Abstract: There is provided a medicine management system in which, in order to prevent a medicine known as the one which may cause a serious side effect when a certain patient takes it from being transferred to the certain patient, it is judged whether or not information from the prescribing doctor, the patient, and the pharmacist all registered in the system respectively satisfies a transfer condition, the result is notified, and records can be preserved for individual information providers not by telephone and IVRs.

Abstract: A class of novenl compounds represented by the formula (I) ##STR1## wherein R.sub.1 s are the same or different groups and each represents hydrogen atom or alkyl group having 1 to 4 carbon atoms; R.sub.2 is phenyl group, naphthyl group, or either phenyl or naphthyl substituted with at least one hydroxyl, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms; R.sub.3 is hydrogen atom, alkyl group having 1 to 4 carbon atoms or CH.sub.2 COOR.sub.4 group, in which R.sub.4 is hydrogen atom or alkyl group having 1 to 12 carbon atoms; n is 0 or 1, the configuration of 5-methylene group includes both E-isomer and Z-isomer, providing excepting the case wherein R.sub.1 is hydrogen or methyl, R.sub.2 is 3,5-di-t-butyl-4-hydroxyphenyl, R.sub.3 is hydrogen and n is 0 or pharmacologically acceptable salts thereof when R.sub.3 or R.sub.4 is hydrogen atomThe invention also concerns preparation methods thereof.