Patents by Inventor Taizhi Wu

Taizhi Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salt derivative of tetrahydroisoquinoline and crystalline thereof and preparation method therefore and application thereof
    Patent number: 10676442
    Abstract: The present invention discloses a salt derivative of 1-(3-methanesulfonamidobenzyl)-6-methoxy-7-benzyloxy-1,2,3,4-tetrahydroisoquinoline. The salt derivative has a solubility in water of not less than 3.0 nmol/mL or 1.8 mg/mL. The salt derivative has a solubility in water of not less than 3.0 nmol/mL or 1.8 mg/mL.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: June 9, 2020
    Assignees: China State Institute of Pharmaceutical Industry, Shanghai Institute of Pharmaceutical Industry
    Inventors: Meihua Xie, Fuli Zhang, Taizhi Wu, Jialiang Zhong
  • SALT DERIVATIVE OF TETRAHYDROISOQUINOLINE AND CRYSTALLINE THEREOF AND PREPARATION METHOD THEREFORE AND APPLICATION THEREOF
    Publication number: 20190177277
    Abstract: The present invention discloses a salt derivative of 1-(3-methanesulfonamidobenzyl)-6-methoxy-7-benzyloxy-1,2,3,4-tetrahydroisoquinoline. The salt derivative has a solubility in water of not less than 3.0 nmol/mL or 1.8 mg/mL. The salt derivative has a solubility in water of not less than 3.0 nmol/mL or 1.8 mg/mL.
    Type: Application
    Filed: August 30, 2017
    Publication date: June 13, 2019
    Inventors: Meihua XIE, Fuli ZHANG, Taizhi WU, Jialiang ZHONG
  • Process for the preparation of 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylates
    Patent number: 8618308
    Abstract: The present invention discloses a process for obtaining 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate by the reaction of 4,4-dimethyl-2-propyl-4,6-dihydrofuro[3,4-d]imidazole, or its hydrolysis product, or its ring-opening product, with alcohol under appropriate catalytic conditions. Furthermore, the present invention also provides a process for obtaining high purity 4,4-dimethyl-2-propyl-4,6-dihydrofuro[3,4-d]imidazole.
    Type: Grant
    Filed: November 17, 2008
    Date of Patent: December 31, 2013
    Assignee: Shanghai Institute of Pharmaceutical Industry
    Inventors: Fuli Zhang, Taizhi Wu, Meihua Xie
  • Process for the Preparation of 4-(1-Hydroxy-1-Methylethyl)-2-Propyl-Imidazole-5-Carboxylates
    Publication number: 20120095237
    Abstract: The present invention discloses a process for obtaining 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate (formula I) by the reaction of 4,4-dimethyl-2-propyl-4,6-dihydrofuro[3,4-d]imidazole (formula II), or its hydrolysis product, or its ring-opening product, with alcohol under appropriate catalytic conditions. Furthermore, the present invention also provides a process for obtaining high purity 4,4-dimethyl-2-propyl-4,6-dihydrofuro[3,4-d]imidazole (formula II), therefore purified compound of formula I can be produced. Producing of olmesartan medoxomil at high purity is assured by said processes. R in formula I is selected from C1-C6 alkyl.
    Type: Application
    Filed: November 17, 2008
    Publication date: April 19, 2012
    Applicant: Shanghai Institute of Pharmaceutical Industry
    Inventors: Fuli Zhang, Taizhi Wu, Meihua Xie