Abstract: Provided are novel antibody-pyrrolodiazepine derivatives and novel antibody-pyrrolodiazepine derivative conjugates, as well as methods of using the same, and a novel CLDN6 and/or CLDN9 antibody. The disclosed compounds are of the class of alkyl benzene sulfonyl ureas, useful as oral anti-diabetics, and include substituted benzo[e]pyrrolo[1,2-?][1,4]diazepine.

Abstract: In an overtube, an effective length of an outer tube is 1200 mm or longer and 1700 mm or shorter, an effective length of an inner tube is 1400 mm or longer and 2000 mm or shorter, a first maximum protrusion length of an endoscope insertion part from a distal end of the inner tube is 100 mm or longer and 550 mm or shorter, and a second maximum protrusion length of the inner tube from a distal end of the outer tube is 200 mm or longer and 700 mm or shorter. A total maximum protrusion length, which is a sum of the first and second maximum protrusion lengths, is 300 mm or longer and 800 mm or shorter, and a maximum protrusion length ratio, which is a ratio of the first maximum protrusion length to the second maximum protrusion length, is 0.15 or more and 1.0 or less.

Abstract: Provided is an endoscope in which cleaning or disinfection of an elevator housing portion can be reliably performed with a simple configuration. An endoscope includes a distal end part formed with an elevator housing portion, an elevator disposed in the elevator housing portion, and a treatment tool insertion path communicating with a treatment tool outlet that is open to the elevator housing portion, in which the treatment tool insertion path has a diameter-enlarged portion that enlarges in diameter toward the treatment tool outlet.

Abstract: Provided is an endoscope capable of improving cleanability of a distal end portion of an endoscope insertion part. An endoscope includes: a distal end portion including an elevator housing chamber and a lever housing chamber; an elevator housed in the elevator housing chamber; a lever housed in the lever housing chamber; an operation wire connected to the lever; a first partition wall that is provided at the distal end portion and that divides the elevator housing chamber and the lever housing chamber; a rotary shaft that couples the elevator and the lever to each other, the rotary shaft being inserted through a through-hole provided in the first partition wall; and a sealing member that is mounted on the rotary shaft and that seals the through-hole in a case in which the rotary shaft is inserted through the through-hole, the sealing member being attachable and detachable from a lever housing chamber side.

Abstract: Provided is an endoscope capable of improving cleanability of a distal end portion body of an endoscope insertion part. An endoscope includes: a distal end portion body that is provided on a distal end side of an endoscope insertion part; an elevator that is provided on the distal end portion body; a distal end cover that is attachable to and detachable from the distal end portion body; an operation wire that is used to operate the elevator; and a wire insertion passage through which the operation wire is inserted, in which, in a case in which the distal end cover is mounted on the distal end portion body, the distal end cover seals a space portion including at least an outlet of the wire insertion passage.

Abstract: A diamond coated tool includes a base material and a diamond layer provided on the base material. The diamond layer has a boron content of 1×103 ppma or more and 1×106 ppma or less and an oxygen content of 1×102 ppma or more and 1×105 ppma or less in a first region surrounded by a surface of the diamond layer and a first imaginary plane located at a distance of 1 ?m from the surface in a thickness direction.

Abstract: Provided is an endoscope including a cap that can suppress deformation due to a load and that is easily removable. The endoscope incudes a distal-end-portion body and a cap that is removably attached to the distal-end-portion body and that has an open window. The cap includes a cantilever piece that is formed on a wall portion on at least one of sides facing each other with the open window therebetween and that elastically bends, the cantilever piece having a fixed end and a free end and the cantilever piece including a stopper-target portion that is provided at the free end. The distal-end-portion body includes a stopper portion on a side facing the cantilever piece, the stopper portion engaging with the stopper-target portion. The stopper-target portion is removable from the stopper portion.

Abstract: Provided are novel antibody-pyrrolodiazepine derivative and novel antibody-pyrrolodiazepine derivative conjugates, as well as methods of using the same, and a novel CLDN6 and/or CLDN9 antibody. The disclosed compounds are of the class of alkyl benzene sulfonyl ureas, useful as oral anti-diabetics, and include substituted benzo[e]pyrrolo[1,2-?][1,4]diazepine.

Abstract: A biomedical electrode according to the present invention includes: a plate-shaped support portion; an elastic pillar portion that is provided on a first surface of the plate-shaped support portion; and a conductive resin layer that is formed to cover a distal end of the elastic pillar portion, in which when measured at 37° C. according to JIS K 6253 (1997), a type A durometer hardness of a surface of the elastic pillar portion is higher than 35 and 65 or lower.

Abstract: An imaging device capable of image processing is provided. The imaging device can retain analog data (image data) obtained by an image-capturing operation in a pixel and perform a product-sum operation of the analog data and a predetermined weight coefficient in the pixel to convert the data into binary data. When the binary data is taken in a neural network or the like, processing such as image recognition can be performed. Since enormous volumes of image data can be retained in pixels in the state of analog data, processing can be performed efficiently.

Abstract: A washing adapter to be inserted into a space portion of a cylinder, includes a valve member attached to a shaft part, and the valve member is switchable between a contact state of being in contact with an interior wall of the cylinder and a spaced state of being spaced apart from the interior wall. A clogging determination unit switches the valve member between the contact state and the spaced state. The valve member brings at least one pipe line of an air feeding pipe line, an air supply pipe line, a water feeding pipe line, or a water supply pipe line into a state of being out of communication with the other pipe lines in the space portion in the contact state, and brings all of the pipe lines into a state of being in communication with the other pipe lines in the space portion in the spaced state.

Abstract: Provided are a state determination method for an endoscope pipe line, a state determination device for an endoscope pipe line, and an endoscope washing and disinfection device with which it is possible to determine whether an endoscope pipe line is in an open or blocked state with high accuracy. A state determination method for an endoscope pipe line includes a supply step of supplying a pressurized fluid into an endoscope pipe line, a change rate acquisition step of acquiring a change rate of a physical quantity of the fluid within a determination period after the supply of the fluid is stopped, and a determination step of determining whether the endoscope pipe line is in an open or blocked state based on the change rate acquired in the change rate acquisition step.

Abstract: A cutting tool rotates about a rotation axis, and includes a tip end portion. The tip end portion includes a partially spherical surface that is brought into contact with a workpiece. The surface is provided with a plurality of recesses disposed apart from each other. An opening edge of each of the plurality of recesses constitutes a cutting edge.

Abstract: Provided are a distal end cap detachment jig and an endoscope capable of simply and easily detaching a distal end cap from a distal end portion body.

Abstract: An FRP material has a circular arc part, and a member fixed to the circular arc part. The FRP forming system has a portion-pressing device, a member positioning mechanism, and a transport device configured to form the FRP material as a single body of a circular arc-shaped FRP part. The FRP material may comprise a single layer prepreg or a plurality of prepregs that have been layered. The portion-pressing device has upper and lower molds sandwiching a portion of the FRP material in a radial direction orthogonal to the circular arc part, and compresses intermittently a portion of the FRP part. The member positioning mechanism locates the position of the member relatively to the upper or lower mold. The transport device moves the portion of the FRP material that is compressed by the portion-pressing device. The portion-pressing and the transport are repeated to form the FRP part.

Abstract: Provided are an endoscope and a mounting component which are capable of safely detaching a distal end cap from a distal-end-portion body.

Abstract: An aspect of the present disclosure is to accurately estimate whether or not a plurality of people are in close contact with each other in a target space. An estimation system (1) includes a first estimator (12) and a second estimator (13). The first estimator (12) is configured to estimate, based on a heat distribution including a plurality of heat sources detected by at least one infrared sensor (2), three-dimensional positions of heads of a plurality of people in a target space. The second estimator (13) is configured to estimate, based on data on the three-dimensional positions estimated by the first estimator (12), estimate whether or not the plurality of people are in close contact with each other.

Abstract: An FRP continuous molding apparatus continuously molds an FRP from a layered sheet that includes prepreg sheets layered over each other. The prepreg sheets each include thermoplastic resin and reinforcement fibers, and differ from each other in fiber orientation. The FRP continuous molding apparatus includes: sheet feeding devices continuously feeding the layered sheets in a feeding direction; a layering device layering, over each other, the layered sheets fed from the sheet feeding devices, and thereby forming a sheet layered body; and a shaping mechanism molding the sheet layered body into an FRP while the sheet layered body is being transferred in the feeding direction. The FRP has a cross section that is a target shape. The sheet layered body includes the reinforcement fibers whose fiber orientation is the feeding direction.

Abstract: An endoscope includes: a rotation operating part that is rotatably provided on an endoscope operation unit and that moves a bending operation wire forward and backward by being rotationally operated; an engaging part that frictionally engages with the rotation operating part; and a pressing part that is movable between a braking position coming into contact with the engaging part and a non-braking position positioned on a distal side with respect to the engaging part from the braking position. The rotation operating part and the engaging part are integrally rotatable in a case where the pressing part is positioned at the non-braking position, and the rotation operating part and the engaging part are relatively rotatable in a case where the pressing part is positioned at the braking position.

Abstract: A sintered material includes a first material and a second material, wherein the first material is partially stabilized ZrO2 in which 1 to 90 volume % of Al2O3 is dispersed in crystal grain boundaries or crystal grains, the Al2O3 is a grain having a grain size of less than or equal to 1 ?m, and the second material is at least one compound selected from a group consisting of a carbide, a nitride, and a carbonitride, and 5 to 95 volume % of the second material is included in the sintered material.