Abstract: The present invention provides a method of screening for a compound that enhances or inhibits the transport activity of OATP1B1, using dichlorofluorescein. The present invention also provides a use of dichlorofluorescein in measurement of the expression level of OATP1B1. The present invention further provides a method for measuring the expression level of OATP1B1 in test cells, using dichlorofluorescein. The present invention further provides a use of a kit including dichlorofluorescein and positive cells expressing OATP1B1 in measurement of the expression level of OATP1B1 in test cells.

Abstract: The present invention provides a method of screening for a compound that enhances or inhibits the transport activity of OATP1B1, using dichlorofluorescein. The present invention also provides a use of dichlorofluorescein in measurement of the expression level of OATP1B1. The present invention further provides a method for measuring the expression level of OATP1B1 in test cells, using dichlorofluorescein. The present invention further provides a use of a kit including dichlorofluorescein and positive cells expressing OATP1B1 in measurement of the expression level of OATP1B1 in test cells.

Abstract: A vehicle body slip angle-estimating device which, in estimating a vehicle body slip angle with an algorithm using a nonlinear model, is capable of accurately estimating a vehicle body slip angle irrespective of whether the frequency of occurrence of a state during traveling of the vehicle. A basic value-calculating section calculates a basic value of a vehicle body slip angle with an algorithm using a neural network model. A turning state-determining section determines whether the vehicle is in a predetermined limit turning traveling state. A correction value-calculating section calculates a correction value with an algorithm using a predetermined linear model when the vehicle is in the predetermined state. In the other cases, the correction value is set to 0. A straight traveling-determining section sets the angle to the sum of the basic value and the correction value when the vehicle is in a turning traveling state.

Abstract: An ignition timing control system for an internal combustion engine, which is capable of properly carrying out ignition timing control over a wide control range, thereby making it possible to improve fuel economy, and is capable of suppressing combustion fluctuation, thereby making it possible to improve drivability. Ignition timing is calculated, when the engine is determined to be in an intense combustion mode, such that a largest in-cylinder pressure angle at which in-cylinder pressure becomes largest converges to a target angle, whereas when the engine is determined to be in a weak combustion mode, the same is calculated by feedback, based on the target angle and combustion state parameters indicative of a combustion state in the cylinder.

Abstract: An ignition timing control system for an internal combustion engine, which is capable of properly carrying out ignition timing control over a wide control range, thereby making it possible to improve fuel economy, and is capable of suppressing combustion fluctuation, thereby making it possible to improve drivability. Ignition timing is calculated, when the engine is determined to be in an intense combustion mode, such that a largest in-cylinder pressure angle at which in-cylinder pressure becomes largest converges to a target angle, whereas when the engine is determined to be in a weak combustion mode, the same is calculated by feedback, based on the target angle and combustion state parameters indicative of a combustion state in the cylinder.

Abstract: A vehicle body slip angle-estimating device which, in estimating a vehicle body slip angle with an algorithm using a nonlinear model, is capable of accurately estimating a vehicle body slip angle irrespective of whether the frequency of occurrence of a state during traveling of the vehicle. A basic value-calculating section calculates a basic value of a vehicle body slip angle with an algorithm using a neural network model. A turning state-determining section determines whether the vehicle is in a predetermined limit turning traveling state. A correction value-calculating section calculates a correction value with an algorithm using a predetermined linear model when the vehicle is in the predetermined state. In the other cases, the correction value is set to 0. A straight traveling-determining section sets the angle to the sum of the basic value and the correction value when the vehicle is in a turning traveling state.

Abstract: A fuel control system for an internal combustion engine having an intake passage, a compressor provided in the intake passage, a throttle valve disposed downstream of the compressor, a bypass passage connecting an upstream side of the compressor to a downstream side of the compressor, and an air bypass valve provided in the bypass passage. An intake air flow rate of the engine is calculated based on the engine rotational speed and the intake pressure, which are detected when the air bypass valve is determined to be in the opening operation state. An amount of fuel supplied to the engine is then controlled according to the calculated intake air flow rate.

Abstract: A fuel control system for an internal combustion engine having an intake passage, a compressor provided in the intake passage, a throttle valve disposed downstream of the compressor, a bypass passage connecting an upstream side of the compressor to a downstream side of the compressor, and an air bypass valve provided in the bypass passage. An intake air flow rate of the engine is calculated based on the engine rotational speed and the intake pressure, which are detected when the air bypass valve is determined to be in the opening operation state. An amount of fuel supplied to the engine is then controlled according to the calculated intake air flow rate.