Patents by Inventor Takafumi Mukaihira

Takafumi Mukaihira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tricyclic compound having spiro union
    Patent number: 7122662
    Abstract: This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action. The invention also relates to a pharmacophore which was derived from the compound and is useful in molecular designing of the FXa inhibitor.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: October 17, 2006
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Hidemitsu Nishida, Fumihiko Saitoh, Kousuke Harada, Ikuya Shiromizu, Takafumi Mukaihira
  • Tricyclic compound having spiro union
    Publication number: 20050148769
    Abstract: This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action. The invention also relates to a pharmacophore which was derived from the compound and is useful in molecular designing of the FXa inhibitor.
    Type: Application
    Filed: December 16, 2004
    Publication date: July 7, 2005
    Inventors: Hidemitsu Nishida, Fumihiko Saitoh, Kousuke Harada, Ikuya Shiromizu, Takafumi Mukaihira
  • Tricyclic compound having spiro union
    Patent number: 6858599
    Abstract: This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action. The invention also relates to a pharmacophore which was derived from the compound and is useful in molecular designing of the FXa inhibitor.
    Type: Grant
    Filed: December 27, 2001
    Date of Patent: February 22, 2005
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Hidemitsu Nishida, Fumihiko Saitoh, Kousuke Harada, Ikuya Shiromizu, Takafumi Mukaihira
  • Cholesterol biosynthesis inhibitors containing as the active ingredient tricyclic spiro compounds
    Publication number: 20040063716
    Abstract: This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action.
    Type: Application
    Filed: June 25, 2003
    Publication date: April 1, 2004
    Inventors: Hidemitsu Nishida, Takafumi Mukaihira
  • Tricyclic compound having spiro union
    Publication number: 20030045520
    Abstract: This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action.
    Type: Application
    Filed: December 27, 2001
    Publication date: March 6, 2003
    Inventors: Hidemitsu Nishida, Fumihiko Saitoh, Kousuke Harada, Ikuya Shiromizu, Takafumi Mukaihira
  • Nerve cell protective agents
    Patent number: 6040331
    Abstract: The invention provides novel benzindole derivatives, processes for producing them, as well as a neuroprotective agent, an agent to prevent or treat diseases involving the degeneration, retraction or death of neurons, and an analgesic, each containing the benzindole derivatives as an active ingredient.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: March 21, 2000
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Ichiro Yamamoto, Manabu Itoh, Masato Shimojo, Yasunobu Yumiya, Takafumi Mukaihira, Yasushige Akada