Patents by Inventor Tak W. Mak

Tak W. Mak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination therapies for inhibition of TTK protein kinase
    Patent number: 11766437
    Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: September 26, 2023
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Mark Robert Bray, Jacqueline M. Mason, Tak W. Mak, Graham Fletcher
  • Methods and compositions for modulating toso activity
    Patent number: 10822388
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: November 3, 2020
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • COMBINATION THERAPIES FOR INHIBITION OF TTK PROTEIN KINASE
    Publication number: 20200230144
    Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.
    Type: Application
    Filed: August 1, 2018
    Publication date: July 23, 2020
    Inventors: Mark Robert Bray, Jacqueline M. Mason, Tak W. Mak, Graham Fletcher
  • Methods and compositions for detection of targets for autoimmune disease
    Patent number: 10533222
    Abstract: The present invention is directed to methods and compositions for identifying targets for induction of self-tolerance and treatment of autoimmune disease.
    Type: Grant
    Filed: March 7, 2015
    Date of Patent: January 14, 2020
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Brian Hershenfield, Tak W. Mak
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20180016320
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: May 1, 2017
    Publication date: January 18, 2018
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Methods and compositions for modulating toso activity
    Patent number: 9670265
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: June 6, 2017
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Methods and compositions for modulating Toso activity
    Patent number: 9624289
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: April 18, 2017
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Antibodies to Toso
    Patent number: 9493561
    Abstract: The present invention provides methods and compositions for modulating Toso activity and treating diseases and disorders in which Toso is implicated. Such methods and compositions include the use of one or more antibodies that bind to a Toso protein or to a ligand of a Toso protein.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: November 15, 2016
    Assignee: University Health Network
    Inventors: Tak W. Mak, Xiuqiu Lai, Michael W. Tusche
  • Methods and compositions for modulating Toso activity
    Patent number: 9321824
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: April 26, 2016
    Assignee: Universal Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Methods and compositions for modulating Toso activity
    Patent number: 9228006
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 5, 2016
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • METHODS AND COMPOSITIONS FOR DETECTION OF TARGETS FOR AUTOIMMUNE DISEASE
    Publication number: 20150315642
    Abstract: The present invention is directed to methods and compositions for identifying targets for induction of self-tolerance and treatment of autoimmune disease.
    Type: Application
    Filed: March 7, 2015
    Publication date: November 5, 2015
    Inventors: Brian Hershenfield, Tak W. Mak
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20150299292
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: November 12, 2014
    Publication date: October 22, 2015
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • METHODS AND COMPOSITIONS FOR DETECTION OF TARGETS INVOLVED IN CANCER METASTASIS
    Publication number: 20150252434
    Abstract: The present invention is further directed to methods and compositions for identifying target nucleic acids that are involved in cancer metastasis.
    Type: Application
    Filed: March 6, 2015
    Publication date: September 10, 2015
    Inventors: Heiko Blaser, Tak W. Mak
  • METHODS AND COMPOSITIONS FOR MODIFYING THE IMMUNE RESPONSE
    Publication number: 20150250853
    Abstract: The present invention is directed to methods and compositions for modulating proteins involved in the immune response. The present invention further provides methods and compositions for treatment of autoimmune disease and cancer by modulating the expression and activity of such proteins.
    Type: Application
    Filed: March 6, 2015
    Publication date: September 10, 2015
    Inventor: Tak W. Mak
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20150197551
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: November 12, 2014
    Publication date: July 16, 2015
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20150139995
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 21, 2015
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • ANTIBODIES TO TOSO
    Publication number: 20150010542
    Abstract: The present invention provides methods and compositions for modulating Toso activity and treating diseases and disorders in which Toso is implicated. Such methods and compositions include the use of one or more antibodies that bind to a Toso protein or to a ligand of a Toso protein.
    Type: Application
    Filed: July 2, 2014
    Publication date: January 8, 2015
    Inventors: Tak W. Mak, Xiuqiu Lai, Michael W. Tusche
  • Novel Polypeptides Involved in Immune Response
    Publication number: 20140004129
    Abstract: Polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding the polypeptides, and vectors and host cells for expressing the polypeptides are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
    Type: Application
    Filed: October 2, 2012
    Publication date: January 2, 2014
    Applicants: AMGEN CANADA INC., AMGEN INC.
    Inventors: Steven K Yoshinaga, Tak W. Mak, Arda Shahinian, Anna Trafuri Bladt, Giorgio Senaldi
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20130281356
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 24, 2013
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Polypeptides involved in immune response
    Patent number: 8309083
    Abstract: Polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding the polypeptides, and vectors and host cells for expressing the polypeptides are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: November 13, 2012
    Assignees: Amgen, Inc., Amgen Canada Inc.
    Inventors: Steven K. Yoshinaga, Tak W. Mak, Arda Shahinian, Anna Tafuri Bladt, Giorgio Senaldi