Abstract: The invention relates to a non-human knockin animal having a mutation in a proBDNF gene wherein conversion from proBDNF to BDNF has been inhibited by the mutation.

Abstract: The present invention provides a compartment-arrayed probe for measuring extracellular electrical potential, the probe comprising: a compartment body (1) having a plurality of through-holes; and an electrode substrate (2) composed of a non-electrically conductive material, on one surface of which the plurality of measurement electrodes are disposed and a tubular member (3) is disposed in such a manner as to surround the measurement electrodes; wherein one surface of the compartment body (1) to which each of the through-holes opens is adhered to an area surrounded by the tubular member (3) on the electrode substrate (2) in such a manner that at least a part of the plurality of through-holes surround a part of the plurality of measurement electrodes; a part of an inner wall surface of the through-hole contacts a culture medium when it is injected thereinto; the part of the inner wall surface is composed of an electrically conductive material; and the electrical potential of the measurement electrode is measured

Abstract: A method for fixing, on a substrate, functional material such as proteins, enzymes, polysaccharides, nucleic acids, microorganisms, viruses and cultured cells, includes the steps of (i) forming on the substrate a photosensitive layer containing DNQ, novolak, and optionally imidazole; (ii) applying onto the substrate functional material containing at least one amino group; (iii) before or after step (ii), irradiating in a pattern the photosensitive layer with light of appropriate wavelength(s) to convert DNQ to a ketene compound; and (iv) reacting the amino group with the ketene compound to fix via amido bonding the functional material to the substrate via the photosensitive layer along the pattern.