Patents by Inventor Takaji Honna
Takaji Honna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5447944Abstract: The present invention provides carbamoyl-2 -pyrrolidinone compounds useful as medicaments for improving cerebral functions and activating cerebral metabolism or protecting against anoxic brain damage.Type: GrantFiled: March 22, 1994Date of Patent: September 5, 1995Assignee: Taiho Pharmaceutical Company, LimitedInventors: Makoto Kajitani, Etsuo Hasegawa, Akihiro Kawaguchi, Junji Yamamoto, Katsuo Toide, Takaji Honna, Mitsugi Yasumoto, Nobuo Kasahara
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Patent number: 5229402Abstract: The present invention provides a carbamoyl-2-pyrrolidinone compound which has the following formula (2) and is useful as medicaments for treating senile dementia, i.e., as cerebral function improving agents and cerebral metabolism activators or anoxic brain damage protectives ##STR1## wherein R.sup.1 is a hydrogen atom, hydroxyl or lower alkyl substituted or unsubstituted with hydroxyl, and R.sup.3 is phenyl, tetrahydronaphthyl, pyridyl or thiazolyl having or not having lower alkoxyl, lower alkylamino, a halogen atom or halogenomethyl as a substituent.Further, the present invention provides novel carbamoyl-2-pyrrolidinone compounds represented by the formula ##STR2## wherein R.sup.1 is a hydrogen atom, hydroxyl or lower alkyl substituted or unsubstituted with hydroxyl, and R.sup.2 is phenyl, tetrahydronaphthyl, pyridyl or thiazolyl having or not having methoxy or lower alkylamino as a substituent, provided that when R.sup.1 is a hydrogen atom or unsubstituted lower alkyl, R.sup.2 is not unsubstituted phenyl.Type: GrantFiled: December 13, 1989Date of Patent: July 20, 1993Assignee: Taiho Pharmaceutical Company, Ltd.Inventors: Makoto Kajitani, Etsuo Hasegawa, Akihiro Kawaguchi, Junji Yamamoto, Katsuo Toide, Takaji Honna, Mitsugi Yasumoto, Nobuo Kasahara
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Patent number: 4777259Abstract: Disclosed are a compound of the formula ##STR1## wherein R.sub.1 is lower alkyl, A is a group of the formula ##STR2## (in which R.sub.3 is hydrogen or lower alkyl) or methylene, and R.sub.2 is hydrogen or a group of the formula --(CH.sub.2).sub.n COOH (in which n is an integer of 1 to 6) or a salt of the derivative, and preparation thereof. The compounds have an excellent aldose reductase inhibitory action.Type: GrantFiled: April 27, 1987Date of Patent: October 11, 1988Assignee: Taiho Pharmaceutical Company LimitedInventors: Kazuo Ogawa, Takaji Honna
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Patent number: 4714765Abstract: Disclosed are a compound of the formula ##STR1## wherein R.sub.1 is lower alkyl, A is a group of the formula ##STR2## (in which R.sub.3 is hydrogen or lower alkyl) or methylene, and R.sub.2 is hydrogen or a group of the formula --(CH.sub.2).sub.n COOH (in which n is an integer of 1 to 6) or a salt of the derivative, and preparation thereof. The compounds have an excellent aldose reductase inhibitory action.Type: GrantFiled: December 19, 1985Date of Patent: December 22, 1987Assignee: Taiho Pharmaceutical Company, LimitedInventors: Kazuo Ogawa, Takaji Honna
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Patent number: 4696929Abstract: A piperazine derivative represented by the formula (I) below ##STR1## wherein R.sup.1 is lower alkyl or phenyl, R.sup.2 is hydrogen or lower alkyl, n is an integer of 2 to 10, is useful as an effective component of anti-inflammatory agent or antiallergic agent.Type: GrantFiled: December 17, 1985Date of Patent: September 29, 1987Assignee: Taiho Pharmaceutical Company, LimitedInventors: Ichiro Yamawaki, Kazuo Ogawa, Naohiko Ono, Takaji Honna, Sekio Nagayama, Mitsugi Yasumoto
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Patent number: 4666911Abstract: An analgesic compositon containing as active ingredient an allophanoylpiperazine compound represented by the general formula ##STR1## wherein R.sup.1 represents a lower alkyl group or phenyl group; R.sup.2 and R.sup.3 each represents a hydrogen atom or a lower alkyl group; and R.sup.4 represents a phenyl group or a substituted phenyl group having as substituent a halogen atom or methyl, trifluoromethyl, hydroxyl, methoxy, methylenedioxy, nitro, or carboxyl group; pyridyl group, pyrimidyl group, thiazolyl group, benzyl group, cinnamyl group, cyclohexyl group, a lower alkyl group, a substituted lower alkyl group having chlorine atom or hydroxyl group as substituent; or a lower alkenyl group.Type: GrantFiled: July 8, 1981Date of Patent: May 19, 1987Assignee: Taiho Pharmaceutical Company LimitedInventors: Hajime Fujimura, Yasuzo Hiramatu, Takahiro Yabuuchi, Masakatu Hisaki, Katsuo Takikawa, Takaji Honna, Hidekazu Miyake, Makoto Kajitani
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Patent number: 4518712Abstract: An analgesic composition containing as active ingredient a piperazine derivative represented by the general formula (1) ##STR1## wherein R.sub.1 represents a cyclopropylmethyl group, an isopropyl group or an allyl group and R.sub.2 represents a phenyl group having as substituent a halogen atom or a trifluoromethyl group.Type: GrantFiled: June 22, 1981Date of Patent: May 21, 1985Assignee: Taiho Pharmaceutical Company LimitedInventors: Hajime Fujimura, Yasuzo Hiramatsu, Tomio Yamazaki, Shozo Yamada, Takaji Honna
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Patent number: 4371544Abstract: An analgesic, anti-inflammatory or anti-pyretic composition containing 1,1,3,5-substituted biuret compound of the formula, ##STR1## wherein R.sup.1 is a lower alkyl group or a phenyl group; R.sup.2 is a lower alkyl group, a phenyl group or a substituted phenyl group having chlorine atom(s), methyl group(s) or methoxy group(s) as the substituent(s), further R.sup.1 and R.sup.2 may form a single ring containing one or two hetero atoms including the adjacent nitrogen atom; R.sup.3 is a hydrogen atom, a lower alkyl group or a phenyl group; R.sup.4 is a phenyl group, a substituted phenyl group having halogen atom(s), trifluoromethyl group(s), methyl group(s), methoxy group(s), dimethyl-amino group(s), nitro group(s), hydroxyl group(s), acetyl group(s), or methylthio group(s) as the substituent(s), a benzyl group, a cyclohexyl group or a lower alkyl group, as the active ingredient.Type: GrantFiled: April 24, 1981Date of Patent: February 1, 1983Assignee: Taiho Pharmaceutical Company LimitedInventors: Hajime Fujimura, Yasuzo Hiramatsu, Takahiro Yabuuchi, Masakatu Hisaki, Katsuo Takikawa, Takaji Honna, Hidekazu Miyake, Makoto Kajitani
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Patent number: 4350700Abstract: An analgesic, anti-inflammatory or anti-pyretic composition containing 1,3,5-substituted biuret compound of the formula, ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a substituted lower alkyl group having chlorine atom(s), cyano group(s), dimethylamino group(s), hydroxy group(s), methoxy group(s) or carboxy group(s) as the substituent(s), a lower alkenyl group, a hydroxy group, a methoxy group, an acetyl group or a phenyl group; R.sup.2 is a hydrogen atom, a lower alkyl group or a phenyl group; R.sup.3 is a phenyl group, a substituted phenyl group having halogen atom(s), trifluoromethyl group(s), methyl group(s), methoxy group(s), methylenedioxy group(s), hydroxy group(s), dimethylamino group(s), carboxy group(s) or carboxymethyl group(s) as the substituent(s), a benzyl group, a pyridyl group, a substituted pyridyl group having methyl group(s) as the substituent(s), a pyridylmethyl group, pyrimidinyl group, a thiazolyl group or a thienyl group, as the active ingredient.Type: GrantFiled: April 27, 1981Date of Patent: September 21, 1982Assignee: Taiho Pharmaceutical Company, LimitedInventors: Hajime Fujimura, Yasuzo Hiramatsu, Takahiro Yabuuchi, Masakatu Hisaki, Katsuo Takikawa, Takaji Honna, Hidekazu Miyake, Makoto Kajitani
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Patent number: 4293713Abstract: A novel 1,1,3,5-substituted biuret compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are respectively the same or different, and each are alkyl groups having 1 to 4 carbon atoms; R.sup.3 is a cyclohexyl group or a phenyl group which may be unsubstituted or may have at least one substituent selected from the group consisting of chlorine, bromine, fluorine, methyl, trifluoromethyl, dimethylamino, methoxy, methylthio, nitro and acetyl. The novel 1,1,3,5-substituted biuret compounds are useful as an analgesic, anti-inflammatory and/or anti-pyretic agent.Type: GrantFiled: March 27, 1980Date of Patent: October 6, 1981Assignee: Taiho Pharmaceutical Company LimitedInventors: Hajime Fujimura, Yasuzo Hiramatsu, Takahiro Yabuuchi, Masakatu Hisaki, Katsuo Takikawa, Takaji Honna, Hidekazu Miyake, Makoto Kajitani
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Patent number: 4287207Abstract: An analgesic, anti-inflammatory or anti-pyretic composition containing 1,3,5-substituted biuret compound of the formula, ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a substituted lower alkyl group having chlorine atom(s), cyano group(s), dimethylamino group(s), hydroxy group(s), methoxy group(s) or carboxy group(s) as the substituent(s), a lower alkenyl group, a hydroxy group, a methoxy group, an acetyl group or a phenyl group; R.sup.2 is a hydrogen atom, a lower alkyl group or a phenyl group; R.sup.3 is a phenyl group, a substituted phenyl group having halogen atom(s), trifluoromethyl group(s), methyl group(s), methoxy group(s), methylenedioxy group(s), hydroxy group(s), dimethylamino group(s), carboxy group(s) or carboxymethyl group(s) as the substituent(s), a benzyl group, a pyridyl group, a substituted pyridyl group having methyl group(s) as the substituent(s), a pyridylmethyl group, pyrimidinyl group, a thiazolyl group or a thienyl group, as the active ingredient.Type: GrantFiled: March 27, 1980Date of Patent: September 1, 1981Assignee: Taiho Pharmaceutical Company, LimitedInventors: Hajime Fujmura, Yasuzo Hiramatsu, Takahiro Yabuuchi, Masakatu Hisaki, Katsuo Takikawa, Takaji Honna, Hidekazu Miyake, Makoto Kajitani
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Patent number: 4278672Abstract: An analgesic, anti-inflammatory or anti-pyretic composition containing 1,1,3,5-substituted biuret compound of the formula, ##STR1## wherein R.sup.1 is a lower alkyl group or a phenyl group; R.sup.2 is a lower alkyl group, a phenyl group or a substituted phenyl group having chlorine atom(s), methyl group(s) or methoxy group(s) as the substituent(s), further R.sup.1 and R.sup.2 may form a single ring containing one or two hetero atoms including the adjacent nitrogen atom; R.sup.3 is a hydrogen atom, a lower alkyl group or a phenyl group; R.sup.4 is a phenyl group, a substituted phenyl group having halogen atom(s), trifluoromethyl group(s), methyl group(s), methoxy group(s), dimethylamino group(s), nitro group(s), hydroxyl group(s), acetyl group(s) or methylthio group(s) as the substituent(s), a benzyl group, a cyclohexyl group or a lower alkyl group, as the active ingredient.Type: GrantFiled: March 27, 1980Date of Patent: July 14, 1981Assignee: Taiho Pharmaceutical Company, LimitedInventors: Hajime Fujimura, Yasuzo Hiramatsu, Takahiro Yabuuchi, Masakatu Hisaki, Katsuo Takikawa, Takaji Honna, Hidekazu Miyake, Makoto Kajitani
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Patent number: 4243812Abstract: Novel derivatives of glyoxal-2-oxim represented by the chemical formula ##STR1## wherein R is hydrogen or a lower alkyl or phenyl group, are provided in accordance with the present invention. These derivatives are prepared by reacting the corresponding isoxazole-5-carbaldehyde with nitromethane in the presence of a metal alkoxide, or the corresponding 5-acetylisoxazole with a nitrate. They have anti-inflammatory and/or analgesic activities.Type: GrantFiled: August 20, 1979Date of Patent: January 6, 1981Assignee: Taiho Pharmaceutical CompanyInventors: Takaji Honna, Motoaki Tanaka, Syozo Yamada, Hidekazu Miyake
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Patent number: 4224450Abstract: Novel derivatives of glyoxal-2-oxim represented by the chemical formula ##STR1## wherein R is hydrogen or a lower alkyl or phenyl group, are provided in accordance with the present invention. These derivatives are prepared by reacting the corresponding isoxazole-5-carbaldehyde with nitromethane in the presence of a metal alkoxide, or the corresponding 5-acetylisoxazole with a nitrite. They have anti-inflammatory and/or analgesic activities.Type: GrantFiled: August 20, 1979Date of Patent: September 23, 1980Assignee: Taiho Pharmaceutical CompanyInventors: Takaji Honna, Motoaki Tanaka, Syozo Yamada, Hidekazu Miyake
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Patent number: 4212874Abstract: Novel derivatives of glyoxal-2-oxim represented by the chemical formula ##STR1## wherein R is hydrogen or a lower alkyl or phenyl group, are provided in accordance with the present invention. These derivatives are prepared by reacting the corresponding isoxazole-5-carbaldehyde with nitromethane in the presence of a metal alkoxide, or the corresponding 5-acetylisoxazole with a nitrite. They have anti-inflammatory and/or analgesic activities.Type: GrantFiled: March 2, 1979Date of Patent: July 15, 1980Assignee: Taiho Pharmaceutical Company, LimitedInventors: Takaji Honna, Motoaki Tanaka, Syozo Yamada, Hidekazu Miyake