Abstract: The disclosure provides a composition for improving cardiac function comprising a compound of formula (I) or an ester, oxide, prodrug, pharmaceutically acceptable salt, or solvate thereof. The disclosure also provides a composition for treating heart failure comprising a compound of formula (I) or an ester, oxide, prodrug, pharmaceutically acceptable salt, or solvate thereof.

Abstract: A multi-blade centrifugal air-sending device includes a fan including a back plate having a disk shape, a plurality of blades arranged at a peripheral portion of the back plate in a circumferential direction, and a rim having an annular shape and coupling the plurality of blades to each other, the plurality of blades being connected at respective first end portions on one side to the back plate, the rim being provided at respective second end portions of the plurality of blades on a side opposite to the one side where the respective first end portions are present; and a scroll casing having a spiral shape and including a facing side wall where an air inlet is provided and a peripheral wall, the scroll casing housing the fan such that the side wall faces the respective second end portions of the plurality of blades, the scroll casing being configured such that air is introduced through the air inlet and blown out to the outer peripheral side.

Abstract: A prophylactic or therapeutic agent for a myopathy, including a miR-33b inhibitor, preferably an antisense oligonucleotide against miR-33b, as an effective component.

Abstract: The inventors have found that the compounds of formula (I) protect cardiomyocytes. Accordingly, the disclosure provides a pharmaceutical composition for protecting a cardiomyocyte comprising a compound of formula (I) or an ester, oxide, pharmaceutically acceptable salt or solvate thereof. The pharmaceutical composition may be used for treating or preventing a disease associated with cardiomyocyte death, such as myocardial infarction, chronic heart failure, hypertensive heart failure, or dilated cardiomyopathy, especially for treating myocardial infarction.

Abstract: A first sealing composition includes an epoxy resin, a curing agent, an inorganic filler, and an unbaked hydrotalcite compound having a mole ratio of Mg ion to Al ion (Mg/Al) of 2.4 or more. A second sealing composition includes an epoxy resin, a curing agent, a hydrotalcite compound represented by Formula (1): Mg1-xAlx(OH)2(CO3)x/2·mH2O, in which each of x and m independently represents a positive number, and a magnesium-containing compound that is different from the hydrotalcite compound. A third sealing composition includes an epoxy resin, a curing agent, a hydrotalcite compound represented by Formula (I), and a magnesium oxide, and a content of the magnesium oxide is from 1 part by mass to 50 parts by mass parts with respect to 100 mass parts of the epoxy resin.

Abstract: An object of the present invention is to provide a therapeutic agent for hereditary spastic paraplegia (HSP) SPG4. Specifically, the present invention relates to a composition for preventing or treating a neurodegenerative disease such as hereditary spastic paraplegia SPG4, the composition comprising, as an active ingredient, a substance that inhibits a function of miR-33a.

Abstract: A prophylactic or therapeutic agent for an aneurysm comprising a miR-33b inhibiting substance, preferably an antisense oligonucleotide against miR-33b, as an active ingredient.

Abstract: An object of the present invention is to provide a therapeutic agent for hereditary spastic paraplegia (HSP) SPG4. Specifically, the present invention relates to a composition for preventing or treating a neurodegenerative disease such as hereditary spastic paraplegia SPG4, the composition comprising, as an active ingredient, a substance that inhibits a function of miR-33a.

Abstract: The inventors have found that the compounds of formula (I) protect cardiomyocytes. Accordingly, the disclosure provides a pharmaceutical composition for protecting a cardiomyocyte comprising a compound of formula (I) or an ester, oxide, pharmaceutically acceptable salt or solvate thereof. The pharmaceutical composition may be used for treating or preventing a disease associated with cardiomyocyte death, such as myocardial infarction, chronic heart failure, hypertensive heart failure, or dilated cardiomyopathy, especially for treating myocardial infarction.

Abstract: A first sealing composition includes an epoxy resin, a curing agent, an inorganic filler, and an unbaked hydrotalcite compound having a mole ratio of Mg ion to Al ion (Mg/Al) of 2.4 or more. A second sealing composition includes an epoxy resin, a curing agent, a hydrotalcite compound represented by Formula (1): Mg1-xAlx(OH)2(CO3)x/2.mH2O, in which each of x and m independently represents a positive number, and a magnesium-containing compound that is different from the hydrotalcite compound. A third sealing composition includes an epoxy resin, a curing agent, a hydrotalcite compound represented by Formula (I), and a magnesium oxide, and a content of the magnesium oxide is from 1 part by mass to 50 parts by mass parts with respect to 100 mass parts of the epoxy resin.

Abstract: A frequency shift keying digital signal receiving apparatus includes a detecting portion detecting a new signal on the basis of a signal, from which a correlated ambient noise is filtered out by an adaptive filter, a holding portion holding a first electric power for the signal received before a new signal is detected, a calculating portion calculating a second electric power for the signal received after the new signal is detected, a comparing portion comparing levels of the first and second electric powers, a selector selecting the signal, from which the correlated ambient noise is filtered out, when the first electric power is higher than the second electric power and selecting the signal bypassing the adaptive filter when the first electric power is lower than the second electric power, and a demodulating portion demodulating a desired signal on the basis of the signal selected by the selecting portion.

Abstract: A digital signal receiving apparatus includes a detection-judging portion having a first smoothing filter generating a first smoothed signal by smoothing an auto-correlation signal and judging a possible presence of a desired signal when a signal level of the first smoothed signal is greater than a reference level and an absence of the desired signal when being smaller than the reference level. The smoothing filter includes a limiting portion limiting a fluctuation width of the first smoothed signal; and an adjusting portion configured to adjust the fluctuation width of the first smoothed signal limited by the limiting portion to be reduced while an elapsing time after the detection-judging means judges the possible presence of the desired signal is increasing.

Abstract: A digital signal receiving apparatus includes: detection-judging portion judging a possible presence of a desired signal when a signal level of a smoothed signal is greater than a reference level; wherein said first smoothed signal and said second smoothed signal are compared in order to generate a detection signal representing a judgment of a possible presence of a desired signal, said second smoothed signal having a convergence speed slower than that of the first smoothing filter, a filter controlling portion switching an adaptive filter from an adaptive mode to a non-adaptive mode when the detection-judging portion judges the possible presence of the desired signal and switching from the non-adaptive mode to the adaptive mode when the detection-judging portion judges the absence of the desired signal; a limiting portion limiting a signal level of an auto-correlation signal to the signal level of the smoothed signal; and a demodulating portion demodulating the auto-correlation signal having the signal level

Abstract: A digital signal receiving apparatus includes: detection-judging portion judging a possible presence of a desired signal when a signal level of a smoothed signal is greater than a reference level; wherein said first smoothed signal and said second smoothed signal are compared in order to generate a detection signal representing a judgment of a possible presence of a desired signal, said second smoothed signal having a convergence speed slower than that of the first smoothing filter, a filter controlling portion switching an adaptive filter from an adaptive mode to a non-adaptive mode when the detection-judging portion judges the possible presence of the desired signal and switching from the non-adaptive mode to the adaptive mode when the detection-judging portion judges the absence of the desired signal; a limiting portion limiting a signal level of an auto-correlation signal to the signal level of the smoothed signal; and a demodulating portion demodulating the auto-correlation signal having the signal level

Abstract: A digital signal receiving apparatus includes a detection-judging portion having a first smoothing filter generating a first smoothed signal by smoothing an auto-correlation signal and judging a possible presence of a desired signal when a signal level of the first smoothed signal is greater than a reference level and an absence of the desired signal when being smaller than the reference level. The smoothing filter includes a limiting portion limiting a fluctuation width of the first smoothed signal; and an adjusting portion configured to adjust the fluctuation width of the first smoothed signal limited by the limiting portion to be reduced while an elapsing time after the detection-judging means judges the possible presence of the desired signal is increasing.

Abstract: A frequency shift keying digital signal receiving apparatus includes a detecting portion detecting a new signal on the basis of a signal, from which a correlated ambient noise is filtered out by an adaptive filter, a holding portion holding a first electric power for the signal received before a new signal is detected, a calculating portion calculating a second electric power for the signal received after the new signal is detected, a comparing portion comparing levels of the first and second electric powers, a selector selecting the signal, from which the correlated ambient noise is filtered out, when the first electric power is higher than the second electric power and selecting the signal bypassing the adaptive filter when the first electric power is lower than the second electric power, and a demodulating portion demodulating a desired signal on the basis of the signal selected by the selecting portion.

Abstract: An epoxy resin composition for semiconductor sealing, which comprises an epoxy resin, a curing agent and an inorganic filler, and has a J-value of 10 to 50, which is a maximum jetting flow value determined according to a method of evaluating jetting flow of epoxy resin composition.