Patents by Inventor Taiji OASHI

Taiji OASHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligonucleotide
    Patent number: 10378011
    Abstract: An oligonucleotide having improved affinity for AGO2 is disclosed. The oligonucleotide has a nucleotide residue or a nucleoside residue represented by formula (I) wherein X1 is an oxygen atom or the like, R1 is formula (IIA), wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like, or formula (IVA) wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like, or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like at the 5? end thereof, and the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3. A method for improving the knockdown activity of an oligonucleotide wherein the oligonucleotide has a knockdown activity against an mRNA encoding a protein involved in a disease.
    Type: Grant
    Filed: September 2, 2013
    Date of Patent: August 13, 2019
    Assignee: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Fumikazu Shinohara, Asana Makino, Junichiro Yamamoto, Taiji Oashi, Michihiko Suzuki, Jun-ichi Saito, Takahiro Nakajima, Tomoyuki Nishikawa, Masayoshi Nakoji, Yuichi Takahashi
  • Oligonucleotide having non-natural nucleotide at 5?-terminal thereof
    Patent number: 10342819
    Abstract: An oligonucleotide having a nucleotide residue or a nucleoside residue represented by formula (I) {wherein X1 is an oxygen atom or the like, R1 is formula (IIA) (wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like), formula (IVA) (wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like), or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like, or formula (VI) (wherein n2 is 1, 2 or 3)} at the 5? end thereof, wherein the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3, is provided.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: July 9, 2019
    Assignee: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Fumikazu Shinohara, Asana Makino, Junichiro Yamamoto, Takahiro Nakajima, Taiji Oashi, Michihiko Suzuki, Jun-ichi Saito, Tomoyuki Nishikawa, Masayoshi Nakoji, Yuichi Takahashi, Yasuo Kouda
  • OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF
    Publication number: 20170354673
    Abstract: An oligonucleotide having a nucleotide residue or a nucleoside residue represented by formula (I) {wherein X1 is an oxygen atom or the like, R1 is formula (IIA) (wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like), formula (IVA) (wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like), or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like, or formula (VI) (wherein n2 is 1, 2 or 3)} at the 5? end thereof, wherein the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3, is provided.
    Type: Application
    Filed: March 3, 2015
    Publication date: December 14, 2017
    Applicant: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Fumikazu SHINOHARA, Asana MAKINO, Junichiro YAMAMOTO, Takahiro NAKAJIMA, Taiji OASHI, Michihiko SUZUKI, Jun-ichi SAITO, Tomoyuki NISHIKAWA, Masayoshi NAKOJI, Yuichi TAKAHASHI, Yasuo KOUDA
  • OLIGONUCLEOTIDE
    Publication number: 20150376611
    Abstract: The present invention provides an oligonucleotide having improved affinity for AGO2, and the like. The oligonucleotide has a nucleotide residue or a nucleoside residue represented by formula (I) {wherein X1 is an oxygen atom or the like, R1 is formula (IIA) (wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like) or formula (IVA) (wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like), or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like} at the 5? end thereof, and the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3.
    Type: Application
    Filed: September 2, 2013
    Publication date: December 31, 2015
    Inventors: Fumikazu SHINOHARA, Asana MAKINO, Junichiro YAMAMOTO, Taiji OASHI, Michihiko SUZUKI, Jun-ichi SAITO, Takahiro NAKAJIMA, Tomoyuki NISHIKAWA, Masayoshi NAKOJI, Yuichi TAKAHASHI
  • OLIGONUCLEOTIDE
    Publication number: 20140330004
    Abstract: An oligonucleotide, which has a nucleotide residue or a nucleoside residue represented by formula (I) at the 5? end thereof, wherein the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue via the oxygen atom at position 3, or the like; wherein X represents an oxygen atom or the like, R1 represents formula (II) wherein Y1 represents a nitrogen atom or the like, R5 represents halogen or the like, R6 and R7 may be the same or different, and each represents a hydrogen atom or the like, and R3 represents a hydrogen atom or the like.
    Type: Application
    Filed: December 6, 2013
    Publication date: November 6, 2014
    Applicant: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Fumikazu SHINOHARA, Asana MAKINO, Junichiro YAMAMOTO, Taiji OASHI, Michihiko SUZUKI, Jun-ichi SAITO