Abstract: A piperidine derivative having the formula (I): ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different from each other, are (i) a not-substituted phenyl group or a phenyl group substituted by a halogen atom, trifluoromethyl group, a C.sub.1-5 alkyl group or a C.sub.1-5 alkoxyl group, (ii) a C.sub.3-7 cycloalkyl group, (iii) pyridyl group or (iv) thienyl group, R.sup.3 is (i) hydrogen atom, (ii) a halogen atom, (iii) a C.sub.1-4 alkyl group or (iv) a C.sub.1-4 alkoxyl group, R.sup.4 is (i) hydrogen atom or (ii) a C.sub.1-4 alkyl group. R.sup.5 is (i) a not-substituted C.sub.1-5 alkyl group or a C.sub.1-5 alkyl group substituted by a halogen atom, (ii) phenyl group or (iii) thienyl group and Z is (i) a C.sub.1-6 alkylene group, (ii) a C.sub.2-6 alkenylene group or (iii) a C.sub.3-6 alkynylene group or a pharmacologically acceptable salt thereof. According to the present invention, an anti-allergic agent and a therapeutic agent for ischemic heart disease without toxicity can be provided.

Abstract: Disclosed are novel opthalmic solutions useful for the treatment of ocular hypertension and glaucoma. These contain mabuterol as a preferred active ingredient.

Abstract: Herein disclosed is a transverse resonance measurement device for measuring the Young's modulus and/or internal friction of the plate specimen of a material over a wide temperature range even if the material is nonconductive, e.g., ceramics, wood or plastics. Platinum paste is applied to one side of a plate specimen to be measured, and is baked into a platinum electrode.

Abstract: Novel biologically active substances prepared by dissociating the protein obtained from the cultivation of the microorganism Bordetella and having insulin secretion promoting action as well as glucose tolerance improving action for mammals.