Patents by Inventor Takahiro Shikayama
Takahiro Shikayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240082834Abstract: A biological sample holding container includes: a container main body having a bottom surface portion having a placement region for a biological sample and a side surface portion provided on the bottom surface portion so as to surround the placement region; and an annular holding member insertable and removable inside the side surface portion. The holding member holds a film covering the biological sample on the placement region with the bottom surface portion by being inserted inside the side surface portion together with the film.Type: ApplicationFiled: July 16, 2020Publication date: March 14, 2024Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Kazumasa HIRAWAKE, Takahiro MURAKOSHI, Takahiro SHIKAYAMA, Takayuki SATO
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Patent number: 11921043Abstract: A fluorescence observation device is a device for performing fluorescence observation of a sample piece cut out from a sample including: a tray on which the sample piece is placed; a light source unit which generates excitation light to irradiate the sample piece; a detection unit which detects fluorescence from the sample piece; and an image generation unit which generates a fluorescence image of the sample piece based on a detection signal from the detection unit and the tray includes a plurality of placement regions provided around a center region of the tray and also includes a marker portion indicating a cutting orientation of the sample piece with respect to the sample.Type: GrantFiled: December 2, 2019Date of Patent: March 5, 2024Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Kazumasa Hirawake, Takahiro Murakoshi, Takahiro Shikayama, Takayuki Sato
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Publication number: 20220170858Abstract: A fluorescence observation device is a device for performing fluorescence observation of a sample piece cut out from a sample including: a tray on which the sample piece is placed; a light source unit which generates excitation light to irradiate the sample piece; a detection unit which detects fluorescence from the sample piece; and an image generation unit which generates a fluorescence image of the sample piece based on a detection signal from the detection unit and the tray includes a plurality of placement regions provided around a center region of the tray and also includes a marker portion indicating a cutting orientation of the sample piece with respect to the sample.Type: ApplicationFiled: December 2, 2019Publication date: June 2, 2022Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Kazumasa HIRAWAKE, Takahiro MURAKOSHI, Takahiro SHIKAYAMA, Takayuki SATO
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Patent number: 11246948Abstract: An embodiment relates to a method of evaluating a lymphatic system function including: selecting one or a plurality of lymphatic routes to be evaluated from a plurality of lymphatic routes existing in four limbs; determining an injection site of a visualization agent based on information on the selected lymphatic route and injection sites of peripheries of the four limbs corresponding to the selected lymphatic route; injecting the visualization agent from the selected injection site; and visualizing the injected visualization agent and evaluating functions of the one or plurality of lymphatic routes to be evaluated.Type: GrantFiled: December 31, 2018Date of Patent: February 15, 2022Assignees: National University Corporation Okayama University, HAMAMATSU PHOTONICS K.K.Inventors: Akira Shinaoka, Yoshihiro Kimata, Aiji Ohtsuka, Takahiro Shikayama
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Publication number: 20190201555Abstract: An embodiment relates to a method of evaluating a lymphatic system function including: selecting one or a plurality of lymphatic routes to be evaluated from a plurality of lymphatic routes existing in four limbs; determining an injection site of a visualization agent based on information on the selected lymphatic route and injection sites of peripheries of the four limbs corresponding to the selected lymphatic route; injecting the visualization agent from the selected injection site; and visualizing the injected visualization agent and evaluating functions of the one or plurality of lymphatic routes to be evaluated.Type: ApplicationFiled: December 31, 2018Publication date: July 4, 2019Applicants: National University Corporation Okayama University, HAMAMATSU PHOTONICS K.K.Inventors: Akira SHINAOKA, Yoshihiro KIMATA, Aiji OHTSUKA, Takahiro SHIKAYAMA
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Publication number: 20190113455Abstract: A fluorescence observation method includes a fluorescence imaging step of imaging fluorescence from an observation target by an imaging portion. The fluorescence imaging step includes a darkening step of darkening a space between the observation target and an observation window of the imaging portion by pressing a tip end portion of a light shielding member to the observation target or a placement surface of the observation target, in a state where a base end portion of the light shielding member including a tubular main body portion is attached to the imaging portion to surround the observation window, and a focus adjustment step of adjusting a focus position of the imaging portion.Type: ApplicationFiled: March 23, 2017Publication date: April 18, 2019Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Mitsuharu MIWA, Takahiro SHIKAYAMA
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Patent number: 10041831Abstract: The fluorescent light phantom device 1 is provided with: a phantom support 10 having fluorescent light phantom containers 1b, 1c, 1d and 1e; and fluorescent light phantoms 12, 13, 14 and 15 which are constituted of a medium that reproduces at least one of light scattering and light absorption of an object to be measured and a fluorescent coloring matter contained in the medium of a predetermined concentration and are stored in the fluorescent light phantom containers 1b, 1c, 1d and 1e.Type: GrantFiled: October 18, 2012Date of Patent: August 7, 2018Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Kenjiro Hasegawa, Mitsuharu Miwa, Takahiro Shikayama
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Patent number: 9717806Abstract: A method of detecting an accessory cancer lesion, comprising an administration step wherein indocyanine green is administered to a living body, an irradiation step wherein a target organ suspected of having cancer is surgically exposed and irradiated with excitation light of indocyanine green, an imaging step wherein a near-infrared fluorescence intensity distribution image from the excited indocyanine green in the target organ is obtained, and an identification step wherein an area having the near-infrared fluorescence in the intensity distribution image, excluding the area detected in preoperative examination or intraoperative macroscopic observation, is identified as an accessory cancer lesion.Type: GrantFiled: December 19, 2014Date of Patent: August 1, 2017Assignees: OSAKA PREFECTURAL HOSPITAL ORGANIZATION, HAMAMATSU PHOTONICS K.K.Inventors: Osamu Ishikawa, Terumasa Yamada, Kunihito Gotoh, Mitsuharu Miwa, Takahiro Shikayama
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Publication number: 20150104396Abstract: A method of detecting an accessory cancer lesion, comprising an administration step wherein indocyanine green is administered to a living body, an irradiation step wherein a target organ suspected of having cancer is surgically exposed and irradiated with excitation light of indocyanine green, an imaging step wherein a near-infrared fluorescence intensity distribution image from the excited indocyanine green in the target organ is obtained, and an identification step wherein an area having the near-infrared fluorescence in the intensity distribution image, excluding the area detected in preoperative examination or intraoperative macroscopic observation, is identified as an accessory cancer lesion.Type: ApplicationFiled: December 19, 2014Publication date: April 16, 2015Inventors: Osamu Ishikawa, Terumasa Yamada, Kunihito GOTOH, Mitsuharu Miwa, Takahiro Shikayama
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Patent number: 8956591Abstract: A method of detecting an accessory cancer lesion, comprising an administration step wherein indocyanine green is administered to a living body, an irradiation step wherein a target organ suspected of having cancer is surgically exposed and irradiated with excitation light of indocyanine green, an imaging step wherein a near-infrared fluorescence intensity distribution image from the excited indocyanine green in the target organ is obtained, and an identification step wherein an area having the near-infrared fluorescence in the intensity distribution image, excluding the area detected in preoperative examination or intraoperative macroscopic observation, is identified as an accessory cancer lesion.Type: GrantFiled: May 14, 2009Date of Patent: February 17, 2015Assignees: Osaka Prefectural Hospital Organization, Hamamatsu Photonics K.K.Inventors: Osamu Ishikawa, Terumasa Yamada, Kunihito Gotoh, Mitsuharu Miwa, Takahiro Shikayama
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Publication number: 20140303496Abstract: The fluorescent light phantom device 1 is provided with: a phantom support 10 having fluorescent light phantom containers 1b, 1c, 1d and 1e; and fluorescent light phantoms 12, 13, 14 and 15 which are constituted of a medium that reproduces at least one of light scattering and light absorption of an object to be measured and a fluorescent coloring matter contained in the medium of a predetermined concentration and are stored in the fluorescent light phantom containers 1b, 1c, 1d and 1e.Type: ApplicationFiled: October 18, 2012Publication date: October 9, 2014Inventors: Kenjiro Hasegawa, Mitsuharu Miwa, Takahiro Shikayama
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Patent number: 8190231Abstract: A sentinel lymph node detecting apparatus 1 includes: an excitation light source unit 2 that illuminates an excitation light 10 onto a living body observation portion 20 including a sentinel lymph node 21 near a tumor into which a fluorescent dye that emits fluorescence is injected; an optical filter 3 that transmits a fluorescence image 11; an image pickup device 4 that is integral with excitation light source unit 2 and picks up fluorescence image 11 transmitted through optical filter 3; an adjusting device 5 that adjusts the picked-up observation image; and an image displaying device 6 that displays the adjusted observation image. Adjusting device 5 adjusts at least one of a luminance and a contrast of the observation image. A lymph node detecting apparatus that is simple in apparatus arrangement, is easy to handle, and enables good images to be obtained is thereby realized.Type: GrantFiled: November 16, 2004Date of Patent: May 29, 2012Assignee: Hamamatsu Photonics K.K.Inventors: Mitsuharu Miwa, Takahiro Shikayama, Toshiyuki Kitai
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Patent number: 8046055Abstract: A sentinel lymph node detecting apparatus 1 according to an embodiment of the present invention includes: a light source unit 2, illuminating an excitation light 10 and an illumination light 11 onto a biological observation location 20 that includes a sentinel lymph node 21 near a tumor, into which a fluorescent dye that emits fluorescence is injected; an optical filter 3, transmitting a fluorescence image 11 and a normal image 13; an image pickup device 5, disposed integral to the light source unit 2 and picking up the fluorescence image 11 and the normal image 13 transmitted through the optical filter 3; and an image display device 7, displaying the observation images that have been picked up. The wavelength of the illumination light 11 is set to a value close to the wavelength of the fluorescence emitted from the fluorescent dye.Type: GrantFiled: May 25, 2005Date of Patent: October 25, 2011Assignee: Hamamatsu Photonics K.K.Inventors: Mitsuharu Miwa, Takahiro Shikayama
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Patent number: D822208Type: GrantFiled: September 14, 2016Date of Patent: July 3, 2018Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Takahiro Shikayama, Mitsuharu Miwa
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Patent number: D822209Type: GrantFiled: September 14, 2016Date of Patent: July 3, 2018Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Mitsuharu Miwa, Takahiro Shikayama
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Patent number: D864395Type: GrantFiled: June 8, 2018Date of Patent: October 22, 2019Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Takahiro Shikayama, Mitsuharu Miwa
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Patent number: D874652Type: GrantFiled: June 4, 2018Date of Patent: February 4, 2020Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Mitsuharu Miwa, Takahiro Shikayama
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Patent number: D879962Type: GrantFiled: June 4, 2018Date of Patent: March 31, 2020Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Mitsuharu Miwa, Takahiro Shikayama
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Patent number: D880698Type: GrantFiled: June 4, 2018Date of Patent: April 7, 2020Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Mitsuharu Miwa, Takahiro Shikayama
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Patent number: D919813Type: GrantFiled: March 6, 2020Date of Patent: May 18, 2021Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Mitsuharu Miwa, Takahiro Shikayama