Abstract: An adhesion preventive material including a cross-linking polysaccharide derivative containing at least one active ester group introduced in a polysaccharide side chain, which is capable of reacting with an active hydrogen-containing group, and being capable of forming a crosslinked material due to covalent binding among the active ester group and an active hydrogen-containing group upon contact with water under an alkaline condition, is disclosed. The adhesion preventive material is able to reduce preparation works to be carried out while previously estimating the time of application and dose not require a special device.

Abstract: A crosslinkable polysaccharide derivative which has in the side chain of polysaccharide at least one active ester group reactive with an active hydrogen-containing group and which forms a crosslinked product through covalent bond between the active ester group and the active hydrogen-containing group upon contact with alkaline water. A composition and a medical treatment material containing the crosslinkable polysaccharide derivative. The crosslinkable polysaccharide derivative produces a high bond strength that meets clinical requirements. It avoids the risk of infection because it is based on a material which is not derived from living organisms. It in itself and its decomposition products have a low level of toxicity because it is formed from a synthetic material. It is biodegradable and bioabsorbable. It can be prepared readily and simply without requiring special apparatus at the time of use.

Abstract: To provide an artificial cardiopulmonary circuit system having high heat resistance and excellent blood compatibility. The artificial cardiopulmonary circuit system includes a hollow fiber membrane oxygenator including a plurality of porous hollow fiber membranes for gas exchange having a blood contact part that contacts blood on one side thereof and a gas contact part that contacts a gas on the other side thereof, and a housing that contains the hollow fiber membranes therein. At least a portion of the blood contact part of the hollow fiber membrane oxygenator is coated with a polymer comprising a repeating unit represented by the following general formula (1) as a main structural component and having a viscosity at 65° C. of 5,000 poise (500 Pa·s) [Chemical Formula 4] (Wherein R1 is hydrogen or a methyl group, R2 is an alkylene group having 1 to 4 carbon atoms, and R3 is an alkyl group having 1 to 4 carbon atoms).

Abstract: To provide a biocompatible material with a high level of safety at a low cost. The biocompatible material has a polymer synthesized from monomers by an anionic polymerization, wherein the polymer has a ratio (Mw/Mn) of a weight-average molecular weight (Mw) to a number-average molecular weight (Mn) in a range of 1.0 to 1.5, in which the weight-average molecular weight is 40,000 or more, and each of the monomers is represented by a following general formula (1): where R1 is a hydrogen atom or a methyl group; R2 is a C1-C4 alkylene group; and R3 is a C1-C4 alkyl group.

Abstract: To provide an artificial cardiopulmonary circuit system having high heat resistance and excellent blood compatibility. The artificial cardiopulmonary circuit system includes a hollow fiber membrane oxygenator including a plurality of porous hollow fiber membranes for gas exchange having a blood contact part that contacts blood on one side thereof and a gas contact part that contacts a gas on the other side thereof, and a housing that contains the hollow fiber membranes therein. At least a portion of the blood contact part of the hollow fiber membrane oxygenator is coated with a polymer comprising a repeating unit represented by the following general formula (1) as a main structural component and having a viscosity at 65° C.

Abstract: A hollow fiber membrane oxygenator of external blood circulation type has a housing and a lot of porous hollow fiber membranes for gas transfer housed in the housing. In the oxygenator, blood flows along the outer side of the hollow fiber membranes, whereas oxygen-containing gas flows along the inner side thereof. An outer surface or outer layer of the hollow fiber membrane as a blood-contacting portion is coated with synthetic polymer mainly formed of alkoxyalkyl(meta)acrylate containing a C(1-4)alkoxy group and a C(1-4)alkyl group. An intermediate layer and inner layer of the hollow fiber membranes contain substantially no synthetic polymer.

Abstract: To provide a biocompatible material with a high level of safety at a low cost. The biocompatible material has a polymer synthesized from monomers by an anionic polymerization, wherein the polymer has a ratio (Mw/Mn) of a weight-average molecular weight (Mw) to a number-average molecular weight (Mn) in a range of 1.0 to 1.