Abstract: An audio signal distribution method includes assigning in advance a reproduction role to each of a plurality of speakers, distributing an audio signal to the plurality of speakers, according to the reproduction role, and, in response to the number of speakers being decreased, causing a speaker paired with the released speaker on the reproduction role to further reproduce sound of the released speaker.

Abstract: A metal ratio inspection method for inspecting a metal ratio of a thermally sprayed composite material containing at least one metal and at least one ceramic, the method includes: an imaging step (step S11) of imaging the thermally sprayed composite material while irradiating the thermally sprayed composite material with imaging light; and an estimating step (step S12) of estimating a metal ratio of the thermally sprayed composite material based on a luminance distribution of the image of the thermally sprayed composite material obtained in the imaging step.

Abstract: A problem of the present invention is to obtain a preparation which shows markedly enhanced effectiveness and safety by exhibiting high accumulability at diseased areas and having the blood concentration maintained at a constant level without individual differences, and for which the control of the dosage depending on the blood kinetics (blood trough concentration) becomes unnecessary. The invention relates to a polymeric derivative of tacrolimus including a copolymer of a polyethylene glycol segment and a polymeric moiety, in which a carboxy group in a side chain of the copolymer is bonded to an alcoholic hydroxy group of tacrolimus.

Abstract: A monoclonal antibody, wherein the monoclonal antibody specifically binds to a single-chain type IV collagen polypeptide, and wherein the monoclonal antibody is obtained by a hybridoma line of Anti NK-Antigen monoclonal antibody #141 having Accession No: FERM BP-11300.

Abstract: The present invention provides a method for inhibiting cell growth, a nucleic acid molecule useful as an anticancer agent, and a method for screening novel anticancer agents. In the present invention, inhibitory effects on expression of NEK10 variant gene or inhibitory effects on activity of NEK10 variant protein are obtained in cells by transfecting cells with a nucleic acid molecule having an RNA interference effect on NEK10 variant gene. The present invention also provides a method for screening anticancer agents by using this inhibitory effect as an indicator.

Abstract: In accordance with the present invention, there are provided a gene encoding the promoter region of a protein p51 which is capable of inducing cell death, and a gene encoding the 5?-untranslated region of p51. These genes are useful in diagnosing and treating diseases including cancer caused by abnormal regulation of cell propagation. Furthermore, in accordance with the present invention, there are provided the antisense DNAs and the antisense RNAs of these genes, nucleic acid probes comprising parts or all of these genes, methods of detecting the above genes of the present invention or analogous genes using the nucleic acid probes, transformants in which the above gene of the present invention has been introduced, and methods of screening drugs using them. These genes are also useful in diagnosing and treating diseases including cancer, etc.

Abstract: A novel cystacycline derivative which has an excellent effect of promoting the differentiation of neurons and is useful as a remedy for central nervous system disorders, a remedy for peripheral nerve disorders, etc.