Abstract: The invention provides an antibody that specifically binds to a 5? to 3? exonuclease domain of a DNA polymerase, or a fragment thereof. The antibody inhibits the 5? to 3? exonuclease activity of a DNA polymerase, or a fragment thereof.

Abstract: The present invention provides an oil-in-water cosmetic excellent in emulsion stability. The oil-in-water cosmetic includes (a) oil-droplet particles consisting of an oil component to be emulsified; (b) vesicle particles for stabilizing the oil-droplet particles; and (c) an aqueous phase containing water and a monohydric aliphatic alcohol having 1 to 4 carbon atoms. It is preferred that the vesicle particles are formed with an amphiphilic substance which spontaneously forms vesicle particles, and that they are localized on surfaces of the oil-droplet particles. It is preferred that the amphiphilic substance be a polyoxyethylene hydrogenated castor oil derivative represented by the following formula (I), wherein E=L+M+N+X+Y+Z, and that said E which represents the average addition mole number of ethylene oxide is 10 to 20.

Abstract: The present invention provides an O/W emulsified composition which contains an organic UV absorber in an oil state such as octocrylene and a solid organic UV absorber, and is excellent in UV protection ability, formulation stability, and feeling in use. The composition according to the present invention is an O/W emulsified composition, comprising: (a) an organic UV absorber in an oil state at 20° C., comprising (a1) octocrylene; (b) an organic UV absorber in a solid state at 20° C.

Abstract: The invention is a sunscreen cosmetic containing (a) a specific hydrophobic zinc oxide powder, (b) decamethylcyclopentasiloxane, and (c) an alkyl trimethicone having 6 to 12 carbons. Hydrophobic powder that has the noticeable effects of low oil absorption and a low apparent specific volume is stably blended into a sunscreen cosmetic as a UV radiation dispersing agent to produce a sunscreen cosmetic that has remarkably improved ease of washability after use.

Abstract: The present invention provides an O/W emulsified composition excellent in formulation stability, feeling in use, and UV protection ability.

Abstract: A new emulsified cosmetic composition involving ?-gel, and the viscosity of the emulsified composition does not decrease over time even when salts are not added. The composition contains (A)-(E) ingredients, where (A) ingredient is a higher aliphatic alcohol, (B) ingredient is an anionic surfactant, (C) ingredient is a cationic surfactant, (D) ingredient is water, (E) ingredient is an oil component. The blend ratio of (B) ingredient is 1-15 times of the blend ratio of (C) ingredient in terms of the mole ratio.

Abstract: An O/W emulsion composition which is excellent in UV protection ability, formulation stability, and feeling in use. The O/W emulsion composition includes the following components (a) and (b): (a) organic UV absorbers comprising the following components (a1), (a2), and (a3): (a1) octocrylene, (a2) ethylhexyl methoxycinnamate, (a3) 4-t-butyl-4?-methoxydibenzoylmethane; and (b) a polyoxyethylene/polyoxyalkylene alkyl ether block polymer represented by the following formula (1) or (2); —R1O—(PO)m-(EO)n-H (1); R2O-(AO)p-(EO)q-R3 (2).

Abstract: The present invention provides an oil-in-water cosmetic excellent in emulsion stability. The oil-in-water cosmetic includes (a) oil-droplet particles consisting of an oil component to be emulsified; (b) vesicle particles for stabilizing the oil-droplet particles; and (c) an aqueous phase containing water and a monohydric aliphatic alcohol having 1 to 4 carbon atoms. It is preferred that the vesicle particles are formed with an amphiphilic substance which spontaneously forms vesicle particles, and that they are localized on surfaces of the oil-droplet particles. It is preferred that the amphiphilic substance be a polyoxyethylene hydrogenated castor oil derivative represented by the following formula (1), wherein E=L+M+N+X+Y+Z, and that said E which represents the average addition mole number of ethylene oxide is 10 to 20.

Abstract: The present invention provides an O/W emulsified composition which contains an organic UV absorber in an oil state such as octocrylene and a solid organic UV absorber, and is excellent in UV protection ability, formulation stability, and feeling in use. The composition according to the present invention is an O/W emulsified composition, comprising: (a) an organic UV absorber in an oil state at 20° C., comprising (a1) octocrylene; (b) an organic UV absorber in a solid state at 20° C.

Abstract: The present invention provides an O/W emulsified composition excellent in formulation stability, feeling in use, and UV protection ability.

Abstract: The cosmetic of the present invention is a cosmetic that alleviates skin irritation by blending in polypropylene glycol, a specific polar oil, or polybutylene glycol, as well as an ultraviolet absorbent. The present invention also relates to an agent and a method for alleviating irritation by lipophilic drugs. Since the present invention alleviates skin irritation due to ultraviolet absorbents and lipophilic drugs in cosmetics, any amount of ultraviolet absorbents and lipophilic drugs can be blended in cosmetics, and therefore cosmetics that can fully manifest their effects can be provided. Also, it is possible to prepare a safe sunblock cosmetic with superior ultraviolet protection effects because the ultraviolet absorbent is not absorbed through skin.

Abstract: The invention is a sunscreen cosmetic containing (a) a specific hydrophobic zinc oxide powder, (b) decamethylcyclopentasiloxane, and (c) an alkyl trimethicone having 6 to 12 carbons. Hydrophobic powder that has the noticeable effects of low oil absorption and a low apparent specific volume is stably blended into a sunscreen cosmetic as a UV radiation dispersing agent to produce a sunscreen cosmetic that has remarkably improved ease of washability after use.

Abstract: The cosmetic of the present invention is a cosmetic that alleviates skin irritation by blending in polypropylene glycol, a specific polar oil, or polybutylene glycol, as well as an ultraviolet absorbent. The present invention also relates to an agent and a method for alleviating irritation by lipophilic drugs. Since the present invention alleviates skin irritation due to ultraviolet absorbents and lipophilic drugs in cosmetics, any amount of ultraviolet absorbents and lipophilic drugs can be blended in cosmetics, and therefore cosmetics that can fully manifest their effects can be provided. Also, it is possible to prepare a safe sunblock cosmetic with superior ultraviolet protection effects because the ultraviolet absorbent is not absorbed through skin.

Abstract: The cosmetic of the present invention is a cosmetic that alleviates skin irritation by blending in polypropylene glycol, a specific polar oil, or polybutylene glycol, as well as an ultraviolet absorbent. The present invention also relates to an agent and a method for alleviating irritation by lipophilic drugs. Since the present invention alleviates skin irritation due to ultraviolet absorbents and lipophilic drugs in cosmetics, any amount of ultraviolet absorbents and lipophilic drugs can be blended in cosmetics, and therefore cosmetics that can fully manifest their effects can be provided. Also, it is possible to prepare a safe sunblock cosmetic with superior ultraviolet protection effects because the ultraviolet absorbent is not absorbed through skin.

Abstract: External skin preparations with a sun-screening effect are frequently blended with an ultraviolet absorbent octyl methoxycinnamate together with ultraviolet reflectors titanium oxide and zinc oxide in powder. The skin irritation of octyl methoxycinnamate is enhanced when blended with the powders of titanium oxide and zinc oxide and the like. It is an object of the invention to provide an external skin preparation capable of reducing the skin irritation.

Abstract: The cosmetic of the present invention is a cosmetic that alleviates skin irritation by blending in polypropylene glycol, a specific polar oil, or polybutylene glycol, as well as an ultraviolet absorbent. The present invention also relates to an agent and a method for alleviating irritation by lipophilic drugs. Since the present invention alleviates skin irritation due to ultraviolet absorbents and lipophilic drugs in cosmetics, any amount of ultraviolet absorbents and lipophilic drugs can be blended in cosmetics, and therefore cosmetics that can fully manifest their effects can be provided. Also, it is possible to prepare a safe sunblock cosmetic with superior ultraviolet protection effects because the ultraviolet absorbent is not absorbed through skin.

Abstract: This invention relates to an oil-in-water-in-oil (O/W/O) type multiple emulsion which contains an inner oil phase, a water phase, and an outer oil phase. The inner oil phase is first dispersed in water to form an oil-in-water (O/W) emulsion. Then, the O/W emulsion is further dispersed in the outer oil phase to form the O/W/O type multiple emulsion. The outer oil phase contains an organophilic clay mineral, which can effectively prevent the inter-mixing of the inner oil phase with the outer oil phase, thus, producing an O/W/O type multiple emulsion with excellent storage stability. Upon the using of an oil-soluble compound in the inner oil phase, this multiple emulsion system can prevent the oil-soluble compound from being oxidized.