Patents by Inventor Taiki AOSHI

Taiki AOSHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-aggregating immunostimulatory oligonucleotides
    Patent number: 11268098
    Abstract: Provided are non-aggregating immunostimulatory oligonucleotides. The present invention also provides a delivery agent for an immunostimulatory-oligonucleotide nucleic acid medicine, said delivery agent including a nucleic acid that contains a phosphorothioated nucleotide. According to another aspect, the present invention further provides an oligonucleotide including a bioactive core, and a nucleic acid that contains a phosphorothioated nucleotide. The present invention yet further provides an immunostimulator including the bioactive core of a type A/D, type B/K, or type C immunostimulatory oligonucleotide.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: March 8, 2022
    Assignees: National Institutes of Biomedical Innovation, Health and Nutrition, GeneDesign, Inc.
    Inventors: Ken Ishii, Taiki Aoshi, Hideaki Sato
  • LIPID PARTICLE CONTAINING A-TYPE CpG OLIGODEOXYNUCLEOTIDE
    Publication number: 20210261964
    Abstract: An object is to provide a technology that can stably exhibit the effects of A-type CpG oligodeoxynucleotides. The object can be achieved by a lipid particle comprising an A-type CpG oligodeoxynucleotide.
    Type: Application
    Filed: July 18, 2019
    Publication date: August 26, 2021
    Applicants: THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY, OSAKA UNIVERSITY, TEIKYO UNIVERSITY
    Inventors: Taiki AOSHI, Shohei KOYAMA, Ryo SUZUKI
  • Complex containing oligonucleotide having immunopotentiating activity and use thereof
    Patent number: 11015202
    Abstract: The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3?-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and ?-1,3-glucan.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: May 25, 2021
    Assignees: NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Ken Ishii, Kouji Kobiyama, Taiki Aoshi, Fumihiko Takeshita, Yuji Kasuya, Takako Niwa, Makoto Koizumi
  • COMPLEX CONTAINING OLIGONUCLEOTIDE HAVING IMMUNOPOTENTIATING ACTIVITY AND USE THEREOF
    Publication number: 20190112606
    Abstract: The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3?-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and ?-1,3-glucan.
    Type: Application
    Filed: December 20, 2018
    Publication date: April 18, 2019
    Applicants: NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Ken ISHII, Kouji KOBIYAMA, Taiki AOSHI, Fumihiko TAKESHITA, Yuji KASUYA, Takako NIWA, Makoto KOIZUMI
  • Complex containing oligonucleotide having immunopotentiating activity and use thereof
    Patent number: 10202606
    Abstract: The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3?-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and ?-1,3-glucan.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: February 12, 2019
    Assignees: NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Ken Ishii, Kouji Kobiyama, Taiki Aoshi, Fumihiko Takeshita, Yuji Kasuya, Takako Niwa, Makoto Koizumi
  • USE OF NUCLEIC ACID-POLYSACCHARIDE COMPLEXES HAVING IMMUNOPOTENTIATING ACTIVITY AS ANTI-TUMOR DRUG
    Publication number: 20180256630
    Abstract: The present invention provides an anticancer agent to be used as a single agent. More specifically, the present invention provides an anticancer agent containing complexes that contain (a) an oligodeoxynucleotide containing a humanized K-type CpG oligodeoxynucleotide and polydeoxyadenylic acid, the polydeoxyadenylic acid being located on the 3? side of the humanized K-type CpG oligodeoxynucleotide, and (b) ?-1,3-glucan. The present invention is preferably characterized in that the anticancer agent is administered without a cancer antigen.
    Type: Application
    Filed: December 26, 2014
    Publication date: September 13, 2018
    Inventors: Ken Ishii, Taiki Aoshi, Kouji Kobiyama
  • NON-AGGREGATING IMMUNOSTIMULATORY OLIGONUCLEOTIDES
    Publication number: 20170362591
    Abstract: Provided are non-aggregating immunostimulatory oligonucleotides. The present invention also provides a delivery agent for an immunostimulatory-oligonucleotide nucleic acid medicine, said delivery agent including a nucleic acid that contains a phosphorothioated nucleotide. According to another aspect, the present invention further provides an oligonucleotide including a bioactive core, and a nucleic acid that contains a phosphorothioated nucleotide. The present invention yet further provides an immunostimulator including the bioactive core of a type A/D, type B/K, or type C immunostimulatory oligonucleotide.
    Type: Application
    Filed: December 24, 2015
    Publication date: December 21, 2017
    Inventors: Ken Ishii, Taiki Aoshi, Hideaki Sato
  • COMPLEX CONTAINING OLIGONUCLEOTIDE HAVING IMMUNOPOTENTIATING ACTIVITY AND USE THEREOF
    Publication number: 20160208260
    Abstract: The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3?-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and ?-1,3-glucan.
    Type: Application
    Filed: September 19, 2014
    Publication date: July 21, 2016
    Applicants: NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEAL TH AND NUTRITION, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Ken ISHII, Kouji KOBIYAMA, Taiki AOSHI, Fumihiko TAKESHITA, Yuji KASUYA, Takako NIWA, Makoto KOIZUMI