Abstract: To make it possible to observe an observation target from a plurality of different angles and to make, when acquiring and displaying an image including a placement unit separately from an observation image, the image an image with less discomfort. A side-view image capturing unit having an optical axis different from an optical axis of a magnified observation image capturing unit is provided facing a placement table. The side-view image capturing unit is provided so as to eliminate a connection or to lower a connection with a swinging motion of a supporting member to acquire a side-view image. A magnified observation image and the side-view image are displayed.

Abstract: A three-dimensional coordinate measuring device of the present invention achieves high operability and relaxes limitations on the size of a measurement object. A table which places a measurement object thereon is translatable and/or rotatable around a predetermined axis. A position and an attitude of a probe that is capable of designating a measurement position of a measurement object are identified. A displacement resistance mechanism that generates, when an external force is applied to the table in a displacement direction of the table, a certain resistance force against the external force is provided. A table displacement identifying unit that identifies a displacement amount of the table from an original position is provided. Relative position coordinates of a position designated by the probe are obtained on the basis of the position and the attitude of the probe and the displacement amount of the table.

Abstract: To make it possible to observe an observation target from a plurality of different angles and to make, when acquiring and displaying an image including a placement unit separately from an observation image, the image an image with less discomfort. Aside-view image capturing unit having an optical axis different from an optical axis of a magnified observation image capturing unit is provided facing a placement table. The side-view image capturing unit is provided so as to eliminate a connection or to lower a connection with a swinging motion of a supporting member to acquire a side-view image. A magnified observation image and the side-view image are displayed.

Abstract: A three-dimensional coordinate measuring device of the present invention achieves high operability and relaxes limitations on the size of a measurement object. A table which places a measurement object thereon is translatable and/or rotatable around a predetermined axis. A position and an attitude of a probe that is capable of designating a measurement position of a measurement object are identified. A displacement resistance mechanism that generates, when an external force is applied to the table in a displacement direction of the table, a certain resistance force against the external force is provided. A table displacement identifying unit that identifies a displacement amount of the table from an original position is provided. Relative position coordinates of a position designated by the probe are obtained on the basis of the position and the attitude of the probe and the displacement amount of the table.

Abstract: As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.

Abstract: Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.

Abstract: [Problem] A pharmaceutical composition for treating FGFR4-related cancer, FGF 19-related cancer, or FGF19 gene amplification-positive liver cancer is provided. [Means for Solution] The present inventors have investigated a compound having an inhibitory action on FGFR4, and found that a specific pyrimidine compound has an inhibitory action on FGFR4 and a pharmaceutical composition having the compound as an active ingredient has an effect of treating FGFR4-related cancer, in another embodiment, FGF19-related cancer, and in still another embodiment, FGF19 gene amplification-positive liver cancer, thereby completing the present invention.

Abstract: [Problem] An object of the present invention is to elucidate a novel genetic mutation which is a cause of cancer, and thereby, to provide a method for detecting the genetic mutation, or a protein which has the mutation, a method for detecting the presence of cancer in a subject, a method for diagnosing cancer in a subject, and a primer set, a probe and a detecting kit for the methods. [Means for Solution] A method for detecting a fibroblast growth factor receptor 4 (FGFR4) mutant in a subject, which comprises a step of detecting the presence of the mutation of glycine at position 183 in a FGFR4 tyrosine kinase domain to cysteine in a sample obtained from the subject.

Abstract: Disclosed is a vehicle light fitting unit that can include a plurality of light sources, a reflecting plane which diffusely reflects light emitted from the plurality of light sources, and a lens which emits the light, which is diffusely reflected by the reflecting plane, to a front direction. The plurality of light sources can each be provided so that a pitch between one light source and another light source adjacent to the one light source is shorter than a light path length from the one light source to the lens passing through the reflecting plane.

Abstract: [Problem] An object of the present invention is to elucidate a novel genetic mutation which is a cause of cancer, and thereby, to provide a method for detecting the genetic mutation, or a protein which has the mutation, a method for detecting the presence of cancer in a subject, a method for diagnosing cancer in a subject, and a primer set, a probe and a detecting kit for the methods. [Means for Solution] A method for detecting a fibroblast growth factor receptor 4 (FGFR4) mutant in a subject, which comprises a step of detecting the presence of the mutation of glycine at position 183 in a FGFR4 tyrosine kinase domain to cysteine in a sample obtained from the subject.

Abstract: Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.

Abstract: A vehicle light using a projection lens of a novel appearance can provide a feeling of solidness as compared to a simple spherical shape. The vehicle light can include a projection lens having an optical axis and a plurality of separate lens portions divided in a radial pattern with respect to the optical axis of the projection lens. The separate lens portions can have respective light exiting surfaces of different curvatures, and respective light incident surfaces, the shapes of which are determined such that the separate lens portions have the same thickness and the same focal point.

Abstract: A vehicle light can include an LED light source disposed such that the optical axis of the LED light source is directed downward, a first lens disposed forward of the LED light source, a second lens disposed below and forward of the first lens, and a first reflector extending from both sides of the LED light source to a position near the optical axis of the LED light source. The first reflector can be configured to reflect light beams from the LED light source toward the first lens so as to form a wide vertically converged and horizontally diffused light distribution pattern. The vehicle light can include a second reflector disposed at a position below and forward of the first reflector. The second reflector can be configured to reflect light beams from the LED light source toward the second lens so as to form a middle-area vertically converged and horizontally diffused light distribution pattern.

Abstract: A vehicle light unit can convert an LED light source to a linear light emitting state and can be incorporated into a vehicle light. The vehicle light unit can include a first to fourth lens part in front of an LED light source. The first to third lens parts can convert the point light source or the LED light source into a linear light emitting portion with improved light utilization efficiency by providing first to fourth total reflection surfaces utilizing internal reflection to the third lens part. The light rays through the linear light emitting portion can be incident on the fourth lens part. The fourth lens part can include a plate-shaped light guiding portion with a plurality of total reflection surfaces on one surface and corresponding lens cut portions on the other opposite surface.

Abstract: An optical lens for use in a vehicle light can be compact and less expensive and has an outer appearance that has a high commercial value and achieves a high light utilization efficiency. The optical lens can include a light incident surface that receives light from a light source and a light output surface to output the light. The light incident surface can include a center light incident surface formed at its center and being convex toward the light source with a plurality of prisms with a polygonal shape formed radially from its center to its periphery. The light output surface can include a toroidal surface corresponding to the center light incident surface and a surrounding light output surface corresponding to the prisms.

Abstract: It was found that a new fusion gene of a portion of the KIF5B gene and a portion of the RET gene, which is present in a portion of cancer patients, is a gene responsible for cancer. Based on this finding, detection methods of a polynucleotide as the gene and a polypeptide encoded by the polynucleotide were established. The detection methods involve detecting a fusion gene of a portion of the KIF5B gene and a portion of the RET gene, or a fusion protein encoded by such a fusion gene. The primer sets and the detection kits comprise sense primers designed from a portion encoding KIF5B and antisense primers designed from a portion encoding RET.

Abstract: A lighting device with a stable high light intensity can effectively dissipate heat generated by an LED so that the light emission efficiency does not deteriorate while the inside temperature distribution can be maintained in an even state. The lighting device can also be configured to prevent snow from adhering onto an outer lens by allowing an outer surface temperature of the lighting device to rise during actuation of the device. The lighting device can also be configured to improve light utilization efficiency. The lighting device can include a semiconductor light emitting device as a light source and can include structure(s) that guides the emission light to a projection lens. The semiconductor light emitting device can be configured to emit light in a reverse or opposed direction with respect to an illumination direction for the lighting device. A projection lens can be disposed in front of the semiconductor light emitting device.

Abstract: A vehicle light using a projection lens of a novel appearance can provide a feeling of solidness as compared to a simple spherical shape. The vehicle light can include a projection lens having an optical axis and a plurality of separate lens portions divided in a radial pattern with respect to the optical axis of the projection lens. The separate lens portions can have respective light exiting surfaces of different curvatures, and respective light incident surfaces, the shapes of which are determined such that the separate lens portions have the same thickness and the same focal point.

Abstract: Whereas incandescent light bulbs and other similar light sources known in the related art emit light in all directions, LED lamps can emit light in a single direction, and this is manifested in the problem of being unable to achieve light distribution characteristics satisfied by conventional headlamp designs. In accordance with an embodiment of the presently disclosed subject matter, an LED lamp for a light source of a headlamp can include an LED chip in the vicinity of the focus of a projection means and a shielding member covering a portion of the LED chip in a formation allowing a light distribution characteristic suitable for a vehicle front-illumination light to be obtained when light from the LED chip is magnified and projected in an illumination direction by a projection lens or the like constituting the projection means. Accordingly, accurate light distribution characteristics can be obtained in a simple manner by projecting in the illumination direction using the projection lens.

Abstract: Disclosed is a vehicle light fitting unit that can include a plurality of light sources, a reflecting plane which diffusely reflects light emitted from the plurality of light sources, and a lens which emits the light, which is diffusely reflected by the reflecting plane, to a front direction. The plurality of light sources can each be provided so that a pitch between one light source and another light source adjacent to the one light source is shorter than a light path length from the one light source to the lens passing through the reflecting plane.