Patents by Inventor Takako Kawabe

Takako Kawabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Estradiol derivative-alkylating agent conjugate with reduced hormonal activity, process for preparing the same, compounds useful for the preparation thereof, and growth inhibiting compositon containing the conjugate or estradiol derivative.
    Patent number: 5633393
    Abstract: Conjugates of the formula ##STR1## are prepared by reacting an estradiol derivative with a compound of the formula: ##STR2## in the presence of thionyl chloride or a metal hydride at -30.degree. to 150.degree. C. for 3 minutes to 48 hours and then recovering and purifying the product.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: May 27, 1997
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Koichi Niimura, Takako Kawabe, Tsutomu Wada, Tsuyoshi Saitoh, Kenji Bannai
  • Estradiol derivative and growth inhibiting composition thereof
    Patent number: 5561125
    Abstract: Estradiol derivatives of the formula: ##STR1## wherein R.sup.1 is C.sub.1-4 alky or C.sub.1-4 alkoxy; R.sup.2 is acyl or benzyl; m is an integer of 1 to 3; n is an integer of 1 to 3; and X is hydroxy or halogen are useful as tumor growth inhibiting agents.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: October 1, 1996
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Koichi Niimura, Takako Kawabe, Tsutomu Wada, Tsuyoshi Saitoh, Kenji Bannai
  • Estradiol derivative alkylating agent conjugate with reduced hormonal activity, process for preparing the same, compounds useful for the preparation thereof, and growth inhibiting composition containing the conjugate or estradiol derivative
    Patent number: 5491138
    Abstract: Disclosed is a method of inhibiting the growth of tumors by administering an estradiol derivative-alkylating agent conjugate of the formula (I'): ##STR1## wherein R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy; R.sup.2 is acyl or benzyl; m is an integer of 1 to 3; and n is an integer of 0 to 3. Also disclosed is a method of inhibiting the growth of tumors by administering a compound of the formula (II); ##STR2## wherein R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy; R.sup.2 is acyl or benzyl; m is an integer of 1 to 3; n is an integer of 0 to 3; and X is hydroxy or halogen.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: February 13, 1996
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Koichi Niimura, Takako Kawabe, Tsutomu Wada, Tsuyoshi Saitoh, Kenji Bannai
  • Method for treating prostatic hypertrophy with estradiol derivatives
    Patent number: 5480878
    Abstract: Disclosed is a method for treating prostatic hypertrophy with an estradiol derivative-alkylating agent conjugate of the formula (1'): ##STR1## wherein R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy; R.sup.2 is acyl or benzyl; m is an integer of 1 to 3; and n is an integer of 0 to 3. Also disclosed is the treatment of prostatic hypertrophy with an estradiol derivative of the formula (II): ##STR2## wherein R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy; R.sup.2 is acyl or benzyl; m is an integer of 1 to 3; and n is an integer of 0 to 3; and X is hydroxy or halogen.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: January 2, 1996
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Koichi Niimura, Takako Kawabe, Tsutomu Wada, Tsuyoshi Saitoh, Kenji Bannai
  • Estradiol derivative-alkylating agent conjugate with reduced hormonal activity, process for preparing the same, compounds useful for the preparation thereof, and growth inhibiting composition containing the conjugate or estradiol derivative
    Patent number: 5478818
    Abstract: Disclosed is an estradiol derivative-alkylating agent conjugate of the formula (I'): ##STR1## wherein R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy; R.sup.2 is acyl or benzyl; m is an integer of 1 to 3; and n is an integer of 0 to 3, which is useful a growth inhibiting agent.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: December 26, 1995
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Koichi Niimura, Takako Kawabe, Tsutomu Wada, Tsuyoshi Saitoh, Kenji Bannai
  • Phenylalanine-glycine derivatives, process for preparation thereof, and pharmaceutical composition containing said derivatives
    Patent number: 5470960
    Abstract: A phenylalanine-glycine derivative of the general formula (I): ##STR1## wherein R represents a residue of an antitumor substance, or a salt or ester thereof, a process for preparation thereof, and a pharmaceutical composition containing the same are described.The novel conjugate of the phenylalanine-glycine derivative and the antitumor substance exhibits superior antitumor activity in comparison with the case wherein an antitumor substance is administered singly or as a mixture with phenylalanine.
    Type: Grant
    Filed: January 11, 1995
    Date of Patent: November 28, 1995
    Assignee: Kureha Chemical Industry Co., Ltd.
    Inventors: Koichi Niimura, Takako Kawabe, Takao Ando, Kenichi Saito
  • Phenylalanine-glycine compounds having anti-tumor activity, process for preparation thereof, and pharmaceutical composition containing said compounds
    Patent number: 5411964
    Abstract: A phenylalanine-glycine compound of formula (I): ##STR1## wherein R represents a residue of an antitumor substance, or a salt or ester thereof, a process for preparation thereof, and a pharmaceutical composition containing the same are described. The novel conjugate of the phenylalanine-glycine compound and the antitumor substance exhibits superior antitumor activity in comparison with the case wherein an antitumor substance is administered alone or as a mixture with phenylalanine.
    Type: Grant
    Filed: March 15, 1993
    Date of Patent: May 2, 1995
    Assignee: Kureha Chemical Industry Co., Ltd.
    Inventors: Koichi Niimura, Takako Kawabe, Takao Ando, Kenichi Saito