Abstract: A method for designing a protein capable of binding in an RNA base selective manner or RNA base sequence specific manner is provided.

Abstract: An electrophotographic photoreceptor includes a conductive substrate; an undercoat layer formed on the conductive substrate and containing a polyurethane resin, metal oxide particles, a silane coupling agent, and a compound represented by General Formula (ID); and a photosensitive layer formed on the undercoat layer (where R1 to R8 each independently represent a hydrogen atom, a nitro group, a cyano group, a halogen atom, a hydroxyl group, a saturated or unsaturated aliphatic hydrocarbon group optionally having a substituent, an aromatic hydrocarbon group optionally having a substituent, an alkoxy group optionally having a substituent, an aryloxy group optionally having a substituent, a sulfo group optionally having a substituent, an amino group, an alkylamino group optionally having a substituent, or an arylamino group optionally having a substituent).

Abstract: The object of the present invention is to generalize and improve DNA-binding proteins using PPR. There is provided a protein that contains one or more PPR motifs having a structure of the following formula 1, wherein one PPR motif (Mn) contained in the protein is a PPR motif having a specific combination of amino acids corresponding to a target DNA base or target DNA base sequence as the three amino acids of No. 1 A.A., No. 4 A.A., and No. “ii” (?2) A.A, and satisfies at least one selected from the group consisting of the following conditions (a) to (h): (a) No. 7 A.A. of the PPR motif (Mn) is isoleucine (I); (b) No. 9 A.A. of the PPR motif (Mn) is alanine (A); (c) No. 10 A.A. of the PPR motif (Mn) is tyrosine (Y); (d) No. 18 A.A. of the PPR motif (Mn) is lysine (K), arginine (R), or histidine (H); (e) No. 20 A.A. of the PPR motif (Mn) is glutamic acid (E), or aspartic acid (D); (f) No. 29 A.A. of the PPR motif (Mn) is glutamic acid (E), or aspartic acid (D); (g) No. 31 A.A.

Abstract: A method for producing an epithelial cell sheet, comprising culturing cells derived from oral mucosal epithelial cells on a substrate in a serum-free medium, wherein the serum-free medium comprises (i) EGF protein or KGF protein, (ii) B-27 supplement, and (iii) a ROCK inhibitor.

Abstract: The object of the present invention is to, by analyzing PPR proteins that act to bind to DNA with a prediction that RNA recognition rules of PPR motifs can also be used for recognition of DNA, find a PPR protein showing such a characteristic. According to the present invention, it was revealed that, with a protein that can bind in a DNA base-selective manner or a DNA base sequence-specific manner, which contains one or more, preferably 2 to 30, more preferably 5 to 25, most preferably 9 to 15, of PPR motifs having a structure of the following formula 1 (wherein, in the formula 1, Helix A is a part that can form an ?-helix structure; X does not exist, or is a part consisting of 1 to 9 amino acids; Helix B is a part that can form an ?-helix structure; and L is a part consisting of 2 to 7 amino acids), and having a specific combination of amino acids corresponding to a DNA base or DNA base sequence as amino acids of three positions of No. 1 A.A., No. 4 A.A., in Helix A of the formula 1 and No. “ii” (?2) A.A.

Abstract: The object of the present invention is to, by analyzing PPR proteins that act to bind to DNA with a prediction that RNA recognition rules of PPR motifs can also be used for recognition of DNA, find a PPR protein showing such a characteristic. According to the present invention, it was revealed that, with a protein that can bind in a DNA base-selective manner or a DNA base sequence-specific manner, which contains one or more, preferably 2 to 30, more preferably 5 to 25, most preferably 9 to 15, of PPR motifs having a structure of the following formula 1 (wherein, in the formula 1, Helix A is a part that can form an ?-helix structure; X does not exist, or is a part consisting of 1 to 9 amino acids; Helix B is a part that can form an ?-helix structure; and L is a part consisting of 2 to 7 amino acids), and having a specific combination of amino acids corresponding to a DNA base or DNA base sequence as amino acids of three positions of No. 1 A.A., No. 4 A.A., in Helix A of the formula 1 and No. “ii” (?2) A. A.

Abstract: A method of modifying the genome of an organism, wherein the modification method includes modifying the genome of the organism by using in a cell of the organism a protein having an optimal temperature for double-stranded DNA breakage activity in an ordinary temperature region.

Abstract: Provided is a silicon-based electro-optic modulator that exhibits an improved carrier plasma effect which is capable of realizing a low current density, low power consumption, a high modulation rate, low-voltage driving and high-speed modulation in a sub-micron region. The electro-optic modulator includes a waveguide structure including an Si or SiGe crystal. The electric field direction of light that propagates inside the waveguide structure is set to be approximately parallel with the <110> direction of the Si or SiGe crystal.

Abstract: A reinforcing member according to an aspect of the present disclosure is a long member provided between a frame and a frame on the rear side of a solar cell module. The reinforcing member is provided with: a pair of leg parts respectively fixed to inner flanges and of the frames and; a pair of wall parts erected on the respective leg parts and arranged roughly vertical to the rear surface of a solar cell panel; and a top board part that connects upper ends of the wall parts and are arranged along the rear surface in a state of being close to or in contact with the rear surface of the solar cell panel.

Abstract: A self-driving vehicle includes a plurality of operation members for the driver to operate and a controller. The plurality of operation members includes a steering operation member, a brake operation member, and an accelerating operation member. The controller has, as control modes thereof, an automatic operation mode and a manual operation mode. The operation member that is predefined as a trigger for the shift from the automatic operation mode to the manual operation mode differs depending on states of the vehicle in the automatic operation mode. The self-driving vehicle enables the driver to shift the control mode from the automatic operation mode to the manual operation mode with a simple operation.

Abstract: A method for designing a protein capable of binding in an RNA base selective manner or RNA base sequence specific manner is provided.

Abstract: A carrier includes a resin layer including Al and Sn and covering the surface of the carrier. A detectable amount of Al is from 1.0% to 12.1% by atom and a ratio (Al/Sn) of the detectable amount of Al to that of Sn is from 2.0 to 50.0 when the carrier is subjected to an X-ray photoelectron spectroscopic (XPS) analysis.

Abstract: A block has a planar portion abutting a back side of a contact region of a flexible substrate, and a recess that is concave with respect to the planar portion. An electronic component mounted on the flexible substrate is located within the recess. When viewed from a direction perpendicular to the planar portion, the recess is located at a position near a power supply bump, except at a position overlapping the power supply bump, or the recess is filled with a filler. The planar portion of the block abuts only the back side of the power supply bump.

Abstract: An operation estimation apparatus includes a distance measurement unit configured to measure a distance for a predetermined range, a human-body processing unit configured to detect a person on the basis of a distribution of measured distances, a tracking unit configured to assign an identifier to each detected person, and a situation estimation unit configured to estimate reaction of the person on the basis of a human data height which is a value of a height direction included in the measured distance in a first period set by prompting the person to start and end hand raising, wherein the situation estimation unit measures the human data height for each person to which the identifier is assigned a plurality of times in the first period, extracts an identifier for which human data heights are in the predetermined range, and estimates the reaction of the person corresponding to the extracted identifier.

Abstract: A method for designing a protein capable of binding in an RNA base selective manner or RNA base sequence specific manner is provided.

Abstract: A liquid level detector may include a float, an arm member, and a magnetic sensor unit. The float may be attached to the arm member. The arm member may be configured to convert a movement of the float in a vertical direction to a rotational movement. The magnetic sensor unit may include a magnetic sensor and covers. The covers may cover the magnetic sensor. The covers may include a first cover, and a second cover. The first cover may be made of a first resin material. The first cover may cover a whole surface of the magnetic sensor. The second cover may be made of a second resin material different from the first resin material. The second cover may cover a whole surface of the first cover.

Abstract: An evaporator which heats working fluid with high-temperature fluid to evaporate the working fluid includes: a working fluid channel arranged in a flow direction of the high temperature fluid and through which the working fluid flows; and a temperature sensor provided for the working fluid channel. A part of the working fluid channel is exposed to outside of a housing of the evaporator, and the temperature sensor is provided in the part of the working fluid channel exposed to the outside of the housing of the evaporator in a region other than an inlet of the working fluid channel into which the working fluid flows from the outside of the evaporator and other than an outlet of the working fluid channel through which the working fluid flows out of the evaporator. The output value of the temperature sensor is used to adjust the temperature of the working fluid.

Abstract: An evaporator which heats working fluid with high-temperature fluid to evaporate the working fluid includes: a working fluid channel which is arranged in a flow direction of the high temperature fluid and through which the working fluid flows; and a temperature sensor which is provided for the working fluid channel. A part of the working fluid channel is exposed to outside of a housing of the evaporator, and the temperature sensor is provided in the part of the working fluid channel exposed to the outside of the housing of the evaporator in a region other than an inlet of the working fluid channel into which the working fluid flows from the outside of the evaporator and other than an outlet of the working fluid channel through which the working fluid flows out of the evaporator. The output value of the temperature sensor is used to adjust the temperature of the working fluid in the evaporator.

Abstract: A coil spring modeling apparatus includes a first attachment member disposed on a lower spring seat, a second attachment member disposed on an upper spring seat, an actuator unit formed of a Stewart-platform-type parallel mechanism, a hydraulic pressure supply device, a torsion detection mechanism, and a controller. The torsion detection mechanism is constituted of displacement gauges such as a linear variable differential transformer. The displacement gauges are provided on hydraulic cylinders, and detect amounts of displacement relative to the reference lengths of the hydraulic cylinders, respectively. The controller calculates a relative torsional angle between the first attachment member and the second attachment member based on the detected displacement.

Abstract: A coil spring modeling apparatus includes a first attachment member disposed on a lower spring seat, a second attachment member disposed on an upper spring seat, an actuator unit formed of a Stewart-platform-type parallel mechanism, a spring height detection mechanism, and a controller. The spring height detection mechanism is constituted of displacement gauges such as a linear variable differential transformer. These gauges are provided on hydraulic cylinders, and detect amounts of displacement relative to the reference lengths of the hydraulic cylinders, respectively. A hydraulic pressure supply device is controlled by the controller and supplies fluid pressure according to the displacement detected by the gauges to the respective hydraulic cylinders.