Patents by Inventor Takashi Hayama
Takashi Hayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7354946Abstract: The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.Type: GrantFiled: December 3, 2004Date of Patent: April 8, 2008Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Takashi Hayama, Kyoko Hayashi, Teruki Honma, Ikuko Takahashi
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Publication number: 20070027147Abstract: The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.Type: ApplicationFiled: December 3, 2004Publication date: February 1, 2007Inventors: Takashi Hayama, Kyoko Hayashi, Teruki Honma, Ikuko Takahashi
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Patent number: 7148224Abstract: The present invention relates to a compound of the general formula (I): [Ar1 is aryl fused to the adjacent pyrazinone ring at the 5th and 6th positions, etc., X is CO, etc., Y is CH, etc., Z is CH, etc., V is CH, etc., Wn is —(CH2)n— (n is zero to four), R1, is H or optionally substituted lower alkyl, etc., R2 is H, etc., R3 and R4 are the same or different and are each H, etc., R5 and R6 are the same or different and are each H, hydroxy, etc.] or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition, an inhibitor of Cdk4 and/or Cdk6 or an anti-cancer agent, containing the same as an active ingredient; and a process for preparing them.Type: GrantFiled: April 14, 2005Date of Patent: December 12, 2006Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Takashi Hayama, Nobuhiko Kawanishi, Tooru Takaki
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Patent number: 6958333Abstract: The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: ? wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.Type: GrantFiled: July 26, 2000Date of Patent: October 25, 2005Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Takashi Hayama, Kyoko Hayashi, Teruki Honma, Ikuko Takahashi
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Publication number: 20050176719Abstract: The present invention relates to a compound of the general formula (I): [Ar1 is aryl fused to the adjacent pyrazinone ring at the 5th and 6th positions, etc., X is CO, etc., Y is CH, etc., Z is CH, etc., V is CH, etc., Wn is —(CH2)n— (n is zero to four), R1, is H or optionally substituted lower alkyl, etc., R2 is H, etc., R3 and R4 are the same or different and are each H, etc., R5 and R6 are the same or different and are each H, hydroxy, etc.] or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition, an inhibitor of Cdk4 and/or Cdk6 or an anti-cancer agent, containing the same as an active ingredient; and a process for preparing them.Type: ApplicationFiled: April 14, 2005Publication date: August 11, 2005Inventors: Takashi Hayama, Nobuhiko Kawanishi, Tooru Takaki
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Patent number: 6914062Abstract: The present invention relates to a compound of the general formula (I): [Ar1 is aryl fused to the adjacent pyrazinone ring at the 5th and 6th positions, etc., X is CO, etc., Y is CH, etc., Z is CH, etc., V is CH, etc., Wn is —(CH2)n— (n is zero to four), R1 is H or optionally substituted lower alkyl, etc., R2 is H, etc., R3 and R4 are the same or different and are each H, etc., R5 and R6 are the same or different and are each H, hydroxy, etc.] or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition, an inhibitor of Cdk4 and/or Cdk6 or an anti-cancer agent, containing the same as an active ingredient; and a process for preparing them.Type: GrantFiled: June 28, 2001Date of Patent: July 5, 2005Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Takashi Hayama, Nobuhiko Kawanishi, Tooru Takaki
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Publication number: 20030203907Abstract: The present invention relates to a compound of the general formula (I): 1Type: ApplicationFiled: January 31, 2003Publication date: October 30, 2003Inventors: Takashi Hayama, Nobuhiko Kawanishi, Tooru Takaki
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Patent number: 6413979Abstract: The present invention relates to a cyclopentenopyridine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, wherein Ar is a phenyl group or the like. R1 is a mono- or di-C1-C6 alkylamino group or the like, and R2 is a hydroxyl group or the like, a process for its production and its use.Type: GrantFiled: July 21, 2000Date of Patent: July 2, 2002Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Takashi Hayama, Norikazu Otake, Masaru Nishikibe
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Patent number: 6310276Abstract: A plant which belongs to the genus Limonium, having a characteristic of undergoing flower bud differentiation and flower stalk development within 50 days from seeding even without low temperatures of 25° C. or below; and a method for creating the plant are disclosed.Type: GrantFiled: August 31, 1998Date of Patent: October 30, 2001Assignee: Sakata Seed CorporationInventors: Masahiro Nakagawa, Takashi Hayama
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Patent number: 5714479Abstract: A heteroaromatic ring-fused cyclopentene derivative of the formula: ##STR1## wherein the variables are as defined in the specification; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: February 20, 1996Date of Patent: February 3, 1998Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Toshio Nagase, Toshiaki Mase, Takashi Hayama, Masaki Ihara, Masaru Nishikibe, Mitsuo Yano
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Patent number: 5691315Abstract: The invention relates to compounds which are antagonists of endothelin, to processes for their preparation, and to their use as pharmaceuticals. The compounds of the invention are Useful in the treatment of hypertension, pulmonary hypertension, Reynaud's disease, myocardial infarction, angina pectoris, acute renal failure, cerebral infarction, cerebral vasospasm, arteriosclerosis, asthma, endotoxin shock, endotoxin-induced multiple organ failure or disseminated intravascular coagulation, and/or cyclosporin-induced renal failure or hypertension.Type: GrantFiled: June 26, 1995Date of Patent: November 25, 1997Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano
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Patent number: 5529977Abstract: Disclosed are a pyrimidine or triazine compound represented by the following formula (I): ##STR1## wherein R.sup.1 represents cyano group, a halogen atom, hydroxy group or --O--R.sup.7 where R.sup.7 represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a halo-lower alkyl group or a cyano-lower alkyl group; R.sup.2 represents hydrogen atom or a lower alkyl group; R.sup.3 represents hydrogen atom or a lower alkyl group; R.sup.4 represents a 1-imidazolyl group, --NHSO.sub.2 --R.sup.8 where R.sup.8 represents a lower alkyl group or a phenyl group which may have a substituent, hydroxy group, a lower alkoxy group or a benzyloxy group when Z is nitrogen atom; or a 1-imidazolyl group, --NHSO.sub.2 --R.sup.8 where R.sup.Type: GrantFiled: October 21, 1994Date of Patent: June 25, 1996Assignee: UBE Industries, Ltd.Inventors: Katsumasa Harada, Takaaki Abe, Yuji Akiyoshi, Akio Matsushita, Mikio Kojima, Ikuo Shiraishi, Kaoru Yamamoto, Takashi Hayama
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Patent number: 5498717Abstract: This invention relates to novel 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols, a process for preparing the 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols reioselectively and in a high yield utilizing the Bischler-Napieralski reaction, a process for synthesizing 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ols via the compounds, and use of the 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols for preparation of the 6,7-dialkoxy-1, 2,3,4-tetrahydroisoquinolin-8-ols.It is possible according to this invention, to obtain the 6,7 -dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ols, which have hitherto been difficult to synthesize, via the 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols in a high yield.Type: GrantFiled: August 10, 1994Date of Patent: March 12, 1996Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takashi Hayama
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Patent number: 5496928Abstract: Peptides having the formula: ##STR1## inhibit the binding of endothelin and are useful in treating diseases associated with excess production or secretion of endothelin.Type: GrantFiled: April 20, 1994Date of Patent: March 5, 1996Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano, Masaru Nishikibe
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Patent number: 5470833Abstract: Peptides having the formula: ##STR1## inhibit the binding of endothelin to its receptor and are useful in treating diseases associated with excess production or secretion of endothelin.Type: GrantFiled: March 14, 1994Date of Patent: November 28, 1995Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano
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Patent number: 5446164Abstract: This invention relates to novel 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols, a process for preparing the 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols reioselectively and in a high yield utilizing the Bischler-Napieralski reaction, a process for synthesizing 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ols via the compounds, and use of the 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols for preparation of the 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ols.It is possible, according to this invention, to obtain the 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ols, which have hitherto been difficult to synthesize, via the 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols in a high yield.Type: GrantFiled: February 22, 1994Date of Patent: August 29, 1995Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takashi Hayama
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Patent number: 5444152Abstract: Peptides having the formula ##STR1## inhibit the binding of endothelin to its receptor and are useful in treating diseases associated with excess production or secretion of endothelin.Type: GrantFiled: March 21, 1994Date of Patent: August 22, 1995Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano
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Patent number: 5389620Abstract: A heteroaromatic ring-fused cyclopentene derivative of the formula: ##STR1## wherein the variables are as defined in the specification; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 14, 1993Date of Patent: February 14, 1995Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Toshio Nagase, Toshiaki Mase, Takashi Hayama, Masaki Ihara, Masaru Nishikibe, Mitsuo Yano
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Patent number: 5389601Abstract: Disclosed are a 3-alkoxy-N-cyclolalkylsulfonylalkanoic amide compound represented by the formula (I): ##STR1## wherein R represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a halo-lower alkyl group or a cyano-lower alkyl group; X represents an oxygen atom or a sulfur atom; Z represents a --CH.dbd. group or a nitrogen atom; and n represents an integer of 2 to 9,a process for preparing the same and a herbicide containing the same as an active ingredient(s).Type: GrantFiled: July 20, 1993Date of Patent: February 14, 1995Assignee: Ube Industries, Ltd.Inventors: Takaaki Abe, Yuji Akiyoshi, Hiroshi Shiraishi, Ikuo Shiraishi, Takashi Hayama
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Patent number: 5387575Abstract: Disclosed are a pyrimidine or triazine compound represented by the following formula (I): ##STR1## wherein R.sup.1 represents cyano group, a halogen atom, hydroxy group or --O--R.sup.7 where R.sup.7 represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a halo-lower alkyl group or a cyano-lower alkyl group; R.sup.2 represents hydrogen atom or a lower alkyl group; R.sup.3 represents hydrogen atom or a lower alkyl group; R.sup.4 represents a 1-imidazolyl group, --NHSO.sub.2 --R.sup.8 where R.sup.8 represents a lower alkyl group or a phenyl group which may have a substituent, hydroxy group, a lower alkoxy group or a benzyloxy group when Z is nitrogen atom; or a 1-imidazolyl group, --NHSO.sub.2 --R.sup.8 where R.sup.Type: GrantFiled: June 5, 1992Date of Patent: February 7, 1995Assignee: Ube Industries, Ltd.Inventors: Katsumasa Harada, Takaaki Abe, Yuji Akiyoshi, Akio Matsushita, Mikio Kojima, Ikuo Shiraishi, Kaoru Yamamoto, Takashi Hayama, Shohei Fukuda