Abstract: The present invention aims to provide a novel drug delivery system (DDS) technique capable of selectively delivering a drug (compound containing oligonucleotides for producing at least partially functional dystrophin protein) to muscle tissues such as cardiac muscle, skeletal muscle and the like and efficiently introducing the drug into the muscle cells. The present invention relates to a conjugate or a salt thereof including the following: (1) a peptide that binds to a transferrin receptor, and contains the amino acid sequence shown in SEQ ID NO: 1 (Ala-Val-Phe-Val-Trp-Asn-Tyr-Tyr-Ile-Ile-Ser-Cys); or an amino acid sequence resulting from substitution, deletion, addition, and/or insertion of not less than one and not more than 10 amino acid residues in the amino acid sequence shown in SEQ ID NO: 1, and (2) a compound comprising an oligonucleotide for producing an at least partially functional dystrophin protein.

Abstract: A liquid ejecting apparatus includes: a container that contains a liquid having conductivity; an electrode bar that is disposed inside the container and that includes a first terminal, a second terminal, and a first insulating section that electrically insulates the first terminal from the second terminal; a detection section that detects a remaining amount of liquid contained in the container in accordance with an electrical signal from at least one of the first terminal and the second terminal; and a liquid ejection head that discharges the liquid supplied from the container. The remaining amount of liquid detected by the detection section when the first terminal is electrically coupled to the second terminal via the liquid in the container is larger than the remaining amount of liquid detected by the detection section when the first terminal is not electrically coupled to the second terminal via the liquid in the container.

Abstract: A liquid discharging apparatus includes an accommodating container accommodating conductive liquid, a rod-shaped first electrode accommodated in the accommodating container, a rod-shaped second electrode accommodated in the accommodating container, a detection portion that is electrically coupled to the first electrode and the second electrode and that detects a remaining amount of the liquid accommodated in the accommodating container in response to an electric signal from at least one of the first electrode and the second electrode, and a liquid discharging head discharging the liquid that is supplied from the accommodating container, in which the first electrode includes a first part having an outer periphery with a first length, and a second part having an outer periphery with a second length that is shorter than the first length.

Abstract: A liquid discharging apparatus includes an accommodating container accommodating conductive liquid, a first electrode accommodated in the accommodating container, a second electrode accommodated in the accommodating container, a detection portion that is electrically coupled to the first electrode and the second electrode and that detects a remaining amount of the liquid accommodated in the accommodating container in response to an electric signal from at least one of the first electrode and the second electrode, and a liquid discharging head discharging the liquid that is supplied from the accommodating container, in which the first electrode includes a first part where a distance between the first part and the second electrode is a first distance, and a second part where a distance between the second part and the second electrode is a second distance that is longer than the first distance.

Abstract: A liquid accommodating device includes an accommodating container accommodating conductive liquid, a first electrode accommodated in the accommodating container, a second electrode accommodated in the accommodating container, and a detection portion that is electrically coupled to the first electrode and the second electrode and that detects a remaining amount of the liquid accommodated in the accommodating container in response to an electric signal from at least one of the first electrode and the second electrode, in which the first electrode includes a first part where a first conduction portion formed with a conductive member is exposed, a second part where the first conduction portion is exposed, and a first insulation part that is provided between the first part and the second part and in which the first conduction portion is covered with an insulation member.

Abstract: A disc brake caliper of a human-powered vehicle comprises a caliper body and a first piston. The caliper body includes a first hole. The first piston is movably provided in the first hole. The first piston has a first outer diameter. The first outer diameter is larger than or equal to 19 mm.

Abstract: A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.

Abstract: In an axial flow fan, a plurality of blades are rotated about a rotation axis of the plurality of blades to generate an air current. Each of the plurality of blades includes a leading edge portion on a forward side in a rotation direction, and a trailing edge portion on a rearward side in the rotation direction. At the trailing edge portion of the blade, a first recessed portion is formed such that the first recessed portion is recessed toward the leading edge portion. At the leading edge portion of the blade, the second recessed portion is recessed toward the trailing edge portion. Ranges of the first recessed portion and the second recessed portion in a radial direction overlap with each other or completely coincide with each other.

Abstract: A radiographic imaging apparatus includes an image processor configured to perform image processing on a radiation image generated by an image generator, and a display configured to display a processed image that has been subjected to the image processing in the image processor. The image processor is configured to perform control to create the processed image showing an expanded portion in which a balloon introduced into a subject is expanded.

Abstract: An image synthesis unit of an X-ray imaging apparatus is configured to correct a synthesis target image or a transparent image based on movement information of a feature point and movement information of a pixel and generate a synthesized image by synthesizing a corrected synthesis target image and a transparent image or synthesizing a synthesis target image and a corrected transparent image.

Abstract: This image processing apparatus is provided with an image acquisition unit for generating a concentration change image and a control unit for performing control for displaying a blood vessel image and a concentration change image, and the control unit is configured to perform control for accepting a selection of a target region on the blood vessel image displayed on the display unit and for displaying the concentration change image corresponding to the selected target region.

Abstract: An air filter includes a frame portion including an outer frame and an inner frame, the outer frame being a frame body forming an outer contour and formed with an opening, the inner frame being provided within the outer frame and configured to partition the opening of the outer frame into a grid shape, and a filter portion provided on the frame portion to cover sections surrounded by the outer frame and the inner frame, the filter portion being configured to adsorb dust, wherein one side of the frame portion is totally flat.

Abstract: Provided is a rear vehicle-body structure of a vehicle, capable of reducing vibrations transmitted from a rear wheel to a floor panel, while ensuring required performance for rear side frames and a cross member. The rear vehicle-body structure comprises a symmetric pair of frame members extending in a vehicle longitudinal direction along respective lateral sides of a rear of a vehicle body of the vehicle, and a rear-side rear cross member bridging the symmetric pair of frame members in a vehicle width direction, wherein an attachment portion between each of the frame members and the rear-side rear cross member provided with rigidity difference generation part to generate a rigidity difference between the frame member and the rear-side rear cross member.

Abstract: A hydraulic device comprises a base member, a piston, a seal ring, and an intermediate member. The base member includes a cylinder bore and an annular groove. The annular groove includes a first inner surface and a second inner surface. The piston is movable relative to the base member from a rest position toward an actuated position in a second direction opposite to a first direction. The piston is movable relative to the base member from the actuated position toward the rest position in the first direction. The seal ring includes a first axial surface facing in the first direction and a second axial surface facing in the second direction. The seal ring is provided in the annular groove so as to define a clearance between the first axial surface and the first inner surface. The intermediate member is provided in the clearance.

Abstract: A hydraulic device comprises a base member, a piston, a seal ring, and an intermediate member. The base member includes a cylinder bore and an annular groove. The annular groove includes a first inner surface and a second inner surface. The piston is movable relative to the base member from a rest position toward an actuated position in a second direction opposite to a first direction. The piston is movable relative to the base member from the actuated position toward the rest position in the first direction. The seal ring includes a first axial surface facing in the first direction and a second axial surface facing in the second direction. The seal ring is provided in the annular groove so as to define a clearance between the first axial surface and the first inner surface. The intermediate member is provided in the clearance.

Abstract: Provided is a radiographic imaging apparatus capable of easily and properly performing a selection operation or a playback operation of the moving image and a frame feeding operation of the moving image. An operation unit is provided with a tiltable lever and a rotation input portion provided at an upper end of the lever. The image processing unit performs a selection operation or a playback operation of the moving image to be displayed on the display unit according to a tilting operation of the lever, and performs a frame feeding operation of the moving image to be displayed on the display unit according to a rotating operation of the rotation input portion.

Abstract: An X-ray imaging apparatus includes a moving unit for changing an irradiation position which is a position of a subject to be irradiated with X-rays by moving at least one of an imaging unit for emitting X-rays to a subject and a top board, and a control unit for performing control for displaying on a first display unit a two-dimensional virtual plane image which is a two-dimensional image in which an image indicating the skin dose for each of a plurality of irradiation positions and a scale image indicating at least one of the distance and the angle with respect to a reference position are superimposed on a virtual plane.

Abstract: An image processor (13) of an X-ray imaging apparatus (100) is configured to be switchable to a full period image composition mode in which a composite image (M) is generated by superimposing images in an entirety of an image generation period and a partial period image composition mode in which the composite image is generated by superimposing the images in a part of the image generation period.

Abstract: This X-ray imaging apparatus includes a control unit for performing control to select one blood vessel image in which a blood vessel is clearly reflected from a plurality of blood vessel images stored in the storage unit when capturing a fluoroscopic image and performing control to display a superimposed image in which the selected blood vessel image and the fluoroscopic image are superimposed on the display unit.

Abstract: Provided is a radiographic imaging apparatus capable of easily and properly performing a selection operation or a playback operation of the moving image and a frame feeding operation of the moving image. An operation unit is provided with a tiltable lever and a rotation input portion provided at an upper end of the lever. The image processing unit performs a selection operation or a playback operation of the moving image to be displayed on the display unit according to a tilting operation of the lever, and performs a frame feeding operation of the moving image to be displayed on the display unit according to a rotating operation of the rotation input portion.