Patents by Inventor Takaharu Matsuura
Takaharu Matsuura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11307076Abstract: In this vortex flowmeter provided with a vortex generator and a flow rate measuring unit, a seal member is mounted on a temperature sensing element including a temperature sensor adhered with an adhesive to a metal temperature sensing case. The temperature sensing element is inserted into a first insertion hole formed in a body case so as to communicate with a body passage. A distal end surface of the temperature sensing element is arranged in either a position where the distal end surface is flush with the passage surface of the body passage formed in the body case or a position more outside than the passage surface in the radial direction of the body passage.Type: GrantFiled: August 24, 2018Date of Patent: April 19, 2022Assignee: CKD CORPORATIONInventors: Yasushi Ohshima, Ryo Eguchi, Takaharu Matsuura, Yuki Sakaki
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Patent number: 11060892Abstract: In this vortex flowmeter provided with a vortex generator and a flow rate measuring unit the flow rate measurement unit includes a piezoelectric element and a piezoelectric element case. The piezoelectric element case includes: a fitted part fitted in the body case; a pressure receiving part protruding out from a distal end face of the fitted part and placed in a body passage; a hollow portion formed along the axial direction of the piezoelectric element case in the fitted part to separate the fitted part and the pressure receiving part; and a slit formed inside of the pressure receiving part and configured to accommodate the piezoelectric element.Type: GrantFiled: August 24, 2018Date of Patent: July 13, 2021Assignee: CKD CORPORATIONInventors: Yasushi Ohshima, Yuki Sakaki, Takaharu Matsuura, Ryo Eguchi
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Publication number: 20210072065Abstract: In this vortex flowmeter provided with a vortex generator and a flow rate measuring unit, a seal member is mounted on a temperature sensing element including a temperature sensor adhered with an adhesive to a metal temperature sensing case. The temperature sensing element is inserted into a first insertion hole formed in a body case so as to communicate with a body passage. A distal end surface of the temperature sensing element is arranged in either a position where the distal end surface is flush with the passage surface of the body passage formed in the body case or a position more outside than the passage surface in the radial direction of the body passage.Type: ApplicationFiled: August 24, 2018Publication date: March 11, 2021Applicant: CKD CORPORATIONInventors: Yasushi OHSHIMA, Ryo EGUCHI, Takaharu MATSUURA, Yuki SAKAKI
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Publication number: 20210072051Abstract: In this vortex flowmeter provided with a vortex generator and a flow rate measuring unit the flow rate measurement unit includes a piezoelectric element and a piezoelectric element case. The piezoelectric element case includes: a fitted part fitted in the body case; a pressure receiving part protruding out from a distal end face of the fitted part and placed in a body passage; a hollow portion formed along the axial direction of the piezoelectric element case in the fitted part to separate the fitted part and the pressure receiving part; and a slit formed inside of the pressure receiving part and configured to accommodate the piezoelectric element.Type: ApplicationFiled: August 24, 2018Publication date: March 11, 2021Applicant: CKD CORPORATIONInventors: Yasushi OHSHIMA, Yuki SAKAKI, Takaharu MATSUURA, Ryo EGUCHI
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Patent number: 5585501Abstract: A method for reduction of an allyl alcohol-type compound, specific to its allylic hydroxyl group, being carried out without any side reactions such as reduction of other portions of the compound or allylic rearrangement, which comprises treating the compound with trialkylsilane in the presence of AlX.sub.3, wherein X refers to a halogen atom.Type: GrantFiled: May 30, 1995Date of Patent: December 17, 1996Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Takaharu Matsuura, Yoshinori Hamada, Isamu Yamada, Teruo Sakata, Kimio Takahashi, Morio Kishi
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Patent number: 5534654Abstract: A novel hydroxamic acid compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof having cell growth inhibition, vascularization inhibition activities and the like.The compounds of the present invention possess inhibitory activities against the growth of vascular endothelial cells and the expression of lymphocyte adhesive factors and the detransforming activity of cells transformed by ras gene, and inhibit the cell growth and are effective on inflammation and tumor.Type: GrantFiled: August 3, 1993Date of Patent: July 9, 1996Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Hitoshi Arita, Kenji Sugita, Takaharu Matsuura, Kazuhiro Shirahase
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Patent number: 5241104Abstract: Optically active mono-esters of dicarboxylic acid of the formula III: ##STR1## being useful as intermediates for preparing optically active natural products or medicines; asymmetric synthesis process for preparing thereof being characterized by the reaction of an acid anhydride with an (R)- or (S)-arylacetic acid derivative; and the key substances therefor are also claimed.Type: GrantFiled: June 23, 1992Date of Patent: August 31, 1993Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Takaharu Matsuura
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Patent number: 5183909Abstract: Optically active mono-esters of dicarboxylic acid of the formula III: ##STR1## being useful as intermediates for preparing optically active natural products or medicines; asymmetric synthesis process for preparing thereof being characterized by the reaction of an acid anhydride with an (R)- or (S)-arylacetic acid derivative; and the key substances therefor are also claimed.Type: GrantFiled: June 20, 1991Date of Patent: February 2, 1993Assignee: Shionogi & Company, Ltd.Inventors: Mitsuaki Ohtani, Takaharu Matsuura
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Patent number: 5175341Abstract: Optically active mono-esters of dicarboxylic acid of the formula III: ##STR1## being useful as intermediates for preparing optically active natural products or medicines; asymmetric synthesis process for preparing thereof being characterized by the reaction of an acid anhydride with an (R)- or (S)-arylacetic acid derivative; and the key substances therefor are also claimed.Type: GrantFiled: June 20, 1991Date of Patent: December 29, 1992Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Takaharu Matsuura
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Patent number: 5137914Abstract: Sulfonylamino substituted bicyclyl hydroxamic acid derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each is hydrogen or lower alkyl; R.sup.3 is hydrogen, lower alkyl, lower alkoxy, hydroxy or halogen; X is alkylene or alkenylene: Y is methylene or oxygen; and n is 0, 1, or 2, or the pharmaceutically acceptable salt thereof. These compounds have an advanced antagonistic activity to thromboxane A.sub.2 (TXA.sub.2)-receptor and are useful for the treatment of thrombosis, vasoconstriction, or bronchoconstriction, and the like disease which are induced by TXA.sub.2.Type: GrantFiled: March 15, 1991Date of Patent: August 11, 1992Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Takaharu Matsuura, Kazuhiro Shirahase
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Patent number: 5124462Abstract: A process for preparing a compound of Formula (I): ##STR1## wherein R' is optionally protected --CH.sub.2 OH or --COOH; R.sup.2 is phenyl or substituted phenyl; and Y is oxygen, methylene, or substituted methylene, which comprises treating a norbornyl acid amide of formula (II): ##STR2## wherein R is optionally protected --CH.sub.2 OH or --COOR.sup.1 ; R.sup.1 is hydrogen or ester-forming group; and Y is oxygen, methylene, or substituted methylene under the reaction conditions for the Hofmann Rearrangement, and then with a substituted sulfonyl halide of formula (III):R.sup.2 SO.sub.2 X (III)wherein R.sup.2 is phenyl or substituted phenyl; and X is halogen atom.Type: GrantFiled: June 18, 1991Date of Patent: June 23, 1992Assignee: Shiongi & Co., Ltd.Inventors: Mitsuaki Ohtani, Takaharu Matsuura, Yoshinori Hamada, Shoji Shinomoto
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Patent number: 5117039Abstract: An optically active ester of arylacetic acid of the fomula: ##STR1## wherein R.sup.1 is hydrogen or optionally substituted C.sub.1 -C.sub.2 alkyl or phenyl or taken together to from C.sub.2 -C.sub.6 alkylene, or C.sub.2 C.sub.4 -C.sub.6 alkenylene, or bicyclic-ring; R.sup.2 is hydrogen or methyl; X is single bond or Ch.sub.2, C.dbd.O, N--R.sup.4, O, S, CHNHR.sup.4, CHCH.sub.3, CH--Ar, or CHOR.sup.5 (provided that when X is single bond or CH.sub.2, C.dbd.O, N--R.sup.4, O, or S, R.sup.1 and R.sup.2 are not simultaneouly hydrogen or methyl); R.sup.3 is hydrogen, optionally substituted alkyl, or optionally substituted aralkyl; R.sup.4 is hydrogen or amino protecting group; R.sup.5 is hydrogen or hydroxy protecting group; and Ar is optionally substituted aryl; prepared by the reaction of a 94 symmetric acid anhydride with an (R)-or (S)-arylacetic acid derivative in high optical purity; useful as a intermediate for the various optically active natural products and medicines.Type: GrantFiled: December 7, 1989Date of Patent: May 26, 1992Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Takaharu Matsuura, Toshiro Konoike, Yoshitaka Araki
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Patent number: 5047574Abstract: Optically active mono-esters of dicarboxylic acid of the formula III: ##STR1## being useful as intermediates for preparing optically active natural products or medicines; asymmetric synthesis process for preparing thereof being characterized by the reaction of an acid anhydride with an (R)- or (S)-arylacetic acid derivative; and the key substances therefor are also claimed.Type: GrantFiled: December 12, 1989Date of Patent: September 10, 1991Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Takaharu Matsuura
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Patent number: 5002972Abstract: Pharmaceutical compounds and compositions for injectable use in the treatment of thromboxane A.sub.2 mediating diseases, comprising a pharmaceutical carrier and a pharmacologically effective amount of a compound of the formula: ##STR1## wherein R.sup.1 is carboxyl or 5-tetrazolyl; R.sup.2 is hydrogen, methyl, hydroxy, chloro, or bromo; or a pharmaceutically acceptable ester or salt thereof, together with one or more non-toxic pharmaceutically acceptable carriers; and methods for treating thromboxane A.sub.2 mediating diseases.Type: GrantFiled: February 7, 1990Date of Patent: March 26, 1991Assignee: Shionogi & Co., Ltd.Inventors: Masayuki Narisada, Mitsuaki Ohtani, Fumihiko Watanabe, Takaharu Matsuura
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Patent number: 4916231Abstract: Tetrazole derivatives represented by the formula: ##STR1## wherein R is naphthyl or phenyl optionally substituted by phenyl, lower alkyo, halogen, lower alkoxy, hydroxy or acetoxy; X is methylene, dimethylmethylene or oxygen; n is an integer of 0 or 1; and p and r each is an integer of 0 or 1 and q is an integer of 1 or 2 provided that p+q+r=2; or a tautomer in tetrazole ring and a pharmaceutically acceptable salt thereof, which are useful as TXA.sub.2 receptor antagonist.Type: GrantFiled: July 10, 1989Date of Patent: April 10, 1990Assignee: Shionogi & Co., Ltd.Inventors: Masayuki Narisada, Mitsuaki Ohtani, Fumihiko Watanabe, Takaharu Matsuura, Sanji Hagishita, Kaoru Seno