Patents by Inventor Taikyun Rho

Taikyun Rho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium compounds
    Patent number: 6790859
    Abstract: The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: September 14, 2004
    Assignee: Alteon Incorporated
    Inventors: Dilip R. Wagle, Sheng-Ding Fang, Taikyun Rho, John J. Egan, Sara Vasan, Peter Ulrich, Anthony Cerami
  • Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium compounds
    Publication number: 20030176417
    Abstract: The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.
    Type: Application
    Filed: January 21, 2003
    Publication date: September 18, 2003
    Inventors: Dilip R. Wagle, Sheng-Ding Fang, Taikyun Rho, John J. Egan, Sara Vasan, Peter Ulrich, Anthony Cerami
  • Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts
    Publication number: 20020160992
    Abstract: The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.
    Type: Application
    Filed: October 23, 2001
    Publication date: October 31, 2002
    Inventors: Dilip R. Wagle, Sheng-Ding Fang, Taikyun Rho, John J. Egan, Sara Vasan, Peter Ulrich, Anthony Cerami
  • Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium compounds
    Patent number: 6319934
    Abstract: The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: November 20, 2001
    Assignee: Alteon, Inc.
    Inventors: Dilip R. Wagle, Sheng-Ding Fang, Taikyun Rho, John J. Egan, Sara Vasan, Peter Ulrich, Anthony Cerami
  • Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts
    Patent number: 6121300
    Abstract: The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.
    Type: Grant
    Filed: November 10, 1998
    Date of Patent: September 19, 2000
    Inventors: Dilip R. Wagle, Sheng-Ding Fang, Taikyun Rho, John J. Egan, Sara Vasan, Peter Ulrich, Anthony Cerami
  • Synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole and analogs thereof
    Patent number: 5856511
    Abstract: The present invention relates to a practical and facile synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole (FFI) and analogs thereof. The synthesis utilized a novel hydrazinium salt as an intermediate reaction product which facilitates the isolation of purified product in high yields.
    Type: Grant
    Filed: August 6, 1997
    Date of Patent: January 5, 1999
    Assignee: Alteon Inc.
    Inventors: Taikyun Rho, Michael E. Lankin, David H. Shih, Claire M. Lankin