Patents by Inventor Tajayuki Imamura

Tajayuki Imamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing human thrombin by gene modification technique
    Patent number: 7635577
    Abstract: A genetic recombinant human thrombin is provided. Human thrombin is efficiently prepared by the genetic engineering technique comprising the steps: (1) culturing a transfectant animal cell transfected with an expression vector in which a gene encoding human prethrombin is incorporated to the downstream of a promoter so as to produce and accumulate prethrombin in culture supernatant and recovering the produced human prethrombin; (2) treating a solution containing human prethrombin recovered in step (1) with ecarin so as to convert human prethrombin into human thrombin; and (3) purifying the solution obtained after the above activation process to obtain purified human thrombin. The present invention allows for provision of human thrombin in a large scale in a safe and economical manner due to exclusion of blood-derived components.
    Type: Grant
    Filed: July 4, 2002
    Date of Patent: December 22, 2009
    Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
    Inventors: Hiroshi Yonemura, Tajayuki Imamura, Hiroshi Nakatake, Kenji Soejima, Chikateru Nozaki