Patents by Inventor Takanori Nagata

Takanori Nagata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190247414
    Abstract: The present invention provides a composition and a method for efficiently delivering a nucleic acid agent to the central nervous system and/or the retina and bringing about antisense effects. Provided is a composition for reducing the expression level of a target transcription product in the central nervous system and/or retina of a subject, the composition including a nucleic acid complex that includes a first nucleic acid strand and a second nucleic acid strand, wherein: the first nucleic acid strand comprises a base sequence capable of hybridizing with at least part of the target transcription product and has an antisense effect on the target transcription product; the second nucleic acid strand comprises a base sequence complementary to the first nucleic acid strand and is conjugated to tocopherol, cholesterol, or an analog thereof; and the first nucleic acid strand is annealed to the second nucleic acid strand.
    Type: Application
    Filed: September 25, 2017
    Publication date: August 15, 2019
    Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Takanori Yokota, Tetsuya Nagata
  • Patent number: 9009996
    Abstract: An excavating tooth includes a body and an abrasion-resistant layer. The abrasion-resistant layer has hardness higher than the body. The body includes a tip end face, a first face, a second face, a pair of first slope faces, and a pair of second slope faces. The abrasion-resistant layer includes a first abrasion-resistant layer section and a second abrasion-resistant layer section. The first abrasion-resistant layer section is formed on the tip end face. The second abrasion-resistant layer section is formed respectively on the pair of first slope faces and the pair of second slope faces. Thereby, it is possible to obtain an excavating tooth and a body for the excavating tooth capable of keeping a penetration force of a blade edge high in penetrating into an excavation subject.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: April 21, 2015
    Assignee: Komatsu Ltd.
    Inventors: Eiji Amada, Takanori Nagata, Kenichi Tanaka, Daijirou Itou
  • Patent number: 8997383
    Abstract: A bucket tooth assembly is mounted to an adapter provided to a distal end part of a bucket of construction equipment. The bucket assembly includes a bucket tooth and a latching member. The bucket tooth has a cavity for inserting the adapter and a through-hole that is provided to the side face and communicates through to the adapter when the bucket tooth has been mounted to the adapter. The through-hole has a center axis. The latching member is fitted inside the through-hole and having a rotational axis disposed along a direction of the center axis and a bottom part provided to an end on an adapter side in an axial direction. The latching member is rotated to switch between a first state in which the bottom part is held inside the through-hole and a second state in which the bottom part protrudes toward a concave portion on the adapter side.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: April 7, 2015
    Assignee: Komatsu Ltd.
    Inventors: Daijirou Itou, Takanori Nagata, Eiji Amada, Tsuyoshi Yoshida
  • Patent number: 8851826
    Abstract: A bottom surface part of a bucket includes first and second curved surface parts. The second curved surface part is positioned closer to a back surface part than the first curved surface part. A second curvature radius of the second curved surface part is shorter than a first curvature radius of the first curved surface part. The center of the first curvature radius is positioned to the outside of a main bucket body when viewed from the side. In a horizontal state, the first curved surface part is arranged along or above a reference curved surface when viewed from the side. A connecting part between the first curved surface part and the second curved surface part is positioned more towards a lip part than the portion of the bottom surface part that is positioned lowest in the bottom surface part in the horizontal state when viewed from the side.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: October 7, 2014
    Assignee: Komatsu Ltd.
    Inventors: Takanori Nagata, Kenichi Higuchi, Masakuni Ueda, Kouzou Ishida, Daijirou Itou
  • Patent number: 8832975
    Abstract: A bucket tooth for a construction vehicle includes a through-hole formed in a side wall part and passing through to a cavity. The through-hole has on a cavity side a rotating body hole having a shape of a truncated and rotated cone that remains after removing a large diameter side portion obtained by cutting diagonally to a rotational axis of the truncated and rotated cone with a large diameter side of the truncated and rotated cone being disposed on the cavity side, and with the rotational axis of the truncated and rotated cone being inclined outwardly toward the distal end portion of the bucket tooth from the cavity along a width direction of the bucket tooth.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: September 16, 2014
    Assignee: Komatsu Ltd.
    Inventors: Daijirou Itou, Takanori Nagata, Eiji Amada, Tsuyoshi Yoshida
  • Publication number: 20140215867
    Abstract: An excavating tooth includes a body and an abrasion-resistant layer. The abrasion-resistant layer has hardness higher than the body. The body includes a tip end face, a first face, a second face, a pair of first slope faces, and a pair of second slope faces. The abrasion-resistant layer includes a first abrasion-resistant layer section and a second abrasion-resistant layer section. The first abrasion-resistant layer section is formed on the tip end face. The second abrasion-resistant layer section is formed respectively on the pair of first slope faces and the pair of second slope faces. Thereby, it is possible to obtain an excavating tooth and a body for the excavating tooth capable of keeping a penetration force of a blade edge high in penetrating into an excavation subject.
    Type: Application
    Filed: January 29, 2013
    Publication date: August 7, 2014
    Applicant: KOMATSU LTD.
    Inventors: Eiji Amada, Takanori Nagata, Kenichi Tanaka, Daijirou Itou
  • Patent number: 8679207
    Abstract: Disclosed is a wear-resistant particle which can be substantially uniformly dispersed in a molten pool. Specifically disclosed is a wear-resistant particle (13) which is dispersed in a matrix metal for improving wear resistance thereof. The wear-resistant particle is characterized by being composed of a material containing a first hard material and a second hard material while having a particle diameter of 0.2-9 mm. The wear-resistant particle is further characterized in that the material consists of 60-96% by volume of a carbide and the balance of a metal.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: March 25, 2014
    Assignees: Komatsu Ltd., Japan New Metals Co., Ltd.
    Inventors: Masaharu Amano, Takanori Nagata, Mitsushi Inoshita, Kenji Iwamoto
  • Patent number: 8495826
    Abstract: A work implement includes a ground engaging tool with a first through-hole, an adapter with a second through-hole, a retaining pin, a metal bushing and a metal retainer. The retaining pin is inserted into the first and second through-holes disposed in a state in which the ground engaging tool is in contact with the adapter. The retaining pin is inserted in an inside of an cylindrical member of the bushing, which is disposed at an end portion of the retaining pin inside the first through-hole. The metal retainer prevents the bushing from coming loose from the retaining pin by sandwiching the bushing between the metal retainer and the adapter at the end of the retaining pin. The bushing is disposed in a state that allows movement in an axial direction of the retaining pin between the adapter and the retainer on an outer peripheral face of the retaining pin.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: July 30, 2013
    Assignee: Komatsu Ltd.
    Inventors: Daijirou Itou, Kouzou Ishida, Takanori Nagata, Keita Mutou
  • Publication number: 20130152432
    Abstract: A bucket tooth for a construction vehicle includes a through-hole formed in a side wall part and passing through to a cavity. The through-hole has on a cavity side a rotating body hole having a shape of a truncated and rotated cone that remains after removing a large diameter side portion obtained by cutting diagonally to a rotational axis of the truncated and rotated cone with a large diameter side of the truncated and rotated cone being disposed on the cavity side, and with the rotational axis of the truncated and rotated cone being inclined outwardly toward the distal end portion of the bucket tooth from the cavity along a width direction of the bucket tooth.
    Type: Application
    Filed: May 7, 2012
    Publication date: June 20, 2013
    Applicant: Komatsu Ltd.
    Inventors: Daijirou Itou, Takanori Nagata, Eiji Amada, Tsuyoshi Yoshida
  • Publication number: 20130152433
    Abstract: A bucket tooth assembly is mounted to an adapter provided to a distal end part of a bucket of construction equipment. The bucket assembly includes a bucket tooth and a latching member. The bucket tooth has a cavity for inserting the adapter and a through-hole that is provided to the side face and communicates through to the adapter when the bucket tooth has been mounted to the adapter. The through-hole has a center axis. The latching member is fitted inside the through-hole and having a rotational axis disposed along a direction of the center axis and a bottom part provided to an end on an adapter side in an axial direction. The latching member is rotated to switch between a first state in which the bottom part is held inside the through-hole and a second state in which the bottom part protrudes toward a concave portion on the adapter side.
    Type: Application
    Filed: April 26, 2012
    Publication date: June 20, 2013
    Inventors: Daijirou Itou, Takanori Nagata, Eiji Amada, Tsuyoshi Yoshida
  • Publication number: 20120301258
    Abstract: A bottom surface part of a bucket includes first and second curved surface parts. The second curved surface part is positioned closer to a back surface part than the first curved surface part. A second curvature radius of the second curved surface part is shorter than a first curvature radius of the first curved surface part. The center of the first curvature radius is positioned to the outside of a main bucket body when viewed from the side. In a horizontal state, the first curved surface part is arranged along or above a reference curved surface when viewed from the side. A connecting part between the first curved surface part and the second curved surface part is positioned more towards a lip part than the portion of the bottom surface part that is positioned lowest in the bottom surface part in the horizontal state when viewed from the side.
    Type: Application
    Filed: October 19, 2010
    Publication date: November 29, 2012
    Applicant: KOMATSU LTD.
    Inventors: Takanori Nagata, Kenichi Higuchi, Masakuni Ueda, Kouzou Ishida, Daijirou Itou
  • Publication number: 20120222336
    Abstract: A work implement includes a ground engaging tool with a first through-hole, an adapter with a second through-hole, a retaining pin, a metal bushing and a metal retainer. The retaining pin is inserted into the first and second through-holes disposed in a state in which the ground engaging tool is in contact with the adapter. The retaining pin is inserted in an inside of an cylindrical member of the bushing, which is disposed at an end portion of the retaining pin inside the first through-hole. The metal retainer prevents the bushing from coming loose from the retaining pin by sandwiching the bushing between the metal retainer and the adapter at the end of the retaining pin. The bushing is disposed in a state that allows movement in an axial direction of the retaining pin between the adapter and the retainer on an outer peripheral face of the retaining pin.
    Type: Application
    Filed: March 30, 2011
    Publication date: September 6, 2012
    Applicant: KOMATSU LTD.
    Inventors: Daijirou Itou, Kouzou Ishida, Takanori Nagata, Keita Mutou
  • Publication number: 20090019783
    Abstract: Disclosed is a wear-resistant particle which can be substantially uniformly dispersed in a molten pool. Specifically disclosed is a wear-resistant particle (13) which is dispersed in a matrix metal for improving wear resistance thereof. The wear-resistant particle is characterized by being composed of a material containing a first hard material and a second hard material while having a particle diameter of 0.2-9 mm. The wear-resistant particle is further characterized in that the material consists of 60-96% by volume of a carbide and the balance of a metal.
    Type: Application
    Filed: March 30, 2007
    Publication date: January 22, 2009
    Inventors: Masaharu Amano, Takanori Nagata, Mitsushi Inoshita, Kenji Iwamoto
  • Publication number: 20060228227
    Abstract: There is provided a control valve for a variable capacity compressor, which is applicable to a compressor of large capacity.
    Type: Application
    Filed: April 11, 2006
    Publication date: October 12, 2006
    Applicant: Fujikoki Corporation
    Inventors: Daisuke Mori, Takanori Nagata
  • Patent number: 6571493
    Abstract: A cutting edge which has improved resistance to scratching wear, such resistance being required for cutting edges for snow removal, which has good performance to increase e.g., compressed snow rate, and which can be manufactured at comparatively low cost. The cutting edge comprises a hard member provided at the leading edge of an edge body, the hard member comprising (i) a hard material containing hard grains which are dispersed with high filling density and integrally combined by a metal having a lower melting point than the hard grains and (ii) a protective member which covers at least the front face of the hard material as viewed in the travel direction of the blade and which has impact resistance.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: June 3, 2003
    Assignee: Komatsu Ltd.
    Inventors: Masaharu Amano, Takanori Nagata, Kazuhide Okawa
  • Patent number: 6454195
    Abstract: The invention relates to an industrial waste crushing bit capable of sufficiently exerting wear resistance from the initial stage of service and improving the service life at low cost. A super-hard member to be inserted in an opening formed in the tip of a bit body is formed into a plate shape and is secured to the bit body in such a manner that the plate faces of the plated-shaped super-hard member are placed in a direction virtually orthogonal to the rotational direction of the bit, with its side being exposed.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: September 24, 2002
    Assignee: Komatsu Ltd.
    Inventors: Masaharu Amano, Takanori Nagata, Kazuhide Okawa, Toshisuke Isoya
  • Publication number: 20010005949
    Abstract: A cutting edge which has improved resistance to scratching wear, such resistance being required for cutting edges for snow removal, which has good performance to increase e.g., compressed snow rate, and which can be manufactured at comparatively low cost. The cutting edge comprises a hard member provided at the leading edge of an edge body, the hard member comprising (i) a hard material containing hard grains which are dispersed with high filling density and integrally combined by a metal having a lower melting point than the hard grains and (ii) a protective member which covers at least the front face of the hard material as viewed in the travel direction of the blade and which has impact resistance.
    Type: Application
    Filed: December 22, 2000
    Publication date: July 5, 2001
    Applicant: KOMATSU LTD.,
    Inventors: Masaharu Amano, Takanori Nagata, Kazuhide Okawa