Patents by Inventor Takaaki HIROTSU
Takaaki HIROTSU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12019068Abstract: The present invention provides a method for predicting a therapeutic effect and/or monitoring recurrence in a cancer patient. Disclosed is a method for detecting a therapeutic effect of cancer treatment in a cancer patient, comprising: measuring nematode tactic behavior to each of pre-treatment urine and in-treatment or post-treatment urine from the cancer patient; and comparing a result of measuring the tactic behavior to the pre-treatment urine and a result of measuring the tactic behavior to the in-treatment or post-treatment urine, wherein when attraction is weakened or avoidance is strengthened after the treatment, it is determined that the therapeutic effect is detected.Type: GrantFiled: March 30, 2018Date of Patent: June 25, 2024Assignees: HIROTSU BIO SCIENCE INC., NANPUH HOSPITALInventor: Takaaki Hirotsu
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Publication number: 20230408496Abstract: The present invention provides a method for analyzing a blood sample. According to the present invention, there is provided, for example, a method for testing or analyzing a blood sample from a subject having cancer or suspected of having cancer, including evaluating taxis behavior of nematodes to the blood sample. According to the present invention, there is provided, for example, a method for evaluating whether a subject has cancer or not by the above method.Type: ApplicationFiled: November 16, 2021Publication date: December 21, 2023Applicant: Hirotsu Bio Science Inc.Inventor: Takaaki HIROTSU
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Patent number: 11725226Abstract: The present invention provides a method for highly sensitively and highly specifically detecting a kidney cancer. According to the present invention, there is provided, for example, a method for detecting a kidney cancer in a subject, comprising diluting a urine sample obtained from the subject at a predetermined ratio, and determining whether or not nematodes exhibit attraction behavior toward the diluted urine sample, wherein the predetermined ratio is 200 or more.Type: GrantFiled: August 20, 2018Date of Patent: August 15, 2023Assignees: HIROTSU BIO SCIENCE INC., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Takaaki Hirotsu, Hirofumi Jono
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Patent number: 11719698Abstract: A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.Type: GrantFiled: December 10, 2014Date of Patent: August 8, 2023Assignee: HIROTSU BIO SCIENCE INC.Inventors: Takaaki Hirotsu, Hideto Sonoda
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Publication number: 20230204590Abstract: A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.Type: ApplicationFiled: March 9, 2023Publication date: June 29, 2023Applicant: HIROTSU BIO SCIENCE INC.Inventors: Takaaki HIROTSU, Hideto SONODA
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Publication number: 20230084843Abstract: To provide a research result distribution platform that is highly convenient for researchers and people trying to use research results. A research result acquisition unit acquires research result information indicating results of research of researchers. A management unit manages one or more pieces of research result information acquired by the research result acquisition unit, for each researcher. An extraction unit extracts the research result information desired by a user from the one or more pieces of research result information managed by the management unit. A research result presentation unit presents the research result information extracted by the extraction unit to the user. The problem is solved thereby. For both researchers and users, gaining and losing of service points to make the research result distribution platform more active is controlled.Type: ApplicationFiled: November 17, 2022Publication date: March 16, 2023Inventors: Takaaki HIROTSU, Naoki SAKAKIBARA
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Patent number: 11479800Abstract: The present invention provides a method for detecting cancer using a tissue specimen. Specifically, for example, there is provided a method for detecting cancer in an organ or tissue having cancer, comprising: preparing a cell lysate from a region suspected to be cancer isolated from the organ or tissue; and evaluating a tactic behavior of a nematode for the cell lysate.Type: GrantFiled: July 10, 2018Date of Patent: October 25, 2022Assignees: HIROTSU BIO SCIENCE INC., NANPUH HOSPITALInventors: Takaaki Hirotsu, Takuma Yoshinaga
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Publication number: 20220147939Abstract: To provide a research result distribution platform that is highly convenient for researchers and people trying to use research results. A research result acquisition unit 111 acquires research result information indicating results of research of researchers R. A management unit 102 manages one or more pieces of research result information acquired by the research result acquisition unit 111, for each researcher R. An extraction unit 103 extracts the research result information desired by a user U from the one or more pieces of research result information managed by the management unit 102. A research result presentation unit 141 presents the research result information extracted by the extraction unit 103 to the user U. The problem is solved thereby.Type: ApplicationFiled: May 28, 2020Publication date: May 12, 2022Inventors: Takaaki HIROTSU, Naoki SAKAKIBARA
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Publication number: 20210356470Abstract: A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.Type: ApplicationFiled: April 27, 2021Publication date: November 18, 2021Applicant: HIROTSU BIO SCIENCE INC.Inventors: Takaaki HIROTSU, Hideto SONODA
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Patent number: 11150234Abstract: The present invention provides a method for evaluating the taxic behavior of nematodes in response to an odor substance based on olfactory sense, and a dish and a behavior evaluation system to be used for the evaluation method. [Solution] Provided is a method for evaluating the taxic behavior of nematodes in response to odor of a test sample, the method including: a) providing a dish in which the test sample is arranged on the bottom surface, and nematodes are arranged in a region or a site of the bottom surface 1 cm to 3 cm away from the test sample; b) observing the arrangement of the nematodes on the bottom surface at 3 to 15 minutes after the later one of the test sample or the nematodes is arranged; and c) evaluating whether the nematodes show attraction behavior or avoidance behavior in response to the test sample, from the arrangement of the nematodes observed, and a dish or a taxic behavior evaluation system suitable for the method.Type: GrantFiled: September 11, 2017Date of Patent: October 19, 2021Assignee: HIROTSU BIO SCIENCE INC.Inventors: Takaaki Hirotsu, Takayuki Uozumi, Satoru Kaifuchi
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Publication number: 20210215669Abstract: A method of examining for cancer in a non-primate mammal such as a pet animal may include, for example, a method of examining or diagnosing for cancer in a non-primate mammal, including evaluating taxic behavior of nematodes toward a urine sample from a subject mammal.Type: ApplicationFiled: August 14, 2019Publication date: July 15, 2021Applicant: Hirotsu Bio Science Inc.Inventors: Takaaki HIROTSU, Satoru KAIFUCHI, Toshimi SUGIMOTO, Hideshi ISHII, Masamitsu KONNO, Yuji UEDA, Shogo KOBAYASHI, Hidetoshi EGUCHI, Yuichiro DOKI, Masaki MORI
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Publication number: 20200400653Abstract: The present invention provides a method for predicting a therapeutic effect and/or monitoring recurrence in a cancer patient. Disclosed is a method for detecting a therapeutic effect of cancer treatment in a cancer patient, comprising: measuring nematode tactic behavior to each of pre-treatment urine and in-treatment or post-treatment urine from the cancer patient; and comparing a result of measuring the tactic behavior to the pre-treatment urine and a result of measuring the tactic behavior to the in-treatment or post-treatment urine, wherein when attraction is weakened or avoidance is strengthened after the treatment, it is determined that the therapeutic effect is detected.Type: ApplicationFiled: March 30, 2018Publication date: December 24, 2020Applicants: HIROTSU BIO SCIENCE INC., NANPUH HOSPITALInventor: Takaaki HIROTSU
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Publication number: 20200208192Abstract: The present invention provides a method for highly sensitively and highly specifically detecting a kidney cancer. According to the present invention, there is provided, for example, a method for detecting a kidney cancer in a subject, comprising diluting a urine sample obtained from the subject at a predetermined ratio, and determining whether or not nematodes exhibit attraction behavior toward the diluted urine sample, wherein the predetermined ratio is 200 or more.Type: ApplicationFiled: August 20, 2018Publication date: July 2, 2020Applicants: HIROTSU BIO SCIENCE INC., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Takaaki HIROTSU, Hirofumi JONO
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Publication number: 20200165655Abstract: The present invention provides a method for detecting cancer using a tissue specimen. Specifically, for example, there is provided a method for detecting cancer in an organ or tissue having cancer, comprising: preparing a cell lysate from a region suspected to be cancer isolated from the organ or tissue; and evaluating a tactic behavior of a nematode for the cell lysate.Type: ApplicationFiled: July 10, 2018Publication date: May 28, 2020Applicants: HIROTSU BIO SCIENCE INC., NANPUH HOSPITALInventors: Takaaki HIROTSU, Takuma YOSHINAGA
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Publication number: 20190369084Abstract: The present invention provides a method for evaluating the taxic behavior of nematodes in response to an odor substance based on olfactory sense, and a dish and a behavior evaluation system to be used for the evaluation method. [Solution] Provided is a method for evaluating the taxic behavior of nematodes in response to odor of a test sample, the method including: a) providing a dish in which the test sample is arranged on the bottom surface, and nematodes are arranged in a region or a site of the bottom surface 1 cm to 3 cm away from the test sample; b) observing the arrangement of the nematodes on the bottom surface at 3 to 15 minutes after the later one of the test sample or the nematodes is arranged; and c) evaluating whether the nematodes show attraction behavior or avoidance behavior in response to the test sample, from the arrangement of the nematodes observed, and a dish or a taxic behavior evaluation system suitable for the method.Type: ApplicationFiled: September 11, 2017Publication date: December 5, 2019Applicant: HIROTSU BIO SCIENCE INC.Inventors: Takaaki HIROTSU, Takayuki UOZUMI, Satoru KAIFUCHI
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Publication number: 20170016906Abstract: A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.Type: ApplicationFiled: December 10, 2014Publication date: January 19, 2017Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATIONInventors: Takaaki HIROTSU, Hideto SONODA