Patents by Inventor Takaaki Shiyama

Takaaki Shiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Affinity resin
    Patent number: 8778613
    Abstract: A resin which is prepared by polymerizing a monomer component incorporating a hydrophilic spacer, and a ligand-immobilized solid phase carrier obtained by immobilizing a ligand to the resin, are capable of reducing the non-specific adsorption of substances, other than the target molecule for the ligand, which mingle in the sample, to the resin and/or the ligand. Therefore, target molecule search, identification and the like with less noise are enabled.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: July 15, 2014
    Assignee: Reverse Proteomics Research Institute Co., Ltd.
    Inventors: Akito Tanaka, Takaaki Shiyama, Akira Yamazaki
  • Method of inhibiting nonspecific interaction between molecules on solid phase support
    Patent number: 7919653
    Abstract: The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: April 5, 2011
    Assignees: Reverse Proteomics Research Institute Co., Ltd., Astellas Pharma Inc.
    Inventors: Akito Tanaka, Tomohiro Terada, Tsuruki Tamura, Takaaki Shiyama, Akira Yamazaki, Minoru Furuya, Masayuki Haramura
  • Method for Suppressing Intermolecular Nonspecific Interaction and for Intensifying Intermolecular Specific Interaction on Metal Surface
    Publication number: 20080176341
    Abstract: The present invention provides a method of searching for a target molecule for a ligand immobilized on a metal surface or analyzing the interaction between a ligand and a target molecule, characterized in that the immobilization of the ligand on the metal surface via a hydrophilic spacers, and the method eliminates or suppresses a nonspecific interaction that prevents analysis of intermolecular interaction on a metal surface, and can intensify specific intermolecular interactions.
    Type: Application
    Filed: August 19, 2004
    Publication date: July 24, 2008
    Applicant: Reverse Protemics Research Institute Co., Ltd.
    Inventors: Akito Tanaka, Tomohiro Terada, Tsuruki Tamura, Takaaki Shiyama, Akira Yamazaki, Minoru Furuya, Masayuki Haramura
  • Affinity resin
    Publication number: 20070167594
    Abstract: A resin which is prepared by polymerizing a monomer component incorporating a hydrophilic spacer, and a ligand-immobilized solid phase carrier obtained by immobilizing a ligand to the resin, are capable of reducing the non-specific adsorption of substances, other than the target molecule for the ligand, which mingle in the sample, to the resin and/or the ligand. Therefore, target molecule search, identification and the like with less noise are enabled.
    Type: Application
    Filed: October 15, 2004
    Publication date: July 19, 2007
    Applicant: REVERSE PROTEOMICS RESEARCH INSTITUTE CO., LTD
    Inventors: Akito Tanaka, Takaaki Shiyama, Akira Yamazaki
  • Method of inhibiting nonspecific interaction between molecules on solid phase support
    Publication number: 20060177943
    Abstract: The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.
    Type: Application
    Filed: July 30, 2003
    Publication date: August 10, 2006
    Applicants: Reverse Proteomics Research Institute Co., Ltd., Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Akito Tanaka, Tomohiro Terada, Tsuruki Tamura, Takaaki Shiyama, Akira Yamazaki, Minoru Furuya, Masayuki Haramura