Patents by Inventor Takaaki Araki
Takaaki Araki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8252781Abstract: [Object] It is to provide a novel compound useful for preventing and/or treating diseases that involves 11?-hydroxysteroid dehydrogenase 1 (in particular diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome). [Means to Solve the Object] A 1,2-diazetidin-3-one derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: GrantFiled: October 28, 2009Date of Patent: August 28, 2012Assignee: Kowa Company, Ltd.Inventors: Hisashi Nakashima, Takaaki Araki, Takahisa Ogamino, Noriaki Gomi, Yasushi Kaneko, Kazutoyo Abe, Tadaaki Ohgiya
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Patent number: 8236789Abstract: It is to provide a novel compound useful for preventing and/or treating diseases that involves 11?-hydroxysteroid dehydrogenase 1, particularly diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. It is an 1-adamantyl azetidin-2-one derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: GrantFiled: August 28, 2009Date of Patent: August 7, 2012Assignee: Kowa Company, Ltd.Inventors: Hisashi Nakashima, Takahiro Mori, Ryoko Mori, legal representative, Takaaki Araki, Takahisa Ogamino, Kazutoyo Abe, Tadaaki Ohgiya
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Publication number: 20120122906Abstract: Disclosed is a novel compound which has both angiotensin II receptor antagonist activity and PPAR? activating activity, and is useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, angina pectoris, cerebrovascular disorders, cerebral circulatory disorders, ischemic peripheral circulatory disorders, kidney diseases, arteriosclerosis, inflammatory diseases, type 2 diabetes, diabetic complication, insulin resistant syndrome, syndrome X, metabolic syndrome and hyperinsulinemia. Also disclosed is a pharmaceutical composition which contains the novel compound. Specifically disclosed are: a sulfonamide derivative represented by general formula (I), a salt thereof, or a solvate of the derivative or salt; and a pharmaceutical composition which contains the sulfonamide derivative, a salt thereof, or a solvate of the derivative or salt.Type: ApplicationFiled: August 27, 2010Publication date: May 17, 2012Applicant: KOWA COMPANY, LTD.Inventors: Toru Miura, Kazuhiro Onogi, Noriaki Gomi, Takaaki Araki, Junya Tagashira, Ryohei Sekimoto, Rio Ishida, Hitomi Aoki, Tadaaki Ohgiya
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Patent number: 7790903Abstract: A process for obtaining a compound (1) and an intermediate thereof in high yield and high optical yield is provided. A process for producing a compound (4), the process including reacting a compound (2) with a compound (3) in the presence of a base; and a process for producing a compound (1), the process including reacting a compound (2) with a compound (3) in the presence of a base to yield a compound (4) and then deesterifying the compound (4). wherein R represents an alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 8 carbon atoms.Type: GrantFiled: February 23, 2006Date of Patent: September 7, 2010Assignee: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Takaaki Araki, Minoru Koura, Kimiyuki Shibuya
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Publication number: 20100144694Abstract: [Object] It is to provide a novel compound useful for preventing and/or treating diseases that involves 11?-hydroxysteroid dehydrogenase 1 (in particular diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome). [Means to Solve the Object] A 1,2-diazetidin-3-one derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: ApplicationFiled: October 28, 2009Publication date: June 10, 2010Applicant: KOWA COMPANY, LTD.Inventors: Hisashi Nakashima, Takaaki Araki, Takahisa Ogamino, Noriaki Gomi, Yasushi Kaneko, Kazutoyo Abe, Tadaaki Ohgiya
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Patent number: 7714141Abstract: The invention provides a process for producing an optically active butyric acid compound and a production intermediate therefore at high yield and high purity. The present invention provides a process for producing Compound (6), including reacting Compound (1) with optically active 2-trifluoromethanesulfonyloxybutyrolactone (2a) in the presence of a base or reacting optically active 2-hydroxybutyrolactone (2b) under Mitsunobu reaction conditions, to thereby form Compound (3); reacting Compound (3) with an alcohol and a halogenating agent, to thereby form Compound (4); dehalogenating Compound (4), to thereby form Compound (5); and de-esterifying Compound (5).Type: GrantFiled: May 30, 2006Date of Patent: May 11, 2010Assignee: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Takaaki Araki, Minoru Koura, Kimiyuki Shibuya
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Publication number: 20100075943Abstract: It is to provide a novel compound useful for preventing and/or treating diseases that involves 11?-hydroxysteroid dehydrogenase 1, particularly diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. It is an 1-adamantyl azetidin-2-one derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: ApplicationFiled: August 28, 2009Publication date: March 25, 2010Applicant: KOWA COMPANY, LTD.,Inventors: Hisashi Nakashima, Takahiro Mori, Takaaki Araki, Takahisa Ogamino, Kazutoyo Abe, Tadaaki Ohgiya, Ryoko Mori
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Publication number: 20100022572Abstract: It is to provide a novel compound useful for preventing and/or treating diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. A spiro compound represented by the following general formula (1) or salt thereof, or their solvate.Type: ApplicationFiled: July 16, 2009Publication date: January 28, 2010Applicant: KOWA COMPANY, LTD.Inventors: Hisashi Nakashima, Takahisa Ogamino, Takaaki Araki, Noriaki Gomi, Yasushi Kaneko, Kazutoyo Abe, Tadaaki Ohgiya, Kimiyuki Shibuya
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Patent number: 7582791Abstract: A process for producing an optically active 2-hydroxybutyric ester (1), characterized by including reacting an optically active 2,3-epoxybutyric ester (2) with a thiol in the presence of scandium trifluoromethanesulfonate or ytterbium trifluoromethanesulfonate, to thereby produce Compound (3), and subjecting Compound (3) to desulfurization reaction: (wherein R represents a C1 to C6 alkyl group or a C7 or C8 aralkyl group; R1 represents a C1 to C12 alkyl group or a phenyl group; and * represents S- or R-absolute configuration). The present invention provides a process for producing an optically active 2-hydroxybutyric ester at high yield and high optical purity.Type: GrantFiled: August 24, 2006Date of Patent: September 1, 2009Assignee: Kowa Co., Ltd.Inventors: Takaaki Araki, Yukiyoshi Yamazaki, Kimiyuki Shibuya
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Patent number: 7538242Abstract: The present invention provides a production intermediate for compound (A-1) and a method for producing the intermediate at high yield and high optical yield.Type: GrantFiled: February 28, 2006Date of Patent: May 26, 2009Assignee: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Takaaki Araki, Minoru Koura, Kimiyuki Shibuya
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Publication number: 20090118535Abstract: A process for producing an optically active 2-hydroxybutyric ester (1), characterized by including reacting an optically active 2,3-epoxybutyric ester (2) with a thiol in the presence of scandium trifluoromethanesulfonate or ytterbium trifluoromethanesulfonate, to thereby produce Compound (3), and subjecting Compound (3) to desulfurization reaction: (wherein R represents a C1 to C6 alkyl group or a C7 or C8 aralkyl group; R1 represents a C1 to C12 alkyl group or a phenyl group; and * represents S- or R-absolute configuration). The present invention provides a process for producing an optically active 2-hydroxybutyric ester at high yield and high optical purity.Type: ApplicationFiled: August 24, 2006Publication date: May 7, 2009Inventors: Takaaki Araki, Yukiyoshi Yamazaki, Kimiyuki Shibuya
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Publication number: 20090076280Abstract: The invention provides a process for producing an optically active butyric acid compound and a production intermediate therefor at high yield and high purity. The present invention provides a process for producing Compound (6), including reacting Compound (1) with optically active 2-trifluoromethanesulfonyloxybutyrolactone (2a) in the presence of a base or reacting optically active 2-hydroxybutyrolactone (2b) under Mitsunobu reaction conditions, to thereby form Compound (3); reacting Compound (3) with an alcohol and a halogenating agent, to thereby form Compound (4); dehalogenating Compound (4), to thereby form Compound (5); and de-esterifying Compound (5).Type: ApplicationFiled: May 30, 2006Publication date: March 19, 2009Applicant: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Takaaki Araki, Minoru Koura, Kimiyuki Shibuya
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Publication number: 20090023944Abstract: The present invention provides a production intermediate for compound (A-1) and a method for producing the intermediate at high yield and high optical yield. The present invention provides a method for producing compound (3) characterized in that compound (1) is reacted with compound (2) in the presence of a base. (wherein R represents a C1 to C6 alkyl group or a C7 to C8 aralkyl group).Type: ApplicationFiled: February 28, 2006Publication date: January 22, 2009Applicant: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Takaaki Araki, Minoru Koura, Kimiyuki Shibuya
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Publication number: 20080306102Abstract: A Spiro oxindole compound represented by formula (1) of the present invention or salt thereof, or their solvate shows a superior inhibitory effect of 11?-hydroxysteroid dehydrogenasel, and is useful as an agent for preventing or treating a disease that involves 11?-hydroxysteroid dehydrogenasel (in particular, diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome).Type: ApplicationFiled: May 16, 2008Publication date: December 11, 2008Applicant: KOWA CO., LTD.Inventors: Hisashi NAKASHIMA, Takaaki ARAKI, Takahisa OGAMINO, Yasushi KANEKO, Kazutoyo ABE, Kimiyuki SHIBUYA, Tadaaki OHGIYA
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Publication number: 20080194833Abstract: A process for obtaining a compound (1) and an intermediate thereof in high yield and high optical yield is provided. A process for producing a compound (4), the process including reacting a compound (2) with a compound (3) in the presence of a base; and a process for producing a compound (1), the process including reacting a compound (2) with a compound (3) in the presence of a base to yield a compound (4) and then deesterifying the compound (4). wherein R represents an alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 8 carbon atoms.Type: ApplicationFiled: February 23, 2006Publication date: August 14, 2008Applicant: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Takaaki Araki, Minoru Koura, Kimiyuki Shibuya
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Patent number: 7183295Abstract: A compound represented by the following formula (1): (wherein each of R1 and R2, which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R3a, R3b, R4a, and R4b, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N—R5 (R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(O)l (l is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, or an aminosuType: GrantFiled: April 20, 2006Date of Patent: February 27, 2007Assignee: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Kazutoyo Abe, Soichi Oda
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Patent number: 7109226Abstract: A compound represented by the following formula (1): Or a salt thereof; and therapeutic durgs containing the compound. The compound selectively activates PPAR?.Type: GrantFiled: September 3, 2004Date of Patent: September 19, 2006Assignee: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Kazutoyo Abe, Soichi Oda
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Publication number: 20060189667Abstract: A compound represented by the following formula (1): (wherein each of R1 and R2, which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R3a, R3b, R4a, and R4b, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N—R5 (R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(O)l (l is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, or an aminosType: ApplicationFiled: April 20, 2006Publication date: August 24, 2006Applicant: KOWA CO., LTD.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Kazutoyo Abe, Soichi Oda
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Publication number: 20050101636Abstract: A compound represented by the following formula (1): Or a salt thereof; and therapeutic durgs containing the compound. The compound selectively activates PPAR?.Type: ApplicationFiled: September 3, 2004Publication date: May 12, 2005Applicant: KOWA CO., LTD.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Kazutoyo Abe, Soichi Oda
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Patent number: 5145775Abstract: A polyhedrin gene of Spodoptera litura nuclear polyhedrosis virus (SlNPV C-411) has the following restriction enzyme cleavage map and about 3 kilobase pairs: ##STR1## At least a part of said polyhedrin gene can be substituted by a gene coding for a useful substance to construct a vector and a recombinant virus, and it is possible to produce a useful substance such as a peptide, protein or glycoprotein by culturing a cell infected with the recombinant virus.Type: GrantFiled: February 23, 1990Date of Patent: September 8, 1992Assignee: Research Association for Biotechnology of Agricultural ChemicalsInventors: Nobutoshi Yamada, Norifusa Matsuo, Takaaki Araki