Patents by Inventor Takako Niwa

Takako Niwa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240269255
    Abstract: Provided are lipid particles encapsulating a nucleic acid capable of expressing an E6 antigen and an E7 antigen of human papillomavirus, whereby a vaccine for preventing and/or treating infection with human papillomavirus type 6 and/or type 11 can be provided. The lipid particles comprise a lipid that is a cationic lipid having the general formula (Ia), or a pharmaceutically acceptable salt thereof. [In the formula, R1, R2, p, L1 and L2 are as defined in the specification.
    Type: Application
    Filed: May 18, 2022
    Publication date: August 15, 2024
    Inventors: Yoshikuni ONODERA, Sumika TANOUE, Takako NIWA, Makoto KOIZUMI
  • Publication number: 20240238404
    Abstract: Provided is a vaccine for preventing and/or treating an infection with an influenza virus. The vaccine comprises lipid particles containing a nucleic acid capable of expressing a haemagglutinin (HA) protein of the influenza virus, wherein a lipid is a cationic lipid having general formula (Ia), or a pharmaceutically acceptable salt thereof. [In the formula, R1, R2, p, L1 and L2 are as defined in the specification.
    Type: Application
    Filed: May 18, 2022
    Publication date: July 18, 2024
    Inventors: Takanori TOMOZAWA, Takako NIWA, Yukinobu NUMATA, Makoto KOIZUMI
  • Publication number: 20240238407
    Abstract: Provided is a vaccine for preventing and/or treating infection with human T-cell leukemia virus type 1 (HTLV-1). A lipid particle encapsulating a nucleic acid expressing a gp46 antigen or a Tax antigen of human T-cell leukemia virus type 1 (HTLV-1), wherein the lipid comprises a cationic lipid represented by general formula (Ia): or a pharmaceutically acceptable salt thereof, wherein R1 and R2 each independently represent a C1-C3 alkyl group; L1 represents a C17-C19 alkenyl group optionally having one or more C2-C4 alkanoyloxy groups; L2 represents a C10-C19 alkyl group optionally having one or more C2-C4 alkanoyloxy groups, or a C10-C19 alkenyl group optionally having one or more C2-C4 alkanoyloxy groups; and p is 3 or 4.
    Type: Application
    Filed: May 18, 2022
    Publication date: July 18, 2024
    Inventors: Ken ISHII, Takuya FUKUSHIMA, Yuetsu TANAKA, Fumihiko TAKESHITA, Makoto KOIZUMI, Takako NIWA, Shoko NOGUSA, Nao JONAI, Yoshikuni ONODERA
  • Publication number: 20230248819
    Abstract: The present invention provides a vaccine for preventing and/or treating infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The present invention relates to a lipid particle encapsulating a nucleic acid molecule capable of expressing the S protein and/or a fragment thereof of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), wherein the lipid comprises a cationic lipid represented by general formula (Ia) or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each independently represent a C1-C3 alkyl group; L1 represents a C17-C19 alkenyl group which may have one or a plurality of C2-C4 alkanoyloxy groups; L2 represents a C10-C19 alkyl group which may have one or a plurality of C2-C4 alkanoyloxy groups or a C10-C19 alkenyl group which may have one or a plurality of C2-C4 alkanoyloxy groups; and p is 3 or 4.
    Type: Application
    Filed: June 10, 2021
    Publication date: August 10, 2023
    Inventors: Yoshihiro KAWAOKA, Masaki IMAI, Seiya YAMAYOSHI, Ken ISHII, Kouji KOBIYAMA, Eiko NAMBA, Tatsuya OKA, Miyuki TOZUKA, Nao JONAI, Yoshikuni ONODERA, Fumihiko TAKESHITA, Takashi SUZUKI, Takako NIWA, Makoto KOIZUMI, Kensuke NAKAMURA
  • Publication number: 20220409540
    Abstract: The present invention provides a vaccine for preventing and/or treating infections with human papillomavirus. The present invention relates to a lipid particle encapsulating a nucleic acid molecule capable of expressing the E6 and E7 antigens of human papillomavirus, wherein the lipid comprises a cationic lipid represented by general formula (Ia) or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each independently represent a C1-C3 alkyl group; L1 represents a C17-C19 alkenyl group which may have one or a plurality of C2-C4 alkanoyloxy groups; L2 represents a C10-C19 alkyl group which may have one or a plurality of C2-C4 alkanoyloxy groups or a C10-C19 alkenyl group which may have one or a plurality of C2-C4 alkanoyloxy groups; and p is 3 or 4.
    Type: Application
    Filed: November 13, 2020
    Publication date: December 29, 2022
    Inventors: Takako NIWA, Takashi SUZUKI, Makoto KOIZUMI, Nao JONAI, Yoshikuni ONODERA, Fumihiko TAKESHITA, Ken ISHII
  • Patent number: 11015202
    Abstract: The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3?-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and ?-1,3-glucan.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: May 25, 2021
    Assignees: NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Ken Ishii, Kouji Kobiyama, Taiki Aoshi, Fumihiko Takeshita, Yuji Kasuya, Takako Niwa, Makoto Koizumi
  • Patent number: 10731159
    Abstract: The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: August 4, 2020
    Assignee: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Makoto Koizumi, Yoshiyuki Onishi, Takako Niwa, Masakazu Tamura, Yuji Kasuya
  • Publication number: 20200080086
    Abstract: The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.
    Type: Application
    Filed: November 22, 2019
    Publication date: March 12, 2020
    Inventors: Makoto KOIZUMI, Yoshiyuki ONISHI, Takako NIWA, Masakazu TAMURA, Yuji KASUYA
  • Patent number: 10533176
    Abstract: The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: January 14, 2020
    Assignee: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Makoto Koizumi, Yoshiyuki Onishi, Takako Niwa, Masakazu Tamura, Yuji Kasuya
  • Publication number: 20190112606
    Abstract: The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3?-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and ?-1,3-glucan.
    Type: Application
    Filed: December 20, 2018
    Publication date: April 18, 2019
    Applicants: NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Ken ISHII, Kouji KOBIYAMA, Taiki AOSHI, Fumihiko TAKESHITA, Yuji KASUYA, Takako NIWA, Makoto KOIZUMI
  • Patent number: 10202606
    Abstract: The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3?-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and ?-1,3-glucan.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: February 12, 2019
    Assignees: NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Ken Ishii, Kouji Kobiyama, Taiki Aoshi, Fumihiko Takeshita, Yuji Kasuya, Takako Niwa, Makoto Koizumi
  • Publication number: 20180051285
    Abstract: The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.
    Type: Application
    Filed: October 30, 2017
    Publication date: February 22, 2018
    Inventors: Makoto KOIZUMI, Yoshiyuki ONISHI, Takako NIWA, Masakazu TAMURA, Yuji KASUYA
  • Patent number: 9803199
    Abstract: The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: October 31, 2017
    Assignee: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Makoto Koizumi, Yoshiyuki Onishi, Takako Niwa, Masakazu Tamura, Yuji Kasuya
  • Publication number: 20160257951
    Abstract: The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.
    Type: Application
    Filed: July 7, 2014
    Publication date: September 8, 2016
    Inventors: Makoto KOIZUMI, Yoshiyuki ONISHI, Takako NIWA, Masakazu TAMURA, Yuji KASUYA
  • Publication number: 20160208260
    Abstract: The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3?-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and ?-1,3-glucan.
    Type: Application
    Filed: September 19, 2014
    Publication date: July 21, 2016
    Applicants: NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEAL TH AND NUTRITION, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Ken ISHII, Kouji KOBIYAMA, Taiki AOSHI, Fumihiko TAKESHITA, Yuji KASUYA, Takako NIWA, Makoto KOIZUMI
  • Patent number: 9155648
    Abstract: Disclosed herein is a stent delivery system which includes: a hollow shaft; first and second expandable balloons arranged around of the distal end of the shaft; and a stent which is arranged around the second balloon such that it expands as the second balloon expands; the first balloon having drug release means for releasing a drug at least to prevent the proliferation of endothelial cells, the stent being a bare metal stent to be indwelled at a target position as lesion of stenosis or occlusion in the lumen of a living body.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: October 13, 2015
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Takako Niwa
  • Publication number: 20140172114
    Abstract: Disclosed herein is a stent delivery system which includes: a hollow shaft; first and second expandable balloons arranged around of the distal end of the shaft; and a stent which is arranged around the second balloon such that it expands as the second balloon expands; the first balloon having drug release means for releasing a drug at least to prevent the proliferation of endothelial cells, the stent being a bare metal stent to be indwelled at a target position as lesion of stenosis or occlusion in the lumen of a living body.
    Type: Application
    Filed: February 24, 2014
    Publication date: June 19, 2014
    Applicant: Terumo Kabushiki Kaisha
    Inventor: Takako Niwa
  • Publication number: 20120245670
    Abstract: Disclosed herein is a stent delivery system which includes: a hollow shaft; first and second expandable balloons arranged around of the distal end of the shaft; and a stent which is arranged around the second balloon such that it expands as the second balloon expands; the first balloon having drug release means for releasing a drug at least to prevent the proliferation of endothelial cells, the stent being a bare metal stent to be indwelled at a target position as lesion of stenosis or occlusion in the lumen of a living body.
    Type: Application
    Filed: February 21, 2012
    Publication date: September 27, 2012
    Applicant: Terumo Kabushiki Kaisha
    Inventor: Takako NIWA
  • Publication number: 20110269942
    Abstract: The present invention relates to an immunoliposome preparation or a hydrophobic molecule-modified antibody having a therapeutic effect on cancer, autoimmune disease, or inflammatory disease. Specifically, the present invention relates to an immunoliposome or a hydrophobic molecule-modified antibody comprising, as a constituent, an antibody capable of inducing the apoptosis of cells expressing a death domain-containing receptor.
    Type: Application
    Filed: August 4, 2008
    Publication date: November 3, 2011
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Koji Morita, Takako Niwa, Yuji Kasuya, Kimihisa Ichikawa, Hiroko Yoshida
  • Publication number: 20100209490
    Abstract: The present invention relates to an immunoliposome preparation having a therapeutic effect on cancer, autoimmune disease, or inflammatory disease. Specifically, the present invention relates to an immunoliposome comprising, as a constituent, an antibody capable of inducing the apoptosis of cells expressing a death domain-containing receptor.
    Type: Application
    Filed: August 4, 2008
    Publication date: August 19, 2010
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Koji Morita, Takako Niwa, Kimihisa Ichikawa, Hiroko Yoshida