Abstract: An adhesive layer is formed by cross-linking an adhesive composition containing: a polyester resin that is a copolymer of a polycarboxylic acid and a polyalcohol; a cross-linking agent; and at least one cross-linking catalyst selected from the group consisting of an organic zirconium compound, an organic iron compound, and an organic aluminum compound, the adhesive layer having a gel fraction of 40% or more after being retained at a temperature of 85° C. and a relative humidity of 85% for 300 hours, and having a 180° peel adhesive strength of 100 mN/20 mm or more with respect to a PMMA film.

Abstract: On a straight advancing route in which a straight advancing vehicle speed is preset following a turning route in which a turning vehicle speed is preset, a traveling processor causes a combine to travel at a straight advancing vehicle speed if the distance of the straight advancing route is not less than a predetermined distance, and causes a combine to travel at a turning vehicle speed if the distance of the straight advancing route is less than the predetermined distance.

Abstract: A traveling processor causes a combine to perform an autonomous travel following a target route including a turning route in a field. An acquisition processor acquires a distance from a turning center point of the turning route to an edge of the field. A setting processor sets a speed of the combine on a turning route where the distance from the turning center point to the edge of the field is not more than a predetermined distance to a predetermined speed smaller than a speed of the combine on a turning route where the distance from the turning center point to the edge of the field exceeds the predetermined distance.

Abstract: The present disclosure relates to a microneedle array having a pin frog shape which is coated with a drug composition comprising a drug and an additive and having Vickers hardness of about 3 or more is applied to a microneedle array. The microneedle array coated with the drug composition according to the present invention can be used in the field in which the drug is required to be administered with high quantitative performance even when the drug is contained at low content.

Abstract: The present invention relates to a microneedle and a microneedle array. More specifically, it relates to a microneedle and a microneedle array capable of injecting a drug into the surface layer or horny layer of the skin easily, safely and efficiently.

Abstract: The present invention provides a microneedle array which makes it possible to quantitatively and accurately inject a drug into the skin. The present inventors have found that when a microneedle array is coated with a drug composition comprising a drug and an additive which has a Vickers hardness of about 3 or more, the removal of the drug can be avoided, and the drug can be surely inserted into the skin along with the microneedle array. As a result, the microneedle array coated with the drug composition of the present invention can be used in the fields in which the drug is required to be administrated with high quantitative performance even when the drug is contained in small amounts, e.g., the administration of a vaccine, and the scope of application of the microneedle array can be extended.

Abstract: The present invention relates to a microneedle and a microneedle array. More specifically, it relates to a microneedle and a microneedle array capable of injecting a drug into the surface layer or horny layer of the skin easily, safely and efficiently.

Abstract: A hydrogel composed of a polyanionic polysaccharide derivative having a hydrophobic group introduced by covalent bonding and a salt solution with a salt concentration of 50 mM or more and 200 mM or less, the hydrogel having an aggregate structure with an average particle diameter of 100 to 2000 nm in the diluted solution, as well as a method for manufacturing the hydrogel comprising the steps of preparing a mixture containing a polyanionic polysaccharide derivative having a hydrophobic group introduced and a salt solution with a salt concentration of 50 mM or more and 200 mM or less and subjecting the mixture to heat treatment. The hydrogel of the present invention has a long-term stability and may be filtered using a porous filter having a pore diameter of 5 ?m or more.

Abstract: A hydrogel comprising a polysaccharide, wherein amphiphilic side chains are bonded to the carboxyl groups of a polysaccharide with carboxyl groups on side chains, an inorganic ion other than calcium ion, and water, and a method for its preparation. The gel has high viscoelasticity, can be injected into the body using an instrument such as a syringe, and is useful for various biomedical materials.