Abstract: The present invention relates to a compound having inhibitory activity against KRAS G12D mutation or a salt thereof, and relates to a pharmaceutical composition comprising the compound as an active ingredient.

Abstract: The present invention provides an antitumor agent for treating a malignant tumor patient expressing EGFR having at least one mutation selected from the group consisting of L718X mutation in exon 18 and L792X mutation in exon 20, wherein X represents an arbitrary amino-acid residue, the antitumor agent comprising (S)-N-(4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl)acrylamide (Compound (A)) or a salt thereof.

Abstract: A waterproof sheet which is for application to a site to be waterproofed in order to prevent rainwater infiltration thereinto and retard deteriorations which proceed with time, the waterproof sheet comprising: a base layer that comprises a silicone rubber composition reinforced with reinforcing fibers and that has physical properties including high strength; and a pressure-sensitive silicone adhesive layer that has been formed on one surface of the base layer and that has a low hardness and is highly tacky. The waterproof sheet provided by the present invention less breaks than conventional waterproof sheets because of the reinforcement layer, and can conform to cracks or dislocations occurring in the surfaces to which the waterproof sheet has been applied, due to the pressure-sensitive adhesive layer formed on one surface.

Abstract: Provided are crystals of 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide which are stable and show excellent oral absorbability. The crystals are Form II crystals of 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide showing an X-ray powder diffraction spectrum having at least three characteristic diffraction peaks at angles (2?±0.2°) selected from the group consisting of 7.7°, 8.0°, 11.1°, 12.5°, 12.9°, 15.2°, 15.8°, 17.2°, 19.0°, 22.5°, 26.1°, and 27.4°.

Abstract: Provided are crystals of 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide which are stable and show excellent oral absorbability. The crystals are Form II crystals of 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide showing an X-ray powder diffraction spectrum having at least three characteristic diffraction peaks at angles (2?±0.2°) selected from the group consisting of 7.7°, 8.0°, 11.1°, 12.5°, 12.9°, 15.2°, 15.8°, 17.2°, 19.0°, 22.5°, 26.1°, and 27.4°.

Abstract: Provided are crystals of 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide which are stable and show excellent oral absorbability. The crystals are Form II crystals of 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide showing an X-ray powder diffraction spectrum having at least three characteristic diffraction peaks at angles (2?±0.2°) selected from the group consisting of 7.7°, 8.0°, 11.1°, 12.5°, 12.9°, 15.2°, 15.8°, 17.2°, 19.0°, 22.5°, 26.1°, and 27.4°.

Abstract: This waterproof sheet made of a silicone rubber is characterized by being provided with: a base material layer obtained by curing a silicone rubber composition; and a pressure-sensitive adhesive layer comprising a cured product of a silicone gel composition laminated on one surface of the base material layer, wherein, on the other surface of the base material layer, a coating layer containing a silicone resin represented by average composition formula (1): [RSiO3/2]m[R2SiO]n (in the formula, each R represents an identical or a different monovalent hydrocarbon group that is unsubstituted or substituted and that contains 1-20 carbon atoms, m is 0.45-1.0, n is 0-0.55, and m+n?1.0 is satisfied) is included.

Abstract: A waterproof sheet which is for application to a site to be waterproofed in order to prevent rainwater infiltration thereinto and retard deteriorations which proceed with time, the waterproof sheet comprising: a base layer that comprises a silicone rubber composition reinforced with reinforcing fibers and that has physical properties including high strength; and a pressure-sensitive silicone adhesive layer that has been formed on one surface of the base layer and that has a low hardness and is highly tacky. The waterproof sheet provided by the present invention less breaks than conventional waterproof sheets because of the reinforcement layer, and can conform to cracks or dislocations occurring in the surfaces to which the waterproof sheet has been applied, due to the pressure-sensitive adhesive layer formed on one surface.

Abstract: Provided are crystals of 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide which are stable and show excellent oral absorbability. The crystals are Form II crystals of 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide showing an X-ray powder diffraction spectrum having at least three characteristic diffraction peaks at angles (2?±0.2°) selected from the group consisting of 7.7°, 8.0°, 11.1°, 12.5°, 12.9°, 15.2°, 15.8°, 17.2°, 19.0°, 22.5°, 26.1°, and 27.4°.

Abstract: An object of the present invention is to provide a method for reproducibly producing a pyrrolopyrimidine ring-containing tricyclic compound in high yield with reduced formation of by-products, and to provide a novel tricyclic compound capable of being obtained by this production method. The present invention provides a method for producing a compound represented by Formula (1) or a salt thereof, the method comprising the steps of: (I) causing an organic borane reagent to act on a compound represented by Formula (2) or a salt thereof, and (II) performing an intramolecular cyclization reaction of the reaction product of step (I) above using a zerovalent palladium catalyst in the presence of an alkali metal hydroxide.

Abstract: A method for producing a pyrrolopyrimidine ring-containing tricyclic compound represented by Formula (1) or a salt thereof. The method comprising the steps of: (I) reacting an organoborane reagent with a compound represented by Formula (2) or a salt thereof, and (II) performing an intramolecular cyclization reaction of the reaction product of step (I) in the presence of a zerovalent palladium catalyst and an alkali metal hydroxide.

Abstract: A waterproof sheet which comprises a base layer constituted of a silicone rubber and a pressure-sensitive adhesive layer superposed thereon and which is for use in preventing the infiltration of rainwater, etc., characterized in that the pressure-sensitive adhesive layer is constituted of a cured object of an addition reaction type curable silicone composition in which the theoretical amount of crosslinks is 0.005-0.01 mol/g and the ratio of the amount of SiH groups to the amount of alkenyl groups, SiH/alkenyl, is 0.5-1.1 by mole and which, when cured, has a hardness as measured with a CSR-2 type hardness meter of 3-20. This waterproof sheet can be used over a long period without decreasing in physical property, and has waterproofing properties over a long period. In particular, by delimiting the hardness and adhesive force of the pressure-sensitive adhesive layer, the waterproof sheet can be made to withstand long-term use.

Abstract: Provided is a waterproof sheet such that an adhesive layer is formed on a substrate rubber layer and characterized by the substrate rubber layer comprising a silicone rubber having a JIS-A hardness of 15-90, a tensile strength of at least 3 MPa, an elongation of 100-800%, and a crescent tear strength of at least 3 kN/m. The waterproof sheet can be used without a long-term decrease in material properties, and is waterproof in the long-term. In particular, the present invention can be a waterproof sheet able to withstand long-term use by means of stipulating the material properties of the substrate rubber. By means of a method for applying waterproofing to an outdoor tank, it is possible to reliably waterproof the bottom side of the outdoor tank by means of a simple application method.

Abstract: A fluorosilicone rubber composition comprising (A) an alkenyl-rich fluorosilicone gum, (B) an alkenyl-poor fluorosilicone gum, (C) reinforcing silica, and (D) a curing catalyst cures into a product which experiences little change of physical strength even after immersion in alcohol-containing fuel oil.

Abstract: When a bridge pier is reinforced or repaired by wrapping a reinforcement around the pier, a waterproof sheet having a sufficient flexibility to attach to and cover the interface between the pier and the reinforcement in a liquid-tight manner is useful. The waterproof sheet is attached to the interface between the pier and the reinforcement to prevent water from penetrating into the interface for thereby preventing the reinforcement from deterioration.

Abstract: An object to be achieved by the present invention is to provide a novel compound having EGFR inhibitory effects and cell growth inhibitory effects, as well as a medication useful for the prevention and/or treatment of cancer based on the EGFR inhibitory effects. The present invention provides a compound represented by Formula (I) below, or a salt thereof.

Abstract: An object to be achieved by the present invention is to provide a novel compound having EGFR inhibitory effects and cell growth inhibitory effects, as well as a medication useful for the prevention and/or treatment of cancer based on the EGFR inhibitory effects. The present invention provides a compound represented by Formula (I) below, or a salt thereof.

Abstract: An object to be achieved by the present invention is to provide a novel compound having EGFR inhibitory effects and cell growth inhibitory effects, as well as a medication useful for the prevention and/or treatment of cancer based on the EGFR inhibitory effects. The present invention provides a compound represented by Formula (I) below, or a salt thereof.

Abstract: The present invention relates to a waterproofing method for an outdoor tank, the waterproofing method being characterized in that the boundary portion between the bottom of the outdoor tank installed on a foundation and the foundation is covered in a liquid tight manner by a waterproof sheet adhered so as to extend from the outdoor tank to the foundation. The present invention can provide a waterproofing method which is effective to prevent the entry of rain water into the boundary portions between the bottoms of outdoor tanks and the foundations, most of the outdoor tanks being large tanks mainly installed in oil refineries or the like. This waterproofing method for an outdoor tank can more reliably waterproof the bottom side of the outdoor tank using the simple method.

Abstract: An object to be achieved by the present invention is to provide a novel compound having EGFR inhibitory effects and cell growth inhibitory effects, as well as a medication useful for the prevention and/or treatment of cancer based on the EGFR inhibitory effects. The present invention provides a compound represented by Formula (I) below, or a salt thereof.