Abstract: The present invention provides compositions comprising a protein expression blocker or PEBL comprising a target-binding molecule and localizing domain, and methods of using such compositions in cancer therapy. PEBLs are useful as a blockade of expression of target surface receptors (peptides or antigens) in immune cells. Also provided herein are CD3/TCR??-deficient T cells and CD3/TCR??-deficient chimeric antigen receptor T cells that express such PEBLs.

Abstract: The present invention provides compositions comprising a protein expression blocker or PEBL comprising a target-binding molecule and localizing domain, and methods of using such compositions in cancer therapy. PEBLs are useful as a blockade of expression of target surface receptors (peptides or antigens) in immune cells. Also provided herein are CD3/TCR??-deficient T cells and CD3/TCR??-deficient chimeric antigen receptor T cells that express such PEBLs.

Abstract: A lawn mower having a lateral-side discharge outlet in a body housing for discharging mowed lawn has been configured such that a discharge outlet door for closing the lateral-side discharge outlet is held at a closed position only by a spring force, and therefore, there has been a risk of causing fluttering due to a blowing pressure and vibrations generated by the rotation of a mowing blade. An object of the present invention is to avoid fluttering of the discharge outlet door. In order to avoid fluttering, a lock device (20) is disposed at a discharge outlet door (16) for locking it at a closed position. The lock device (20) is unlocked by an unlock operation by the user, so that accidental opening can be prevented. By setting a spring to be weak, the discharge outlet door (16) can be easily opened.

Abstract: The present invention provides compositions comprising an anti-CD7 chimeric activating receptor (CAR) and an anti-CD7 protein expression blocker, and methods of using such compositions in cancer therapy.

Abstract: The present invention provides compositions comprising an anti-CD7 chimeric activating receptor (CAR) and an anti-CD7 protein expression blocker, and methods of using such compositions in cancer therapy.

Abstract: The present invention relates to a method of using a receptor (e.g., chimeric antigen receptor—CAR) that activates an immune response upon binding a cancer cell ligand in conjunction with a target-binding molecule that targets a protein or molecule CI for removal or neutralization to generate enhanced anti-cancer immune cells. The present invention also relates to engineered immune cells having enhanced therapeutic efficacy and uses thereof.

Abstract: A hydroponic system (1) is provided with a light-collecting apparatus (3) having a pair of reflecting plates (31a) that are vertically arranged in parallel with a culture surface (23) of a culture panel (21) of a hydroponic unit (2). During a process in which natural light taken from a light-collecting opening (30) propagates while repeatedly reflected by opposing reflecting surfaces of a reflecting plates (31a), by allowing seedlings p that are transplanted into the culture panel (21) to be irradiated with the light through a light-emitting hole (32) bored in the reflecting plate (31a), a culture object can be grown efficiently at a low cost by taking natural light from the outside.

Abstract: A container for heat treatment of a positive-electrode active material for a lithium-ion battery to the present invention is characterized by having a base portion containing 60 to 95 mass % of alumina, and a surface portion containing 20 to 80 mass % of spinel and formed integrally with the base portion. Moreover, a production method of the present invention is characterized by comprising a step of placing an alumina-based powder, a step of placing a spinel-based powder above the alumina-based powder, a step of forming a compact by compressing the powders and a step of firing the compact.

Abstract: A power tool includes an inner housing (50) at least partially housed within and spaced from an outer housing (30). The inner housing supports a tool (102, 302), such as a pair of shear blades, and houses a motor (80) that drives the tool. The outer housing includes a grip (14, 18) to be grasped by a user. At least one vibration insulator (71-75) can be disposed between the inner housing and the outer housing and in a manner such that the vibration insulator(s) is(are) protected by the outer housing. An intake opening (60a, 60b) and exhaust opening (64a, 64b) can be formed in the inner housing and can be shielded by respective portions of an inner surface of the outer housing.

Abstract: A container for heat treatment of a positive-electrode active material for a lithium-ion battery to the present invention is characterized by having a base portion containing 60 to 95 mass % of alumina, and a surface portion containing 20 to 80 mass % of spinel and formed integrally with the base portion. Moreover, a production method of the present invention is characterized by comprising a step of placing an alumina-based powder, a step of placing a spinel-based powder above the alumina-based powder, a step of forming a compact by compressing the powders and a step of firing the compact.

Abstract: A container for heat treatment of a positive-electrode active material of a lithium ion battery to hold raw material powder of the positive-electrode active material of the lithium ion battery when the raw material powder is subjected to heat treatment is provided. The heat treatment container contains 60 to 95 mass % of alumina and 10 to 20 mass % of silica, is free from MgO, ZrO2 and Li compounds, and has a porosity of 10 to 20%. The heat treatment container suppresses a reaction product from contaminating the raw material powder owing to suppressed reactivity with the raw material powder, and is suppressed from being cracked by thermal shock owing to the porosity in the predetermined range.

Abstract: A brush cutter is provided with an operating rod, a cord holder configured to be rotatably driven at a front end of the operating rod, a cutting cord held by the cord holder and configured that a tip of the cutting cord is drawn out from the cord holder, and an under cover configured to cover from an under side a part of a region in which the cutting cord extending from the cord holder revolves. The cord holder is provided with a cord feeding button that projects downward and is configured to feed the cutting cord by being pressed. The under cover is provided with an opening that exposes the cord feeding button.

Abstract: A power tool includes an inner housing (50) at least partially housed within and spaced from an outer housing (30). The inner housing supports a tool (102, 302), such as a pair of shear blades, and houses a motor (80) that drives the tool. The outer housing includes a grip (14, 18) to be grasped by a user. At least one vibration insulator (71-75) can be disposed between the inner housing and the outer housing and in a manner such that the vibration insulator(s) is(are) protected by the outer housing. An intake opening (60a, 60b) and exhaust opening (64a, 64b) can be formed in the inner housing and can be shielded by respective portions of an inner surface of the outer housing.

Abstract: It is an object of the invention to provide a dust collecting circular saw in which cooling air to cool the motor can be further effectively utilized. According to the present invention, a representative dust collecting circular saw may comprise a blade, a motor, a cooling fan, a dust case, a dust case cover and an air space between the dust case cover and the dust case. The cooling air to cool the motor is designed to be introduced into the air space. Therefore, according to the invention, heat of the dust case caused by hot chips collected within the dust case can be prevented from being transferred from the dust case to the dust case cover by the air space into which the cooling air is introduced. Thus, the user of the circular saw can securely be escaped from contacting any circular saw members heated by the hot chips within the dust case.

Abstract: A cutting tool that improves operability by facilitating operation of a lever for operating a clamp mechanism of a guide member is provided. A clamp mechanism is constituted by a clamp pin that protrudes its distal end to the outside of the blade case while penetrating a depth guide and the blade case, a first lever that is connected to the distal end of the clamp pin and directly moves the clamp pin in the axial direction, and a second lever that is connected to the upper portion of the first lever through a connecting pin and has a cam lever. When the second lever is rotated toward the blade case, the cam lever presses the connecting pin to tilt the first lever, whereby the clamp pin is pulled outward. As a result, the depth guide is pressed to the inner surface of the blade case and clamped.

Abstract: A cutting tool that improves operability by facilitating operation of a lever for operating a clamp mechanism of a guide member is provided. A clamp mechanism is constituted by a clamp pin that protrudes its distal end to the outside of the blade case while penetrating a depth guide and the blade case, a first lever that is connected to the distal end of the clamp pin and directly moves the clamp pin in the axial direction, and a second lever that is connected to the upper portion of the first lever through a connecting pin and has a cam lever. When the second lever is rotated toward the blade case, the cam lever presses the connecting pin to tilt the first lever, whereby the clamp pin is pulled outward. As a result, the depth guide is pressed to the inner surface of the blade case and clamped.

Abstract: It is an object of the invention to provide a dust collecting circular saw in which cooling air to cool the motor can be further effectively utilized. According to the present invention, a representative dust collecting circular saw may comprise a blade, a motor, a cooling fan, a dust case, a dust case cover and an air space between the dust case cover and the dust case. The cooling air to cool the motor is designed to be introduced into the air space. Therefore, according to the invention, heat of the dust case caused by hot chips collected within the dust case can be prevented from being transferred from the dust case to the dust case cover by the air space into which the cooling air is introduced. Thus, the user of the circular saw can securely be escaped from contacting any circular saw members heated by the hot chips within the dust case.