Patents by Inventor Takahiro Kumonaka

Takahiro Kumonaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,4-benzoxazine-2-acetic acid compound, method for production thereof and use thereof
    Patent number: 5635505
    Abstract: A 1,4-benzoxazine-2-acetic acid compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, a method for production thereof, and a pharmaceutical composition, an aldose reductase inhibitor and an agent for the prevention and/or treatment of the complications of diabetes, which contain the same. The compound (I) of the present invention and pharmaceutically acceptable salts thereof have aldose reductase inhibitory action and are superior in safety. Accordingly, they are useful as an agent for the prevention and/or treatment of the complications of diabetes such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, in particular, cataract and neurosis.
    Type: Grant
    Filed: July 3, 1996
    Date of Patent: June 3, 1997
    Assignees: Senju Pharmaceutical Co., Ltd., The Green Cross Corporation
    Inventors: Takahiro Kumonaka, Takema Hase, Tomoji Aotsuka, Toshio Kurihara, Yoshiyuki Nakamura, Tetsuo Matsui, Hiromichi Ishikawa, Fujio Kobayashi
  • Benzothiazole compound, production thereof and use thereof
    Patent number: 5532257
    Abstract: Production of a benzothiazole compound of the formula (I) ##STR1## wherein R.sup.1 is a halogen atom, R.sup.2 and R.sup.3 may be the same or different and each is a hydrogen atom or a halogen atom, R.sup.4 is a hydrogen atom, a halogen atom, a lower alkyl, an alkoxy or an alkyl mercapto and R.sup.5 is a hydrogen atom or a lower alkyl, or a pharmaceutically acceptable salt thereof.The compound of the formula (I) and a pharmaceutically acceptable salt thereof of the present invention have an aldose reductase inhibitory activity in mammals inclusive of human and have superior safety. Accordingly, they are useful as pharmaceutical compositions for the treatment of the complications of diabetes, such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, particularly cataract and neurosis.
    Type: Grant
    Filed: November 25, 1994
    Date of Patent: July 2, 1996
    Assignees: Senju Pharmaceutical Co., Ltd, The Green Cross Corporation
    Inventors: Takema Hase, Takahiro Kumonaka, Chikako Shimizu, Hiroshi Hosono, Tomoji Aotsuka, Yoshiyuki Nakamura, Tetsuo Matsui, Hiromichi Ishikawa
  • Amide derivatives and antiallergic agents containing the same
    Patent number: 4859673
    Abstract: Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned 1-[2-(5-(3-methoxy-4-benzyloxyphenyl)-2,4-pentadienoyl)aminoethyl]-4-diphe nylmethoxypiperidine, 1-[2-(5-(3-methoxy-4-pentadienoyl)aminoethyl]-4-diphenylmethoxypiperidine and 1-[2-(5-(3-methoxy-4-ethoxymethoxyphenyl)-2,4-pentadienoyl)aminoethyl]-4-d iphenylmethoxypiperidine. These amide derivatives are useful as antiallergic agents.
    Type: Grant
    Filed: April 23, 1987
    Date of Patent: August 22, 1989
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Makoto Takai, Kazuhiro Omori, Takahiro Kumonaka, Shinji Ozawa, Toshio Wakabayashi
  • Nitrate derivatives and vasodilators containing the same
    Patent number: 4780560
    Abstract: Novel nitrate derivatives are disclosed. As examples of said nitrate derivative are described N-(.beta.-hydroxyethyl)-5-(3,4,5-trimethoxyphenyl)2,4-pentadienoic acid amide nitrate, N-(.beta.-hydroxyethyl)-3,4,5-trimethoxycinnamic acid amide nitrate and the like. These nitrate derivatives are useful as vasodilators.
    Type: Grant
    Filed: March 2, 1987
    Date of Patent: October 25, 1988
    Assignee: Terumo Corporation
    Inventors: Takahiro Kumonaka, Shigeru Taguchi, Yasushi Suwabe, Toshio Wakabayashi
  • 1-[5-(3,4,5-Trimethoxy phenyl)-2,4-pentadienoyl]-4-(substituted carbonylmethyl)-piperazines having vasodilating activity
    Patent number: 4656172
    Abstract: There are disclosed novel piperazine derivatives and vasodilators containing the same. The compounds are useful for controlling or preventing vascular disorders such as cerebral embolism, myocardial infarction and limb arterial obstruction. As typical compounds are mentioned 1-[5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-4-(pyrrolidinocarbonylmeth yl)-piperazine, 1-[5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-4-(N-isopropylaminocarbony lmethyl)-piperazine, 1-[5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-4-(N,N-dimethylaminocarbon ylmethyl)piperazine and 1-[5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-4-(methylaminocarbonylmeth yl)-piperazine.
    Type: Grant
    Filed: September 16, 1985
    Date of Patent: April 7, 1987
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Toshio Wakabayashi, Takahiro Kumonaka, Yasushi Suwabe