Patents by Inventor Takao Kishiye

Takao Kishiye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multidrug resistance inhibitors
    Patent number: 6011069
    Abstract: There is disclosed a multidrug resistance inhibitor for overcoming a multidrug resistance of cancer, or an agent for enhancing the activity of anti-cancer agents, which comprises as an active ingredient a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein n is an integer of 5 to 12,R.sub.1 and R.sub.2 are each independently benzyl, of which a phenyl ring may be substituted by 1 to 5 substituents selected from hydroxy, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy and halogen, and/or by methylenedioxy, with the proviso that R.sub.1 and R.sub.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: January 4, 2000
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Kohei Inomata, Toshihiro Takahashi, Hitoshi Inoue, Makoto Yanai, Hiroyuki Yamazaki, Masashi Suzuki, Tsutomu Takasawa, Kouji Kawamura, Norio Oshida, Hiroyuki Ikemoto, Takao Kishiye
  • Pharmaceutical composition for the treatment of leukemia containing 9-cis-retinoic acid-.alpha.-tocopherol ester
    Patent number: 5929057
    Abstract: 9-Cis-retinoic acid-.alpha.-tocopherol esters, pharmaceutical compositions containing the same and use of the same as a medicine for the treatment of leukemia, in particular, the remission of leukemia are provided and a combined use of a 9-cis-retinoic acid-.alpha.-tocopherol ester and either 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid exhibits a synergistic effect in the treatment of leukemia without any side effects caused by 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid.
    Type: Grant
    Filed: June 5, 1998
    Date of Patent: July 27, 1999
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Makoto Makishima, Yasuhiro Kanatani, Yoshio Honma, Kohei Inomata, Takao Kishiye
  • Pharmaceutical composition for the treatment of leukemia containing 9-cis-retinoic acid-.alpha.-tocopherol ester
    Patent number: 5827878
    Abstract: 9-Cis-retinoic acid-.alpha.-tocopherol esters, pharmaceutical compositions containing the same and use of the same as a medicine for the treatment of leukemia, in particular, the remission of leukemia are provided and a combined use of a 9-cis-retinoic acid-.alpha.-tocopherol ester and either 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid exhibits a synergistic effect in the treatment of leukemia without any side effects caused by 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: October 27, 1998
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Makoto Makishima, Yasuhiro Kanatani, Yoshio Honma, Kohei Inomata, Takao Kishiye
  • Isoprene derivatives
    Patent number: 5756475
    Abstract: Isoprene derivatives of formula (I) ##STR1## wherein m is an integer of 0 to 3,n is an integer of 5 to 12,A is cyclo(C.sub.3 -C.sub.6)alkylene, phenylene, fluorenylene, pyrrolidinylene, piperazinylene, 9-aza-3-oxabicyclo?3.3.1!-nonylene,R.sub.1 and R.sub.2 are each independently benzyl, of which a phenyl ring may be substituted by 1 to 5 substituents selected from the group consisting of hydroxy, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy and halogen,X is a single bond or a divalent radical of --(CH.sub.2).sub.p NH--,p is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof. Those compounds are useful as multidrug resistance inhibitors for overcoming multidrug resistance of cancer and agents for enhancing an activity of anti-cancer agents.
    Type: Grant
    Filed: January 30, 1997
    Date of Patent: May 26, 1998
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Kohei Inomata, Toshihiro Takahashi, Hitoshi Inoue, Makoto Yanai, Hiroyuki Yamazaki, Masashi Suzuki, Tsutomu Takasawa, Kouji Kawamura, Norio Oshida, Hiroyuki Ikemoto, Takao Kishiye
  • Pharmaceutical compositions for the treatment of skin diseases
    Patent number: 4829082
    Abstract: This invention relates to pharmaceutical compositions for the treatment of skin diseases which comprises as an active ingredient vitamin A esters of .alpha.-tocopherol.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: May 9, 1989
    Assignee: Nisshin Chemicals Co., Ltd.
    Inventors: Hiroshi Shinkai, Takao Kishiye