in the dental mouthpiece facilitates the application of vibration and handling, and continues the treatment safely even at home. The inner shape of the dental mouthpiece serves aligning treatment as well as acceleration of the effect.

Abstract: The present invention concerns an orthodontic appliance for accelerating the tooth aligning effect and shortening the treatment period, and has an object to provide an appliance which can bring about higher aligning effect than usual ways by giving vibration to tooth to be aligned to activate bone remodeling of the targeted tooth and the alveolar bone and enhance the shift of the tooth. This appliance includes a vibrating element and a dental mouthpiece having the vibrating element built therein. The provision of the vibrating element in the dental mouthpiece facilitates the application of vibration and handling, and continues the treatment safely even at home. The inner shape of the dental mouthpiece serves aligning treatment as well as acceleration of the effect.

Abstract: The present invention concerns an orthodontic appliance for accelerating the tooth aligning effect and shortening the treatment period, and has an object to provide an appliance which can bring about higher aligning effect than usual ways by giving vibration to tooth to be aligned to activate bone remodeling of the targeted tooth and the alveolar bone and enhance the shift of the tooth. This appliance includes a vibrating element and a dental mouthpiece having the vibrating element built therein. The provision of the vibrating element in the dental mouthpiece facilitates the application of vibration and handling, and continues the treatment safely even at home. The inner shape of the dental mouthpiece serves aligning treatment as well as acceleration of the effect.

Abstract: The present invention aims to provide an orthodontic appliance capable of efficiently applying vibration to teeth to be aligned and enabling a treatment to be easily and safely continued even at home. This appliance is provided with a load applying mechanism and a vibration generating actuator. The load applying mechanism is mounted on teeth to apply a load for the malocclusion correction to a specified tooth in the teeth. The vibration generating actuator includes a contact portion that is inserted into a buccal cavity containing the teeth and can come into contact with a part of the load applying mechanism corresponding to the specified tooth or the specified tooth, and applies a vibration force from the contact portion to the specified tooth or the part of the load applying mechanism.

Abstract: The present invention provides an orthodontic appliance having a load applying mechanism. To correct malocclusion, the load applying mechanism may include a projection fixed to the specified tooth in the teeth so as to project from the specified tooth in the teeth.

Abstract: The present invention concerns an orthodontic appliance for accelerating the tooth aligning effect and shortening the treatment period, and has an object to provide an appliance which can bring about higher aligning effect than usual ways by giving vibration to tooth to be aligned to activate bone remodeling of the targeted tooth and the alveolar bone and enhance the shift of the tooth. This appliance includes a vibrating element and a dental mouthpiece having the vibrating element built therein. The provision of the vibrating element in the dental mouthpiece facilitates the application of vibration and handling, and continues the treatment safely even at home. The inner shape of the dental mouthpiece serves aligning treatment as well as acceleration of the effect.

Abstract: The present invention concerns an orthodontic appliance for accelerating the tooth aligning effect and shortening the treatment period, and has an object to provide an appliance which can bring about higher aligning effect than usual ways by giving vibration to tooth to be aligned to activate bone remodeling of the targeted tooth and the alveolar bone and enhance the shift of the tooth. This appliance includes a vibrating element and a dental mouthpiece having the vibrating element built therein. The provision of the vibrating element in the dental mouthpiece facilitates the application of vibration and handling, and continues the treatment safely even at home. The inner shape of the dental mouthpiece serves aligning treatment as well as acceleration of the effect.

Abstract: The present invention aims to provide an orthodontic appliance capable of aligning teeth within a shorter period of time than usual without using braces including an orthodontic wire and brackets. This appliance is provided with a dental mouthpiece mountable on teeth and a vibrating element. The dental mouthpiece is so shaped as to apply a biasing force in an aligning direction to a tooth to be aligned in the teeth while being mounted on the teeth. The vibrating element is attached to the dental mouthpiece, generates mechanical vibration and applies the vibration to the tooth to be aligned, thereby activating the bone remodeling of a target tooth and an alveolar bone to promote an orthodontic effect.

Abstract: An orthodontic appliance capable of remarkably shortening a period of treatment and reducing burdens on patients is provided with braces to be mounted on a specified tooth included in teeth, a magnetic field generator and a magnetic element to be attached to the teeth. The magnetic element vibrates in response to a magnetic field generated by the magnetic field generator and applies the vibration thereof to the tooth on which the braces are mounted.

Abstract: The present invention aims to provide an orthodontic appliance capable of efficiently applying vibration to teeth to be aligned and enabling a treatment to be easily and safely continued even at home. This appliance is provided with a load applying mechanism and a vibration generating actuator. The load applying mechanism is mounted on teeth to apply a load for the malocclusion correction to a specified tooth in the teeth. The vibration generating actuator includes a contact portion that is inserted into a buccal cavity containing the teeth and can come into contact with a part of the load applying mechanism corresponding to the specified tooth or the specified tooth, and applies a vibration force from the contact portion to the specified tooth or the part of the load applying mechanism.