Patents by Inventor Tairo OGURA
Tairo OGURA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230400440Abstract: A mass spectrometry control device includes a deriver that derives, based on a set of allergens that are detectable without being distinguished from one another among a plurality of allergens to be detected and data that indicates a plurality of peptides produced by subjecting each allergen to a cleavage process, first peptides produced in common when the plurality of allergens included in the set are subjected to the cleavage process and at least one of parameters for detecting the first peptides, and a setter that sets a condition of mass spectrometry to detect at least one of the first peptides.Type: ApplicationFiled: August 24, 2020Publication date: December 14, 2023Applicant: SHIMADZU CORPORATIONInventor: Tairo OGURA
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Publication number: 20230384263Abstract: An analysis device for data obtained in mass spectrometry, includes an information acquirer that acquires detection information representing a peptide that is detected when a sample is subjected to a cleavage process and then subjected to mass spectrometry, and an information producer that produces allergen information in regard to an allergen included in the sample based on the detection information and data representing a peptide that is produced when each allergen is subjected to the cleavage process, wherein the information producer produces the allergen information based on a combination of a plurality of peptides in a case in which the plurality of peptides produced from one allergen in the data are detected.Type: ApplicationFiled: August 24, 2020Publication date: November 30, 2023Applicant: SHIMADZU CORPORATIONInventor: Tairo OGURA
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Publication number: 20230184643Abstract: A method for identifying a target component of interest in a specimen by probe electrospray ionization mass spectrometry, including: (1) adsorbing the target component of interest onto an extraction phase for adsorbing the target component of interest from the specimen by immersing a probe into the specimen, wherein the probe is at least partially coated with the extraction phase; (2) removing the probe from the specimen and optionally quick rising it by dipping in or spraying water or acetone/water mixtures; (3) adhering solvent to the extraction phase; (4) desorbing the target component of interest into the solvent from the extraction phase; (5) electrospraying the target component of interest desorbed in the solvent adhered to the probe on the ionization source at atmospheric pressure by applying a voltage to the probe to spray aerosolized ionized droplets out of the probe; and (6) identifying the target component of interest present in the aerosolized ionized droplets.Type: ApplicationFiled: April 3, 2021Publication date: June 15, 2023Applicants: SHIMADZU CORPORATION, JP SCIENTIFIC LIMITEDInventors: Janusz B. PAWLISZYN, Milaan THIRUKUMARAN, Varoon SINGH, Yohei ARAO, Yuka FUJITO, Masayuki NISHIMURA, Tairo OGURA
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Patent number: 11243193Abstract: A supercritical fluid device includes an analytical channel, a liquid delivery part for delivering a mobile phase constituting a supercritical fluid in the analytical channel, a back pressure regulator for controlling a pressure of the analytical channel so as to cause the mobile phase in the analytical channel to reach a supercritical state, a sample injecting device that includes a sample holder for holding a sample and a switching valve for switching between a state where the sample holder is arranged on the analytical channel and a state where the sample holder is not arranged on the analytical channel, a bypass channel whose one end is connected to a position upstream of the sample injecting device and whose other end is connected to a position downstream of the sample injecting device on the analytical channel, and an analytical column for separating a sample introduced by the sample injecting device into individual components, the analytical column is provided downstream of the position to which the otType: GrantFiled: March 17, 2017Date of Patent: February 8, 2022Assignee: SHIMADZU CORPORATIONInventors: Yuka Fujito, Tairo Ogura, Kenichiro Tanaka
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Patent number: 11049711Abstract: A mass spectrometer having a triple ionization interface for ionizing sample components is provided. The ionization interface of the mass spectrometer includes a means for ionizing sample components via electrostatic ionization, atmospheric pressure chemical ionization, and laser diode thermal desorption.Type: GrantFiled: June 4, 2018Date of Patent: June 29, 2021Assignees: SHIMADZU CORPORATION, PHYTRONIX TECHNOLOGIES INC.Inventors: Tairo Ogura, Jean Lacoursiere, Pierre Picard
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Publication number: 20210151311Abstract: A mass spectrometer having a triple ionization interface for ionizing sample components is provided. The ionization interface of the mass spectrometer includes a means for ionizing sample components via electrostatic ionization, atmospheric pressure chemical ionization, and laser diode thermal desorption.Type: ApplicationFiled: June 4, 2018Publication date: May 20, 2021Applicants: SHIMADZU CORPORATION, PHYTRONIX TECHNOLOGIES INC.Inventors: Tairo OGURA, Jean LACOURSIERE, Pierre PICARD
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Patent number: 10615017Abstract: A mass spectrometer including a memory unit storing information indicating combinations of precursor ions for CIDs in respective stages. If an MS1 spectrum on which CID is not performed is obtained during execution of an analysis, a precursor ion selector determines whether an ion registered as a precursor ion for the first-stage CID exists on the MS1 spectrum, based on the list held in the memory unit. If the ion exists, an MS2 analysis in which the ion is set as a precursor ion is immediately executed. Subsequently, the precursor ion selector determines whether or not an ion registered as a precursor ion for the second-stage CID in association with the precursor ion for the first-stage CID exists on an MS2 spectrum. If the ion exists, an MS3 analysis in which the ion is set as a precursor ion is immediately executed, so that an MS3 spectrum is acquired.Type: GrantFiled: March 26, 2013Date of Patent: April 7, 2020Assignee: SHIMADZU CORPORATIONInventor: Tairo Ogura
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Publication number: 20200025725Abstract: A supercritical fluid device includes an analytical channel, a liquid delivery part for delivering a mobile phase constituting a supercritical fluid in the analytical channel, a back pressure regulator for controlling a pressure of the analytical channel so as to cause the mobile phase in the analytical channel to reach a supercritical state, a sample injecting device that includes a sample holder for holding a sample and a switching valve for switching between a state where the sample holder is arranged on the analytical channel and a state where the sample holder is not arranged on the analytical channel, a bypass channel whose one end is connected to a position upstream of the sample injecting device and whose other end is connected to a position downstream of the sample injecting device on the analytical channel, and an analytical column for separating a sample introduced by the sample injecting device into individual components, the analytical column is provided downstream of the position to which the otType: ApplicationFiled: March 17, 2017Publication date: January 23, 2020Applicant: SHIMADZU CORPORATIONInventors: Yuka FUJITO, Tairo OGURA, Kenichiro TANAKA
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Publication number: 20170343519Abstract: A liquid chromatograph includes: a concentration column for capturing a target component; an analysis column for separating the target component from other components; first passage-switching units for switching between the state of forming a passage through which a sample-introduction mobile phase containing the liquid sample is fed to the concentration column, and the state of forming a passage through which an eluant for eluting the target component captured in the concentration column is fed to the concentration column; a storage unit for storing the eluant; and a second passage-switching unit for switching between the state of forming a passage through which an analysis mobile phase is fed to the analysis column and a passage through which the eluant from the concentration column is fed to the storage unit, and the state of forming a passage through which analysis mobile phase is fed to the analysis column via the storage unit.Type: ApplicationFiled: December 15, 2014Publication date: November 30, 2017Applicant: SHIMADZU CORPORATIONInventors: Tairo OGURA, Mikael LEVI
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Patent number: 9799499Abstract: In a mass spectrometric method of the invention, a mass spectrometer (2) is used having a mass separation unit (231, 234) before and after a collision cell (232) for fragmenting ions. When a product ion corresponding to a precursor ion set for a sample is selected by performing product ion scan with respect to the precursor ion, an exclusion range of mass-to-charge ratios is set based on information on non-selection ions input by a user, and a product ion that satisfies a predefined criterion is selected within a range of mass-to-charge ratios excluding the exclusion range in a product ion spectrum. According to the mass spectrometric method of the invention, product ions suited for measurement on a target compound can be selected.Type: GrantFiled: November 28, 2013Date of Patent: October 24, 2017Assignee: SHIMADZU CORPORATIONInventors: Yuko Kobayashi, Tairo Ogura
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Patent number: 9638677Abstract: When setting analysis conditions, an analysis operator sets, on a dwell-time calculation/loop-time listing window, the target value of a loop time corresponding to the measurement-time interval to repeat an analysis for one ion, and clicks a dwell time calculation button. Then, a dwell time calculator computes the dwell time for each event, based on the target value of the loop time, the arrangement of events set at that point in time, the number of target ion species set in each event, and other conditional factors. The calculated result is displayed in a dwell time calculation result display field in a listing table. The largest and smallest values of the dwell time are displayed in the largest/smallest dwell time display field. The analysis operator checks this display and changes the target value of the loop time and/or the measurement time of the event so as to achieve an appropriate dwell time.Type: GrantFiled: August 26, 2013Date of Patent: May 2, 2017Assignee: SHIMADZU CORPORATIONInventors: Yuko Kobayashi, Hiroshi Sugawara, Tairo Ogura
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Publication number: 20170032947Abstract: In a mass spectrometric method of the invention, a mass spectrometer (2) is used having a mass separation unit (231, 234) before and after a collision cell (232) for fragmenting ions. When a product ion corresponding to a precursor ion set for a sample is selected by performing product ion scan with respect to the precursor ion, an exclusion range of mass-to-charge ratios is set based on information on non-selection ions input by a user, and a product ion that satisfies a predefined criterion is selected within a range of mass-to-charge ratios excluding the exclusion range in a product ion spectrum. According to the mass spectrometric method of the invention, product ions suited for measurement on a target compound can be selected.Type: ApplicationFiled: November 28, 2013Publication date: February 2, 2017Applicant: SHIMADZU CORPORATIONInventors: Yuko KOBAYASHI, Tairo OGURA
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Publication number: 20160209378Abstract: When setting analysis conditions, an analysis operator sets, on a dwell-time calculation/loop-time listing window, the target value of a loop time corresponding to the measurement-time interval to repeat an analysis for one ion, and clicks a dwell time calculation button. Then, a dwell time calculator computes the dwell time for each event, based on the target value of the loop time, the arrangement of events set at that point in time, the number of target ion species set in each event, and other conditional factors. The calculated result is displayed in a dwell time calculation result display field in a listing table. The largest and smallest values of the dwell time are displayed in the largest/smallest dwell time display field. The analysis operator checks this display and changes the target value of the loop time and/or the measurement time of the event so as to achieve an appropriate dwell time.Type: ApplicationFiled: August 26, 2013Publication date: July 21, 2016Applicant: SHIMADZU CORPORATIONInventors: Yuko KOBAYASHI, Hiroshi SUGAWARA, Tairo OGURA
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Publication number: 20160042929Abstract: A mass spectrometer including a memory unit storing information indicating combinations of precursor ions for CIDs in respective stages. If an MS1 spectrum on which CID is not performed is obtained during execution of an analysis, a precursor ion selector determines whether an ion registered as a precursor ion for the first-stage CID exists on the MS1 spectrum, based on the list held in the memory unit. If the ion exists, an MS2 analysis in which the ion is set as a precursor ion is immediately executed. Subsequently, the precursor ion selector determines whether or not an ion registered as a precursor ion for the second-stage CID in association with the precursor ion for the first-stage CID exists on an MS2 spectrum. If the ion exists, an MS3 analysis in which the ion is set as a precursor ion is immediately executed, so that an MS3 spectrum is acquired.Type: ApplicationFiled: March 26, 2013Publication date: February 11, 2016Applicant: SHIMADZU CORPORATIONInventor: Tairo OGURA