Patents by Inventor Takashi Inaba

Takashi Inaba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250084106
    Abstract: The present invention provides processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives, which are useful as a Janus kinase (JAK) inhibitor, intermediates thereof, and processes for preparing the intermediates. The present invention provides processes for preparing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile using salts of (3S,4R)-1-benzyl-3-methyl-1,6-diazaspiro[3.4]octane with organic acids.
    Type: Application
    Filed: November 26, 2024
    Publication date: March 13, 2025
    Inventors: Hiromu Takiguchi, Akinobu Higashi, Takashi Inaba, Takashi Watanabe, Tsubasa Takeichi, Anders Klarskov Petersen, Per Vedsoe, Kim Lebek Jensen, Jan Bornholdt, Soren Ebdrup
  • Patent number: 12195481
    Abstract: The present invention provides processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives, which are useful as a Janus kinase (JAK) inhibitor, intermediates thereof, and processes for preparing the intermediates. The present invention provides processes for preparing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile using salts of (3S,4R)-1-benzyl-3-methyl-1,6-diazaspiro[3.4]octane with organic acids.
    Type: Grant
    Filed: April 19, 2023
    Date of Patent: January 14, 2025
    Assignees: Japan Tobacco Inc., Leo Pharma A/S
    Inventors: Hiromu Takiguchi, Akinobu Higashi, Takashi Inaba, Takashi Watanabe, Tsubasa Takeichi, Anders Klarskov Petersen, Per Vedsoe, Kim Lebek Jensen, Jan Bornholdt, Soren Ebdrup
  • Publication number: 20240140967
    Abstract: The present invention provides processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives, which are useful as a Janus kinase (JAK) inhibitor, intermediates thereof, and processes for preparing the intermediates. The present invention provides processes for preparing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile using salts of (3S,4R)-1-benzyl-3-methyl-1,6-diazaspiro[3.4]octane with organic acids.
    Type: Application
    Filed: April 19, 2023
    Publication date: May 2, 2024
    Inventors: Hiromu Takiguchi, Akinobu Higashi, Takashi Inaba, Takashi Watanabe, Tsubasa Takeichi, Anders Klarskov Petersen, Per Vedsoe, Kim Lebek Jensen, Jan Bornholdt, Soren Ebdrup
  • Patent number: 11673900
    Abstract: The present invention provides processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives, which are useful as a Janus kinase (JAK) inhibitor, intermediates thereof, and processes for preparing the intermediates. The present invention provides processes for preparing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile using salts of (3S,4R)-1-benzyl-3-methyl-1,6-diazaspiro[3.4]octane with organic acids.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 13, 2023
    Assignees: Japan Tobacco Inc., LEO Pharma A/S
    Inventors: Hiromu Takiguchi, Akinobu Higashi, Takashi Inaba, Takashi Watanabe, Tsubasa Takeichi, Anders Klarskov Petersen, Per Vedsoe, Kim Lebek Jensen, Jan Bornholdt, Soren Ebdrup
  • Patent number: 10981877
    Abstract: A production method of a compound represented by the formula [I]: or a pharmaceutically acceptable salt thereof, or a hydrate thereof.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: April 20, 2021
    Assignee: JAPAN TOBACCO INC.
    Inventors: Takahisa Motomura, Masafumi Inoue, Hirotsugu Ito, Takuya Matsuo, Koichi Suzawa, Hiroshi Yamamoto, Tsubasa Takeichi, Yasuyuki Kajimoto, Takashi Inaba, Takao Ito, Takahiro Yamasaki, Yukishige Ikemoto
  • Publication number: 20200216470
    Abstract: The present invention provides processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives, which are useful as a Janus kinase (JAK) inhibitor, intermediates thereof, and processes for preparing the intermediates. The present invention provides processes for preparing 3-[(3S, 4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile using salts of (3S,4R)-1-benzyl-3-methyl-1,6-diazaspiro[3.4]octane with organic acids.
    Type: Application
    Filed: December 20, 2017
    Publication date: July 9, 2020
    Inventors: Hiromu Takiguchi, Akinobu Higashi, Takashi Inaba, Takashi Watanabe, Tsubasa Takeichi, Anders Klarskov Petersen, Per Vedsoe, Kim Lebek Jensen, Jan Bornholdt, Soren Ebdrup
  • Publication number: 20190375717
    Abstract: A production method of a compound represented by the formula [I]: or a pharmaceutically acceptable salt thereof, or a hydrate thereof.
    Type: Application
    Filed: July 28, 2017
    Publication date: December 12, 2019
    Inventors: Takahisa Motomura, Masafumi Inoue, Hirotsugu Ito, Takuya Matsuo, Koichi Suzawa, Hiroshi Yamamoto, Tsubasa Takeichi, Yasuyuki Kajimoto, Takashi Inaba, Takao Ito, Takahiro Yamasaki, Yukishige Ikemoto
  • Patent number: 8420011
    Abstract: The present invention provides an Al—Mg series alloy sheet of high-Mg with improved press formability and homogeneity which can be applied to automobile outer panels and inner panels. This is an Al—Mg series aluminum alloy sheet having 0.5 to 3 mm in thickness cast by twin-roll continuous casting and cold rolled, comprising over 8% but not more than 14% Mg, 1.0% or less Fe, and 0.5% or less Si with the remainder being Al and unavoidable impurities wherein the mean conductivity of the aluminum alloy sheet is in the range of at least 20 IACS % but less than 26 IACS %, the strength-ductility balance (tensile strength×total elongation) as a material property of the aluminum alloy sheet is 11000 (MPa %) or more, and the homogeneity and press formability of the sheet have been improved.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: April 16, 2013
    Assignee: Kobe Steel, Ltd.
    Inventors: Makoto Morishita, Katsushi Matsumoto, Shigenobu Yasunaga, Takashi Inaba
  • Patent number: 8381797
    Abstract: Skin material of a clad material is composed of one or more layers, each layer of the skin materials is made of a metal different from the core material in their component compositions, and at least one layer of the skin material has a cast microstructure, when the skin material is superposed on either of one or both faces of the core material.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: February 26, 2013
    Assignee: Kobe Steel, Ltd.
    Inventors: Masayuki Takada, Yasuhiro Nishioka, Tomohiro Nishimura, Kenji Tokuda, Toshiki Ueda, Makoto Morishita, Takashi Inaba, Akihiro Tsuruno, Yoshinori Kato, Fumihiro Koshigoe, Masaki Tanigawa, Naoki Sakashita, Kenji Harada, Jitsuto Shikata, Masanori Ikeda
  • Patent number: 8210237
    Abstract: Equipment for manufacturing skin material of a clad material includes a casting apparatus which melts and mixes a metal for the skin material different from the core material in their component compositions, and casts the skin material; an ingot-cutting apparatus which cuts an ingot for skin material which is cast by the casting apparatus; and a conveying apparatus which conveys the ingot for skin material among each apparatus. The ingot-cutting apparatus is a slicing apparatus which slices the ingot for skin material into a predetermined thickness.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: July 3, 2012
    Assignee: Kobe Steel, Ltd.
    Inventors: Masayuki Takada, Yasuhiro Nishioka, Tomohiro Nishimura, Kenji Tokuda, Toshiki Ueda, Makoto Morishita, Takashi Inaba, Akihiro Tsuruno, Yoshinori Kato, Fumihiro Koshigoe, Masaki Tanigawa, Naoki Sakashita, Kenji Harada, Jitsuto Shikata, Masanori Ikeda
  • Patent number: 8191609
    Abstract: A method for manufacturing a clad material composed of a core material and one or more skin materials which are superposed on either one or both faces of the core material, includes a clad material preparation process where an ingot for core material is manufactured by dissolving and casting a metal, and an ingot for skin material is manufactured by dissolving and casting a different metal for skin material, without hot rolling. The ingot for skin material is superposed as a skin material at a predetermined position of either one or both faces of the ingot for core material and the superposed material is hot-rolled to manufacture a clad material.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: June 5, 2012
    Assignee: Kobe Steel, Ltd.
    Inventors: Masayuki Takada, Yasuhiro Nishioka, Tomohiro Nishimura, Kenji Tokuda, Toshiki Ueda, Makoto Morishita, Takashi Inaba, Akihiro Tsuruno, Yoshinori Kato, Fumihiro Koshigoe, Masaki Tanigawa, Naoki Sakashita, Kenji Harada, Jitsuto Shikata, Masanori Ikeda
  • Publication number: 20120018497
    Abstract: A method for manufacturing a clad material composed of a core material and one or more skin materials which are superposed on either one or both faces of the core material, includes a clad material preparation process where an ingot for core material is manufactured by dissolving and casting a metal, and an ingot for skin material is manufactured by dissolving and casting a different metal for skin material, without hot rolling. The ingot for skin material is superposed as a skin material at a predetermined position of either one or both faces of the ingot for core material and the superposed material is hot-rolled to manufacture a clad material.
    Type: Application
    Filed: September 22, 2011
    Publication date: January 26, 2012
    Applicant: Kabushiki Kaisha Kobe Seiko Sho (Kobe Steel, Ltd.)
    Inventors: Masayuki Takada, Yasuhiro Nishioka, Tomohiro Nishimura, Kenji Tokuda, Toshiki Ueda, Makoto Morishita, Takashi Inaba, Akihiro Tsuruno, Yoshinori Kato, Fumihiro Koshigoe, Masaki Tanigawa, Naoki Sakashita, Kenji Harada, Jitsuto Shikata, Masanori Ikeda
  • Patent number: 8091612
    Abstract: A method for manufacturing a clad material composed of a core material and one or more skin materials which are superposed on either one or both faces of the core material, includes a clad material preparation process where an ingot for core material is manufactured by melting and casting a metal, and an ingot for skin material is manufactured by melting and casting a different metal for skin material, without hot rolling. The ingot for skin material is superposed as a skin material at a predetermined position of either one or both faces of the ingot for core material and the superposed material is hot-rolled to manufacture a clad material.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: January 10, 2012
    Assignee: Kobe Steel, Ltd.
    Inventors: Masayuki Takada, Yasuhiro Nishioka, Tomohiro Nishimura, Kenji Tokuda, Toshiki Ueda, Makoto Morishita, Takashi Inaba, Akihiro Tsuruno, Yoshinori Kato, Fumihiro Koshigoe, Masaki Tanigawa, Naoki Sakashita, Kenji Harada, Jitsuto Shikata, Masanori Ikeda
  • Publication number: 20110253338
    Abstract: Equipment for manufacturing skin material of a clad material includes a casting apparatus which melts and mixes a metal for the skin material different from the core material in their component compositions, and casts the skin material; an ingot-cutting apparatus which cuts an ingot for skin material which is cast by the casting apparatus; and a conveying apparatus which conveys the ingot for skin material among each apparatus. The ingot-cutting apparatus is a slicing apparatus which slices the ingot for skin material into a predetermined thickness.
    Type: Application
    Filed: June 15, 2011
    Publication date: October 20, 2011
    Applicant: Kabushiki Kaisha Kobe Seiko Sho (Kobe Steel, Ltd.)
    Inventors: Masayuki TAKADA, Yasuhiro NISHIOKA, Tomohiro NISHIMURA, Kenji TOKUDA, Toshiki UEDA, Makoto MORISHITA, Takashi INABA, Akihiro TSURUNO, Yoshinori KATO, Fumihiro KOSHIGOE, Masaki TANIGAWA, Naoki SAKASHITA, Kenji HARADA, Jitsuto SHIKATA, Masanori IKEDA
  • Publication number: 20110240247
    Abstract: Skin material of a clad material is composed of one or more layers, each layer of the skin materials is made of a metal different from the core material in their component compositions, and at least one layer of the skin material has a cast microstructure, when the skin material is superposed on either of one or both faces of the core material.
    Type: Application
    Filed: June 15, 2011
    Publication date: October 6, 2011
    Applicant: Kabushiki Kaisha Kobe Seiko Sho (Kobe Steel, Ltd.)
    Inventors: Masayuki Takada, Yasuhiro Nishioka, Tomohiro Nishimura, Kenji Tokuda, Toshiki Ueda, Makoto Morishita, Takashi Inaba, Akihiro Tsuruno, Yoshinori Kato, Fumihiro Koshigoe, Masaki Tanigawa, Naoki Sakashita, Kenji Harada, Jitsuto Shikata, Masanori Ikeda
  • Publication number: 20100105894
    Abstract: The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30, etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.
    Type: Application
    Filed: June 9, 2009
    Publication date: April 29, 2010
    Inventors: Takashi Inaba, Julia Haas, Makoto Shiozaki, Nicole M. Littmann, Katsutaka Yasue, Steven W. Andrews, Atushi Sakai, Andrew M. Fryer, Takafuml Matsuo, Ellen R. Laird, Akira Suma, Yuichi Shinozaki, Yoshikazu Hori, Hiroto Imai, Tamotsu Negoro
  • Patent number: 7704451
    Abstract: An aluminum alloy sheet contains 0.1% to 0.4% by mass of Cu, 0.5% to 1.5% by mass of Mg, 0.5% to 1.5% by mass of Mn, 0.2% to 0.7% by mass of Fe, and 0.1% to 0.3% by mass of Si. The number density of Al—Mn—Fe—Si-based intermetallic compound having a maximum length of 8 to 15 ?m per unit area is 179 grains/mm2 or less. An oxide film having an average thickness of 30 nm or less is formed on the surface of the aluminum alloy sheet. The arithmetic average roughness Ra of the surface of the aluminum alloy sheet is 0.30 to 0.45 ?m.
    Type: Grant
    Filed: April 20, 2005
    Date of Patent: April 27, 2010
    Assignee: Kobe Steel, Ltd.
    Inventors: Kenji Kuroda, Etsuko Kuroda, legal representative, Takashi Inaba
  • Publication number: 20090130481
    Abstract: The present invention provides a method for manufacturing a clad material and the equipment for manufacturing the clad material, in which the productivity is excellent, the surface state and the flatness of the clad material can be readily controlled and the deterioration in adhesion rarely occurs in the clad material.
    Type: Application
    Filed: December 7, 2006
    Publication date: May 21, 2009
    Inventors: Masayuki Takada, Yasuhiro Nishioka, Tomohiro Nishimura, Kenji Tokuda, Toshiki Ueda, Makoto Morishita, Takashi Inaba, Akihiro Tsuruno, Yoshinori Kato, Fumihiro Koshigoe, Masaki Tanigawa, Naoki Sakashita, Kenji Harada, Jitsuto Shikata, Masanori Ikeda
  • Publication number: 20090071576
    Abstract: The present invention provides an Al—Mg series alloy sheet of high-Mg with improved press formability and homogeneity which can be applied to automobile outer panels and inner panels. This is an Al—Mg series aluminum alloy sheet having 3.5 to 3 mm in thickness cast by twin-roll continuous casting and cold rolled, comprising over 8% but not more than 14% Mg, 1.0% or less Fe, and 3.5% or less Si with the remainder being Al and unavoidable impurities wherein the mean conductivity of the aluminum alloy sheet is in the range of at least 20 IACS % but less than 26 IACS %, the strength-ductility balance (tensile strength×total elongation) as a material property of the aluminum alloy sheet is 11000 (MPa %) or more, and the homogeneity and press formability of the sheet have been improved.
    Type: Application
    Filed: January 13, 2006
    Publication date: March 19, 2009
    Applicant: KABUSHIKI KAISHA KOBE SEIKO SHO
    Inventors: Makoto Morishita, Katsushi Matsumoto, Shigenobu Yasunaga, Takashi Inaba
  • Publication number: 20080306258
    Abstract: The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30 etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.
    Type: Application
    Filed: May 6, 2008
    Publication date: December 11, 2008
    Inventors: Takashi Inaba, Julia Haas, Makoto Shiozaki, Nicole M. Littmann, Katsutaka Yasue, Steven W. Andrews, Atushi Sakai, Andrew M. Fryer, Takafumi Matsuo, Ellen R. Laird, Akira Suma, Yuichi Shinozaki, Yoshikazu Hori, Hiroto Imai, Tamotsu Negoro