Abstract: The simulation device includes a simulation section and a calculation section. A simulation section is configured to simulate an operating status of a board work machine configured to perform predetermined board work on a board and produce a board product, and an operating status of an article moving device configured to supply an article needed for production of the board product to the board work machine based on a production plan of the board product. A calculation section is configured to calculate a production stop time of the board work machine caused by a wait time from when production of the board product by the board work machine is stopped to when the article is supplied by the article moving device based on a result of simulation by the simulation section.

Abstract: The object of the present invention is to provide a fundamental therapy to mitochondrial genetic diseases caused by mutation of the mitochondrial (mt)DNA, and a pharmaceutical composition used for the same. The object can be solved by a polyamide compound binding to a target double-stranded mtDNA comprising A/T pair consisting of first A of the following sense-stranded DNA and the corresponding T, A/T pair consisting of 8th A of the following sense-stranded DNA and the corresponding T, G/C pair consisting of 9th G of the following sense-stranded DNA and the corresponding C, G/C pair consisting of 14th G of the following sense-stranded DNA and the corresponding C, T/A pair consisting of 15th T of the following sense-stranded DNA and the corresponding A, or the like, in the double-stranded DNA consisting of the sense-stranded DNA having base sequence of 5?-ATGGCAGAGCCCGGTAATCGCATAA-3? (SEQ ID NO: 1) and the antisense-stranded DNA having base sequence of 5?-TTATGCGATTACCGGGCTCTGCCAT-3? (SEQ ID NO: 2).

Abstract: The object of the present invention is to provide a fundamental therapy to mitochondrial genetic diseases caused by mutation of the mitochondrial (mt)DNA, and a pharmaceutical composition used for the same. The object can be solved by a polyamide compound binding to a target double-stranded mtDNA comprising A/T pair consisting of first A of the following sense-stranded DNA and the corresponding T, A/T pair consisting of 8th A of the following sense-stranded DNA and the corresponding T, G/C pair consisting of 9th G of the following sense-stranded DNA and the corresponding C, G/C pair consisting of 14th G of the following sense-stranded DNA and the corresponding C, T/A pair consisting of 15th T of the following sense-stranded DNA and the corresponding A, or the like, in the double-stranded DNA consisting of the sense-stranded DNA having base sequence of 5?-ATGGCAGAGCCCGGTAATCGCATAA-3? (SEQ ID NO: 1) and the antisense-stranded DNA having base sequence of 5?-TTATGCGATTACCGGGCTCTGCCAT-3? (SEQ ID NO: 2).

Abstract: The object of the present invention is to provide a fundamental therapy to mitochondrial genetic diseases caused by mutation of the mitochondrial (mt)DNA, and a pharmaceutical composition used for the same. The object can be solved by a polyamide compound binding to a target double-stranded mtDNA comprising A/T pair consisting of first A of the following sense-stranded DNA and the corresponding T, A/T pair consisting of 8th A of the following sense-stranded DNA and the corresponding T, G/C pair consisting of 9th G of the following sense-stranded DNA and the corresponding C, G/C pair consisting of 14th G of the following sense-stranded DNA and the corresponding C, T/A pair consisting of 15th T of the following sense-stranded DNA and the corresponding A, or the like, in the double-stranded DNA consisting of the sense-stranded DNA having base sequence of 5?-ATGGCAGAGCCCGGTAATCGCATAA-3? (SEQ ID NO: 1) and the antisense-stranded DNA having base sequence of 5?-TTATGCGATTACCGGGCTCTGCCAT-3? (SEQ ID NO: 2).

Abstract: The object of the present invention is to provide a fundamental therapy to mitochondrial genetic diseases caused by mutation of the mitochondrial (mt)DNA, and a pharmaceutical composition used for the same. The object can be solved by a polyamide compound binding to a target double-stranded mtDNA comprising A/T pair consisting of first A of the following sense-stranded DNA and the corresponding T, A/T pair consisting of 8th A of the following sense-stranded DNA and the corresponding T, G/C pair consisting of 9th G of the following sense-stranded DNA and the corresponding C, G/C pair consisting of 14th G of the following sense-stranded DNA and the corresponding C, T/A pair consisting of 15th T of the following sense-stranded DNA and the corresponding A, or the like, in the double-stranded DNA consisting of the sense-stranded DNA having base sequence of 5?-ATGGCAGAGCCCGGTAATCGCATAA-3? (SEQ ID NO: 1) and the antisense-stranded DNA having base sequence of 5?-TTATGCGATTACCGGGCTCTGCCAT-3? (SEQ ID NO: 2).