Abstract: The present invention provides a method of producing a compound by a cross-coupling reaction, the method comprising: reacting compound 1 having a leaving group X1 on a carbon atom of an aromatic ring with compound 2 having a reactive group capable of a C—O bond formation reaction or a C—N bond formation reaction by substitution with the leaving group, in the presence of a catalyst and a base, in a solvent containing an amide-based solvent represented by formula A, wherein R1, R2, and R3 are each independently C1-4 alkyl provided that the sum of carbon atoms of R1, R2, and R3 is 4 or more and 6 or less, wherein X1 is a halogen atom or —O—SO2—R4.

Abstract: The present invention provides a method for producing an amide compound, comprising reacting a carboxylic acid compound and an amine compound in the presence of a condensing agent and a first base to obtain an amide compound, wherein the first base is a compound represented by formula A, and a molar ratio of the first base to the condensing agent (first base/condensing agent) is 1.8 or less.

Abstract: The present invention provides a library comprising 1×102 to 1×108 compounds, wherein the compounds have the following structure where a first core block (first CB), a first linker (first L), and a second core block (second CB) are covalently linked: (first CB)-(first L)-(second CB), wherein the library comprises two or more types of first CB, two or more types of first L, and two or more types of second CB, and the library is constituted by one or two or more mixtures comprising 1×102 to 1×105 of the compounds.

Abstract: Provided herein is a method for removing a tert-butoxycarbonyl (Boc) group in a compound having a Boc group on a nitrogen atom, comprising treating the compound with a trifluoromethanesulfonic acid metal salt (metal triflate: M(OTf)n) or rare-earth metal halide (MXn) in the presence of a base to obtain a compound in which the Boc group is converted to H—.

Abstract: A welding method for making cladding or buttering on an inner surface of a base material, an inner surface of an opening portion formed in the base material, and the cut surface formed in such a manner that the cut surface is continuous from the inner surface of the base material to the inner surface of the opening portion, wherein the welding method includes a step of forming a protruding portion on the base material in advance, the protruding portion including a temporary welding surface extending toward the center of the opening portion in such a manner that the temporary welding surface is uniformly continuous to the inner surface of the base material and including the cut surface buried therein.

Abstract: A welding method for making cladding or buttering on an inner surface of a base material, an inner surface of an opening portion formed in the base material, and the cut surface formed in such a manner that the cut surface is continuous from the inner surface of the base material to the inner surface of the opening portion, wherein the welding method includes a step of forming a protruding portion on the base material in advance, the protruding portion including a temporary welding surface extending toward the center of the opening portion in such a manner that the temporary welding surface is uniformly continuous to the inner surface of the base material and including the cut surface buried therein.

Abstract: A rotary positioning stage which enables a high speed and high precision positioning. The rotary positioning stage includes an arc-like portion 7a for forming an arc with respect to a rotation shaft 10, a rotary stage 2 on which a workpiece 5 can be mounted, a pulley 12 contacting the arc-like portion 7a, first positioning means 3 for positioning the workpiece 5 by rotating the rotary stage 2 via the pulley 12, second positioning means 4 for positioning the workpiece 5 by slightly moving the first positioning means 3 in a straight line-like manner in a tangent line direction at a contact point between the arc-like portion 7a and the pulley 12, wherein the straight line motion of the first positioning means 3 is converted into a rotational motion of the rotary stage 2 to position the workpiece 5.

Abstract: A rotary positioning stage which enables a high speed and high precision positioning. The rotary positioning stage includes an arc-like portion 7a for forming an arc with respect to a rotation shaft 10, a rotary stage 2 on which a workpiece 5 can be mounted, a pulley 12 contacting the arc-like portion 7a, first positioning means 3 for positioning the workpiece 5 by rotating the rotary stage 2 via the pulley 12, second positioning means 4 for positioning the workpiece 5 by slightly moving the first positioning means 3 in a straight line-like manner in a tangent line direction at a contact point between the arc-like portion 7a and the pulley 12, wherein the straight line motion of the first positioning means 3 is converted into a rotational motion of the rotary stage 2 to position the workpiece 5.

Abstract: In a tool failure detection apparatus for a working machine such as a drilling machine for circuit boards, light is irradiated onto a workable area of a workpiece, and reflection light from the workable area is picked up by an imaging unit to produce a video signal. A video signal indicative of at least either one of a tool image and a worked void image which is picked up within a predetermined region of a picture is sampled to calculate an image area. A comparator compares a calculated image area with a preset reference value indicative of normality of the tool to judge whether the tool is normal or broken.